66820

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2151863..2152389 Replicon chromosome
Accession NZ_CP017454
Organism Dickeya solani strain PPO 9019

Toxin (Protein)


Gene name ccdB Uniprot ID A0A2K8W1W4
Locus tag BJJ98_RS09435 Protein ID WP_022632051.1
Coordinates 2152084..2152389 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A2K8W1V7
Locus tag BJJ98_RS09430 Protein ID WP_022632052.1
Coordinates 2151863..2152081 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJJ98_RS09400 2147125..2147700 + 576 WP_022632056.1 transcriptional regulator -
BJJ98_RS09410 2148098..2149357 + 1260 WP_022632055.1 integrase arm-type DNA-binding domain-containing protein -
BJJ98_RS22020 2149497..2149685 - 189 WP_033111580.1 hypothetical protein -
BJJ98_RS09415 2149808..2150158 + 351 WP_013316250.1 hypothetical protein -
BJJ98_RS09425 2151061..2151804 + 744 WP_022632053.1 hypothetical protein -
BJJ98_RS09430 2151863..2152081 + 219 WP_022632052.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
BJJ98_RS09435 2152084..2152389 + 306 WP_022632051.1 type II toxin-antitoxin system toxin CcdB Toxin
BJJ98_RS09440 2152879..2154819 - 1941 WP_022632050.1 hypothetical protein -
BJJ98_RS09445 2154807..2155373 - 567 WP_024103901.1 hypothetical protein -
BJJ98_RS09450 2155377..2156648 - 1272 WP_022632048.1 hypothetical protein -
BJJ98_RS09455 2156764..2157161 - 398 Protein_1839 DUF3577 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2147921..2158240 10319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11779.68 Da        Isoelectric Point: 4.8837

>T66820 WP_022632051.1 NZ_CP017454:2152084-2152389 [Dickeya solani]
MQFIVYEYKRASHYKMFVDVQSDIVETPKRRMVIPLIEAHHLSEKVNKTLFPKIRIDGEDYRLMTTELSSVPVEVMGEVI
ADLGDYADEIKDAINLMFWGI

Download         Length: 306 bp

>T66820 NZ_CP017454:2152084-2152389 [Dickeya solani]
ATGCAATTCATTGTTTATGAATACAAACGAGCCAGTCACTACAAAATGTTTGTCGATGTGCAGAGTGATATCGTCGAGAC
ACCCAAGCGGCGCATGGTCATTCCGCTTATCGAAGCACACCACCTGTCTGAGAAAGTGAATAAGACGTTGTTCCCTAAGA
TCCGCATCGACGGCGAAGATTATCGGCTGATGACGACTGAACTATCGAGCGTACCTGTTGAAGTCATGGGTGAAGTGATT
GCGGATCTTGGCGACTACGCGGATGAGATTAAGGATGCTATTAATCTTATGTTTTGGGGGATTTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8109.02 Da        Isoelectric Point: 5.8316

>AT66820 WP_022632052.1 NZ_CP017454:2151863-2152081 [Dickeya solani]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDAIGKEARRIKAEEWKKENSEGMEEVARFIAQNGSFADENRNW

Download         Length: 219 bp

>AT66820 NZ_CP017454:2151863-2152081 [Dickeya solani]
ATGAAACACCGCGTCAGTGTTACCGTAGACAAAGACAACTATCAGGTTCTGAGTGCTGCCGGAGTCAACATTTCTGGGCT
GGTGAACGATGCCATTGGCAAAGAAGCCCGCCGTATCAAGGCTGAGGAGTGGAAGAAAGAAAACAGTGAGGGGATGGAGG
AAGTCGCCCGATTTATCGCGCAGAATGGCTCCTTTGCGGATGAAAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W1W4

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W1V7

References