Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 963677..964191 Replicon chromosome
Accession NZ_CP017460
Organism Staphylococcus nepalensis strain JS1

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag BJD96_RS04415 Protein ID WP_096808803.1
Coordinates 963985..964191 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag BJD96_RS04410 Protein ID WP_096808802.1
Coordinates 963677..963970 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJD96_RS04390 959347..959985 + 639 WP_096808798.1 thiamine phosphate synthase -
BJD96_RS04395 960073..960942 + 870 WP_096808799.1 membrane protein insertase YidC -
BJD96_RS04400 961078..961731 - 654 WP_096808800.1 HD domain-containing protein -
BJD96_RS04405 962051..963535 - 1485 WP_096808801.1 cardiolipin synthase -
BJD96_RS04410 963677..963970 + 294 WP_096808802.1 copper-sensing transcriptional repressor CsoR Antitoxin
BJD96_RS04415 963985..964191 + 207 WP_096808803.1 heavy-metal-associated domain-containing protein Toxin
BJD96_RS04420 964515..964655 + 141 WP_002482742.1 hypothetical protein -
BJD96_RS04425 964802..965101 - 300 WP_096808804.1 transposase -
BJD96_RS04430 965236..966429 - 1194 WP_096808805.1 rod shape-determining protein RodA -
BJD96_RS04435 966691..967761 + 1071 WP_096808806.1 D-alanine--D-alanine ligase -
BJD96_RS04440 967774..969129 + 1356 WP_096808807.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(20-65)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7919.04 Da        Isoelectric Point: 4.6472

>T66832 WP_096808803.1 NZ_CP017460:963985-964191 [Staphylococcus nepalensis]
MNSQAIYIKNIENEANKIQIESHLAQLIGVYNVSVDKDYKRVLIDFKTPANLNNLEKEIYDLGFEILY

Download         Length: 207 bp

>T66832 NZ_CP017460:963985-964191 [Staphylococcus nepalensis]
ATGAATTCACAAGCGATTTATATAAAAAACATAGAAAATGAAGCAAACAAAATTCAAATTGAAAGTCATTTGGCGCAACT
TATAGGCGTATACAATGTTTCAGTTGATAAAGATTATAAGCGAGTGCTTATTGATTTTAAAACACCTGCAAATTTAAATA
ATTTAGAAAAAGAAATATATGATTTAGGTTTTGAAATTTTATACTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11144.73 Da        Isoelectric Point: 6.8617

>AT66832 WP_096808802.1 NZ_CP017460:963677-963970 [Staphylococcus nepalensis]
MAETQKAHHSEQTKSNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNQGEQ
QEAMDELLVTFQKLMKD

Download         Length: 294 bp

>AT66832 NZ_CP017460:963677-963970 [Staphylococcus nepalensis]
ATGGCAGAAACGCAAAAAGCACACCATTCTGAACAAACTAAATCCAATTTAAAGTCTAGATTAAATCGTATCGAAGGCCA
AGTAAAAGCAATCAACCGCATGATAGATGAAGATGTATACTGTGATGATGTACTCACACAAATTAGAGCGACAAGATCTG
CTTTAAATAGCGTTGCAACAAAACTATTAGATCATCATATGAAGAGTTGTATCATGGACAAGGTCAATCAGGGCGAGCAG
CAAGAGGCTATGGATGAACTGTTAGTTACTTTTCAAAAATTGATGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References