Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 2777024..2777723 Replicon chromosome
Accession NZ_CP017459
Organism Staphylococcus nepalensis strain JS9

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag BJG88_RS13390 Protein ID WP_096811086.1
Coordinates 2777024..2777425 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag BJG88_RS13395 Protein ID WP_096811087.1
Coordinates 2777481..2777723 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJG88_RS13375 2772619..2773167 + 549 WP_096811084.1 YdhK family protein -
BJG88_RS14120 2773283..2773789 - 507 WP_198401685.1 hypothetical protein -
BJG88_RS14125 2774205..2775275 - 1071 WP_198401687.1 hypothetical protein -
BJG88_RS13385 2775816..2776271 + 456 WP_096811085.1 DUF805 domain-containing protein -
BJG88_RS13390 2777024..2777425 - 402 WP_096811086.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
BJG88_RS13395 2777481..2777723 - 243 WP_096811087.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BJG88_RS13400 2778268..2778960 + 693 WP_096811088.1 ATP-binding cassette domain-containing protein -
BJG88_RS13405 2778963..2779736 + 774 WP_096811089.1 ABC transporter permease -
BJG88_RS13410 2780006..2780266 + 261 WP_096811090.1 hypothetical protein -
BJG88_RS13420 2780551..2780790 + 240 WP_096811092.1 DUF3923 family protein -
BJG88_RS13425 2780910..2781518 + 609 WP_096811093.1 stage II sporulation protein M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-87)

Antitoxin

SpoVT-AbrB domain

(10-52)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15412.82 Da        Isoelectric Point: 5.8914

>T66831 WP_096811086.1 NZ_CP017459:c2777425-2777024 [Staphylococcus nepalensis]
MQYLTEKDIITLNVYVINKYSPNEQIGVKEPNALNMLVNAPKQCVFGEEQYPTLELKAANLVRNLVQKHVFYNGNKRTAL
MTLVVFLKMNGYQFNASNEEVADYMVKIATDDLQEADIKQWIKKYITLMNEKD

Download         Length: 402 bp

>T66831 NZ_CP017459:c2777425-2777024 [Staphylococcus nepalensis]
ATGCAGTATTTAACAGAAAAAGACATTATCACACTAAATGTATATGTTATTAATAAATATAGCCCTAATGAGCAAATAGG
CGTAAAAGAACCAAATGCTTTAAATATGCTAGTTAACGCACCTAAGCAATGTGTATTTGGTGAAGAACAGTACCCCACTT
TAGAACTGAAAGCAGCTAACTTAGTTAGAAATTTAGTACAAAAACATGTGTTTTACAATGGTAATAAAAGAACAGCTTTA
ATGACATTGGTTGTTTTCCTTAAGATGAATGGATATCAGTTTAATGCTAGTAATGAAGAAGTGGCCGACTATATGGTTAA
AATTGCTACAGACGACTTACAGGAAGCAGACATTAAGCAATGGATTAAAAAGTATATAACACTAATGAATGAAAAGGATT
GA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8876.08 Da        Isoelectric Point: 4.5045

>AT66831 WP_096811087.1 NZ_CP017459:c2777723-2777481 [Staphylococcus nepalensis]
MAVTNTRKLRKIGNSKVLTIPEEVIQALDINEGQKIAFNVENGQVVLEAVKTDSNEMDILSMADQVSNQYDSALKDLVNR

Download         Length: 243 bp

>AT66831 NZ_CP017459:c2777723-2777481 [Staphylococcus nepalensis]
ATGGCAGTAACTAACACAAGAAAACTTAGAAAAATTGGCAATAGCAAGGTTCTAACAATACCAGAGGAAGTAATACAAGC
TTTAGATATTAATGAGGGACAAAAAATCGCATTTAACGTTGAGAATGGTCAAGTGGTATTAGAAGCAGTTAAAACGGATA
GTAACGAAATGGATATTTTAAGCATGGCCGATCAAGTAAGTAATCAGTATGATAGTGCTTTAAAAGATTTAGTGAATAGA
TAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References