Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tsbAT/-
Location 1144923..1145728 Replicon chromosome
Accession NZ_CP017459
Organism Staphylococcus nepalensis strain JS9

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag BJG88_RS05460 Protein ID WP_096808992.1
Coordinates 1145546..1145728 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag BJG88_RS05455 Protein ID WP_096808990.1
Coordinates 1144923..1145522 (+) Length 200 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJG88_RS05435 1140795..1142258 + 1464 WP_108909268.1 ABC transporter substrate-binding protein/permease -
BJG88_RS05440 1142251..1142973 + 723 WP_096808984.1 amino acid ABC transporter ATP-binding protein -
BJG88_RS05445 1143138..1144265 + 1128 WP_096808986.1 tRNA epoxyqueuosine(34) reductase QueG -
BJG88_RS05450 1144270..1144740 + 471 WP_096808988.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
BJG88_RS05455 1144923..1145522 + 600 WP_096808990.1 glucosamine-6-phosphate isomerase Antitoxin
BJG88_RS05460 1145546..1145728 + 183 WP_096808992.1 hypothetical protein Toxin
BJG88_RS05465 1145932..1146345 + 414 WP_096808994.1 hypothetical protein -
BJG88_RS05470 1146556..1147941 + 1386 WP_096808996.1 class II fumarate hydratase -
BJG88_RS05475 1148201..1149028 - 828 WP_096808998.1 RluA family pseudouridine synthase -
BJG88_RS05480 1149226..1150335 + 1110 WP_096809000.1 GAF domain-containing sensor histidine kinase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(124-195)


Sequences


Toxin        


Download         Length: 61 a.a.        Molecular weight: 6910.28 Da        Isoelectric Point: 3.8145

>T66830 WP_096808992.1 NZ_CP017459:1145546-1145728 [Staphylococcus nepalensis]
MRNDSTKNQLNHDTEVENEMVDGFEDVVELGKEMEQISEENDEDKLDKAHDASVRSDLDD

Download         Length: 183 bp

>T66830 NZ_CP017459:1145546-1145728 [Staphylococcus nepalensis]
ATGAGAAATGATAGTACTAAAAACCAATTAAATCATGATACTGAAGTAGAAAATGAAATGGTTGATGGTTTTGAAGATGT
TGTAGAGTTAGGTAAAGAAATGGAACAAATTTCTGAAGAAAACGACGAAGATAAGCTAGATAAAGCACATGATGCAAGCG
TGCGTTCAGATTTAGATGATTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22323.12 Da        Isoelectric Point: 4.9602

>AT66830 WP_096808990.1 NZ_CP017459:1144923-1145522 [Staphylococcus nepalensis]
MAMNFKVLENERIVAEYAADILRKQFNNNPTTIAGVHLSNDNAPVLDELKKNIDNNAVDFSQINILDYDSNKSYFEALGV
PEGQIYGISYGEDTESFISDKIKTKENKGKLITQILSIDTNSRLNVSINHGLFSAREVILVITGSEKKNIVHKLYEENGK
TSFEPADLKAHRMVNVILDEAAAEGLPEDVRHYFTARFA

Download         Length: 600 bp

>AT66830 NZ_CP017459:1144923-1145522 [Staphylococcus nepalensis]
ATGGCAATGAACTTTAAAGTTTTAGAAAATGAAAGAATCGTAGCAGAATATGCTGCTGATATTTTAAGAAAACAATTTAA
CAATAATCCAACAACTATTGCTGGTGTGCACCTTTCTAATGATAATGCACCAGTATTAGATGAACTAAAGAAAAATATAG
ATAATAATGCTGTAGATTTTAGTCAAATTAATATATTAGACTATGACAGTAATAAGTCATATTTTGAAGCATTAGGTGTA
CCAGAAGGCCAAATTTACGGTATTTCTTATGGCGAAGACACAGAATCATTTATAAGTGACAAGATTAAAACTAAAGAAAA
TAAAGGTAAATTGATTACGCAAATACTTTCTATTGATACAAATAGTCGACTTAATGTAAGTATTAATCATGGTCTGTTTT
CTGCAAGAGAAGTTATATTGGTCATTACTGGTAGTGAGAAAAAAAATATTGTTCATAAATTATACGAAGAAAATGGTAAG
ACTTCATTTGAACCCGCTGATTTAAAAGCGCATCGCATGGTTAATGTTATTTTGGATGAAGCAGCTGCAGAAGGTCTGCC
AGAAGATGTTCGTCACTATTTCACTGCACGTTTTGCATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References