Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1122218..1123023 Replicon chromosome
Accession NZ_CP017460
Organism Staphylococcus nepalensis strain JS1

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag BJD96_RS05315 Protein ID WP_096808992.1
Coordinates 1122841..1123023 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag BJD96_RS05310 Protein ID WP_096808990.1
Coordinates 1122218..1122817 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJD96_RS05290 1118090..1119553 + 1464 WP_096808982.1 ABC transporter substrate-binding protein/permease -
BJD96_RS05295 1119546..1120268 + 723 WP_096808984.1 amino acid ABC transporter ATP-binding protein -
BJD96_RS05300 1120433..1121560 + 1128 WP_096808986.1 tRNA epoxyqueuosine(34) reductase QueG -
BJD96_RS05305 1121565..1122035 + 471 WP_096808988.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
BJD96_RS05310 1122218..1122817 + 600 WP_096808990.1 glucosamine-6-phosphate isomerase Antitoxin
BJD96_RS05315 1122841..1123023 + 183 WP_096808992.1 hypothetical protein Toxin
BJD96_RS05320 1123227..1123640 + 414 WP_096808994.1 hypothetical protein -
BJD96_RS05325 1123851..1125236 + 1386 WP_096808996.1 class II fumarate hydratase -
BJD96_RS05330 1125496..1126323 - 828 WP_096808998.1 RluA family pseudouridine synthase -
BJD96_RS05335 1126521..1127630 + 1110 WP_096809000.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-195)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6910.28 Da        Isoelectric Point: 3.8145

>T66834 WP_096808992.1 NZ_CP017460:1122841-1123023 [Staphylococcus nepalensis]
MRNDSTKNQLNHDTEVENEMVDGFEDVVELGKEMEQISEENDEDKLDKAHDASVRSDLDD

Download         Length: 183 bp

>T66834 NZ_CP017460:1122841-1123023 [Staphylococcus nepalensis]
ATGAGAAATGATAGTACTAAAAACCAATTAAATCATGATACTGAAGTAGAAAATGAAATGGTTGATGGTTTTGAAGATGT
TGTAGAGTTAGGTAAAGAAATGGAACAAATTTCTGAAGAAAACGACGAAGATAAGCTAGATAAAGCACATGATGCAAGCG
TGCGTTCAGATTTAGATGATTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22323.12 Da        Isoelectric Point: 4.9602

>AT66834 WP_096808990.1 NZ_CP017460:1122218-1122817 [Staphylococcus nepalensis]
MAMNFKVLENERIVAEYAADILRKQFNNNPTTIAGVHLSNDNAPVLDELKKNIDNNAVDFSQINILDYDSNKSYFEALGV
PEGQIYGISYGEDTESFISDKIKTKENKGKLITQILSIDTNSRLNVSINHGLFSAREVILVITGSEKKNIVHKLYEENGK
TSFEPADLKAHRMVNVILDEAAAEGLPEDVRHYFTARFA

Download         Length: 600 bp

>AT66834 NZ_CP017460:1122218-1122817 [Staphylococcus nepalensis]
ATGGCAATGAACTTTAAAGTTTTAGAAAATGAAAGAATCGTAGCAGAATATGCTGCTGATATTTTAAGAAAACAATTTAA
CAATAATCCAACAACTATTGCTGGTGTGCACCTTTCTAATGATAATGCACCAGTATTAGATGAACTAAAGAAAAATATAG
ATAATAATGCTGTAGATTTTAGTCAAATTAATATATTAGACTATGACAGTAATAAGTCATATTTTGAAGCATTAGGTGTA
CCAGAAGGCCAAATTTACGGTATTTCTTATGGCGAAGACACAGAATCATTTATAAGTGACAAGATTAAAACTAAAGAAAA
TAAAGGTAAATTGATTACGCAAATACTTTCTATTGATACAAATAGTCGACTTAATGTAAGTATTAATCATGGTCTGTTTT
CTGCAAGAGAAGTTATATTGGTCATTACTGGTAGTGAGAAAAAAAATATTGTTCATAAATTATACGAAGAAAATGGTAAG
ACTTCATTTGAACCCGCTGATTTAAAAGCGCATCGCATGGTTAATGTTATTTTGGATGAAGCAGCTGCAGAAGGTCTGCC
AGAAGATGTTCGTCACTATTTCACTGCACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References