Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 981655..982169 Replicon chromosome
Accession NZ_CP017459
Organism Staphylococcus nepalensis strain JS9

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag BJG88_RS04510 Protein ID WP_096808803.1
Coordinates 981963..982169 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag BJG88_RS04505 Protein ID WP_096808802.1
Coordinates 981655..981948 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJG88_RS04485 977326..977964 + 639 WP_096808798.1 thiamine phosphate synthase -
BJG88_RS04490 978052..978921 + 870 WP_096808799.1 membrane protein insertase YidC -
BJG88_RS04495 979056..979709 - 654 WP_108909233.1 HD domain-containing protein -
BJG88_RS04500 980029..981513 - 1485 WP_108909234.1 cardiolipin synthase -
BJG88_RS04505 981655..981948 + 294 WP_096808802.1 copper-sensing transcriptional repressor CsoR Antitoxin
BJG88_RS04510 981963..982169 + 207 WP_096808803.1 heavy-metal-associated domain-containing protein Toxin
BJG88_RS04515 982493..982633 + 141 WP_002482742.1 hypothetical protein -
BJG88_RS04520 982779..983078 - 300 WP_096808804.1 transposase -
BJG88_RS04525 983213..984406 - 1194 WP_096808805.1 rod shape-determining protein RodA -
BJG88_RS04530 984668..985738 + 1071 WP_096808806.1 D-alanine--D-alanine ligase -
BJG88_RS04535 985751..987106 + 1356 WP_096808807.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(20-65)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7919.04 Da        Isoelectric Point: 4.6472

>T66828 WP_096808803.1 NZ_CP017459:981963-982169 [Staphylococcus nepalensis]
MNSQAIYIKNIENEANKIQIESHLAQLIGVYNVSVDKDYKRVLIDFKTPANLNNLEKEIYDLGFEILY

Download         Length: 207 bp

>T66828 NZ_CP017459:981963-982169 [Staphylococcus nepalensis]
ATGAATTCACAAGCGATTTATATAAAAAACATAGAAAATGAAGCAAACAAAATTCAAATTGAAAGTCATTTGGCGCAACT
TATAGGCGTATACAATGTTTCAGTTGATAAAGATTATAAGCGAGTGCTTATTGATTTTAAAACACCTGCAAATTTAAATA
ATTTAGAAAAAGAAATATATGATTTAGGTTTTGAAATTTTATACTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11144.73 Da        Isoelectric Point: 6.8617

>AT66828 WP_096808802.1 NZ_CP017459:981655-981948 [Staphylococcus nepalensis]
MAETQKAHHSEQTKSNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNQGEQ
QEAMDELLVTFQKLMKD

Download         Length: 294 bp

>AT66828 NZ_CP017459:981655-981948 [Staphylococcus nepalensis]
ATGGCAGAAACGCAAAAAGCACACCATTCTGAACAAACTAAATCCAATTTAAAGTCTAGATTAAATCGTATCGAAGGCCA
AGTAAAAGCAATCAACCGCATGATAGATGAAGATGTATACTGTGATGATGTACTCACACAAATTAGAGCGACAAGATCTG
CTTTAAATAGCGTTGCAACAAAACTATTAGATCATCATATGAAGAGTTGTATCATGGACAAGGTCAATCAGGGCGAGCAG
CAAGAGGCTATGGATGAACTGTTAGTTACTTTTCAAAAATTGATGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References