66823

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3903082..3904922 Replicon chromosome
Accession NZ_CP017454
Organism Dickeya solani strain PPO 9019

Toxin (Protein)


Gene name hipA Uniprot ID A0A2K8VX87
Locus tag BJJ98_RS17200 Protein ID WP_022634631.1
Coordinates 3903082..3904428 (+) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag BJJ98_RS17205 Protein ID WP_099048985.1
Coordinates 3904539..3904922 (+) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJJ98_RS17180 3898704..3900188 - 1485 WP_022634635.1 NCS1 family nucleobase:cation symporter-1 -
BJJ98_RS17185 3900341..3901084 + 744 WP_022634634.1 GntR family transcriptional regulator -
BJJ98_RS17190 3901081..3901818 + 738 WP_022634633.1 allantoin racemase -
BJJ98_RS17195 3901862..3902809 + 948 WP_022634632.1 allantoinase PuuE -
BJJ98_RS17200 3903082..3904428 + 1347 WP_022634631.1 type II toxin-antitoxin system HipA family toxin Toxin
BJJ98_RS17205 3904539..3904922 + 384 WP_099048985.1 helix-turn-helix domain-containing protein Antitoxin
BJJ98_RS17210 3904974..3905354 - 381 WP_022634629.1 oxalurate catabolism protein HpxZ -
BJJ98_RS17215 3905351..3906763 - 1413 WP_022634628.1 AtzE family amidohydrolase -
BJJ98_RS17220 3906760..3906957 - 198 WP_022634627.1 oxalurate catabolism protein HpxX -
BJJ98_RS17225 3907002..3908591 - 1590 WP_022634626.1 gamma-glutamyltransferase family protein -
BJJ98_RS17230 3908766..3909605 + 840 WP_022634625.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(165-392)

Antitoxin

Cro/C1-type helix-turn-helix domain

(51-104)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 50541.28 Da        Isoelectric Point: 4.9663

>T66823 WP_022634631.1 NZ_CP017454:3903082-3904428 [Dickeya solani]
MERLTVQAFIDNAWQDIAEIGFPESDQDNYLLTRLDYASDYGLDYMDCDDHHAVSVNYPVRIFFDDGGELGWMRFLDDIM
PAGASRKYWVDHLDLSGLPAPLQNYVLLRHATIAPVGNLRIKESIPVRHEGATRFFSVEDVKNRAADFLDYAQQRGAAAG
GATGAGGEAPKLLLRCNADDRVWIDTWQDKTDCRDTAYLVKFPRGQRSEIDCDILRAEFHYYHELAAMGFDTIPVAGMRL
EEGRHYPSLWLPRFDIEFPGDGRVKRYGMESVYSLLRAGPGSALRHDQTIRAVIAKIASSHTVSVEGKPFDQAAFVIEWV
RRDVLNIAFGNSDNHGRNTAFLKDEQGIRLAPIYDFAPMKADPAGIARATKWPEPLEIGGDYQFEWIAEQLSDMLPPALL
MERLRETAVQLVGLKARLQARGVPESILTMPSIGFDYLPEKLQRWGLL

Download         Length: 1347 bp

>T66823 NZ_CP017454:3903082-3904428 [Dickeya solani]
ATGGAACGACTGACTGTACAGGCGTTTATCGATAATGCGTGGCAGGATATTGCCGAGATCGGTTTTCCCGAGAGCGACCA
GGATAATTACCTGCTGACCCGGCTGGATTATGCGTCCGATTATGGCCTTGACTATATGGATTGCGACGACCACCACGCGG
TTTCCGTCAATTACCCGGTTCGGATCTTCTTTGATGATGGCGGTGAGCTCGGATGGATGCGCTTTCTGGATGACATCATG
CCGGCGGGGGCCAGCCGAAAATATTGGGTTGACCACCTTGATCTCTCGGGGCTGCCGGCACCGTTGCAAAATTATGTCTT
GCTGCGGCATGCCACCATCGCACCGGTCGGTAATTTGCGCATCAAGGAGTCGATTCCTGTGCGGCATGAAGGTGCAACCC
GCTTTTTCAGCGTGGAGGATGTGAAGAACCGGGCTGCCGATTTTCTGGATTATGCGCAGCAGCGCGGTGCCGCTGCCGGG
GGCGCTACAGGGGCGGGCGGTGAGGCGCCAAAGCTGCTGTTGCGTTGTAATGCCGACGATCGGGTGTGGATCGATACCTG
GCAGGATAAGACCGACTGCCGCGATACCGCCTATCTGGTGAAGTTTCCGCGCGGGCAACGCAGTGAGATTGACTGCGACA
TCCTGCGGGCCGAGTTTCATTACTACCATGAATTAGCCGCGATGGGGTTCGACACCATTCCTGTGGCGGGCATGCGTCTG
GAAGAGGGGCGGCATTACCCGTCGCTCTGGTTGCCGCGTTTTGATATCGAATTCCCCGGCGATGGGCGCGTGAAGCGTTA
TGGCATGGAATCAGTTTATTCCCTGTTGCGGGCCGGGCCGGGCAGCGCGCTGCGGCACGATCAAACGATTCGGGCGGTGA
TCGCCAAAATAGCGTCCAGCCATACGGTCAGCGTCGAGGGAAAGCCATTCGACCAAGCGGCGTTCGTGATCGAGTGGGTG
CGCCGCGATGTGCTGAATATTGCCTTCGGCAACAGCGATAACCACGGCCGCAATACCGCGTTTCTCAAGGACGAACAGGG
GATTCGGCTGGCGCCGATTTACGACTTCGCGCCGATGAAGGCCGACCCGGCAGGCATTGCCAGAGCGACCAAATGGCCGG
AGCCGCTGGAAATCGGCGGTGATTATCAGTTTGAGTGGATCGCGGAGCAGTTGTCCGACATGCTCCCGCCGGCGCTGTTG
ATGGAGAGATTGCGCGAGACGGCGGTGCAACTGGTTGGACTGAAAGCGCGGCTTCAGGCGCGCGGTGTGCCCGAGTCGAT
CCTAACCATGCCTTCCATCGGGTTTGATTACCTTCCTGAAAAGCTACAGCGGTGGGGGTTGTTATGA

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 13731.06 Da        Isoelectric Point: 10.8242

>AT66823 WP_099048985.1 NZ_CP017454:3904539-3904922 [Dickeya solani]
MLRPPVIAVAETADIPKARASKNSRPLNASERQSAMQSIIRRMMVGEISQGNALRELRLSVLGLKQDAYASLVGVSRKTL
SEIENDKGNYTADIINKVFKPFGLKMGLIPVSPSLLAEILATAPASR

Download         Length: 384 bp

>AT66823 NZ_CP017454:3904539-3904922 [Dickeya solani]
ATGCTGCGTCCCCCGGTCATTGCCGTGGCGGAGACGGCGGATATTCCCAAAGCGAGAGCATCAAAAAATTCCAGACCACT
CAATGCCAGTGAGAGACAGTCTGCGATGCAAAGCATTATCCGCAGGATGATGGTCGGGGAGATATCGCAGGGAAACGCGC
TCAGGGAATTGCGTCTCAGCGTTCTGGGGCTCAAGCAGGATGCCTACGCCAGTCTGGTAGGCGTGTCGCGCAAGACCTTG
TCCGAAATCGAGAATGACAAAGGCAATTACACGGCGGATATCATCAACAAGGTCTTTAAACCCTTTGGTCTGAAGATGGG
ATTAATTCCGGTATCGCCTTCTTTGCTCGCCGAGATACTCGCCACCGCGCCAGCCTCTCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8VX87

Antitoxin

Source ID Structure

References