Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 993604..994133 Replicon chromosome
Accession NZ_CP017459
Organism Staphylococcus nepalensis strain JS9

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag BJG88_RS04575 Protein ID WP_096808815.1
Coordinates 993771..994133 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag BJG88_RS04570 Protein ID WP_096808814.1
Coordinates 993604..993774 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJG88_RS04545 989387..989866 + 480 WP_096808809.1 PH domain-containing protein -
BJG88_RS04550 989859..991364 + 1506 WP_096808810.1 PH domain-containing protein -
BJG88_RS04555 991357..991839 + 483 WP_108909235.1 PH domain-containing protein -
BJG88_RS04560 991902..992252 + 351 WP_096808812.1 holo-ACP synthase -
BJG88_RS04565 992368..993516 + 1149 WP_096808813.1 alanine racemase -
BJG88_RS04570 993604..993774 + 171 WP_096808814.1 antitoxin MazE Antitoxin
BJG88_RS04575 993771..994133 + 363 WP_096808815.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BJG88_RS04580 994470..995471 + 1002 WP_108909236.1 PP2C family protein-serine/threonine phosphatase -
BJG88_RS04585 995540..995866 + 327 WP_096808817.1 anti-sigma factor antagonist -
BJG88_RS04590 995868..996350 + 483 WP_096808818.1 anti-sigma B factor RsbW -
BJG88_RS04595 996325..997095 + 771 WP_096808819.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13581.66 Da        Isoelectric Point: 9.9426

>T66829 WP_096808815.1 NZ_CP017459:993771-994133 [Staphylococcus nepalensis]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDEKMQEVNNAIDISLGLHNIRNHRT

Download         Length: 363 bp

>T66829 NZ_CP017459:993771-994133 [Staphylococcus nepalensis]
ATGATGAGAAGAGGCGACGTTTATTTAGCTGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAATAAGACCCGTAGT
CATTATACAAAATGATACTGGTAATAAATATAGTCCTACCGTAATTGTAGCTGCAATTACTGGTAGGATTAATAAGGCTA
AAATACCTACACATGTAGAAATAGAAAAAAGCAAGTATAAACTCGACAAAGACTCTGTTATTTTGTTAGAGCAAATACGT
ACTTTAGATAAAAACAGATTGAAAGAGAAATTAACATATTTATCTGATGAAAAAATGCAAGAGGTAAATAATGCTATAGA
TATTAGCTTAGGATTACATAATATTAGAAATCATAGAACATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6355.98 Da        Isoelectric Point: 4.1920

>AT66829 WP_096808814.1 NZ_CP017459:993604-993774 [Staphylococcus nepalensis]
MASFNQNRNHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYISSKHNNE

Download         Length: 171 bp

>AT66829 NZ_CP017459:993604-993774 [Staphylococcus nepalensis]
ATGGCAAGTTTTAATCAAAACAGAAATCATAGTATTGAACAACTTTTAAAAGAAGGCTATTCACAAATGGCTGACTTGAA
TCTCTCCCTTGCGGCGGAAGCATTTCCATTTGAATGTGAAGCTTGCGATTGCAATGAAGTCTACATTAGCTCTAAGCATA
ACAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References