66816

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 982459..983076 Replicon chromosome
Accession NZ_CP017454
Organism Dickeya solani strain PPO 9019

Toxin (Protein)


Gene name hicA Uniprot ID C6CDL0
Locus tag BJJ98_RS04315 Protein ID WP_012764944.1
Coordinates 982459..982638 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2K8W4Y6
Locus tag BJJ98_RS04320 Protein ID WP_022633005.1
Coordinates 982666..983076 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJJ98_RS04300 980384..981439 + 1056 WP_022633006.1 MBL fold metallo-hydrolase -
BJJ98_RS04310 981775..982137 - 363 WP_071598627.1 hypothetical protein -
BJJ98_RS04315 982459..982638 + 180 WP_012764944.1 type II toxin-antitoxin system HicA family toxin Toxin
BJJ98_RS04320 982666..983076 + 411 WP_022633005.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BJJ98_RS04325 983079..983744 - 666 WP_022633004.1 RraA family protein -
BJJ98_RS04330 983741..984586 - 846 WP_023637730.1 ABC transporter ATP-binding protein -
BJJ98_RS04335 984598..985647 - 1050 WP_022633002.1 iron ABC transporter permease -
BJJ98_RS04340 985640..986662 - 1023 WP_022633001.1 iron ABC transporter permease -
BJJ98_RS04345 986659..987576 - 918 WP_023637727.1 iron-siderophore ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6530.61 Da        Isoelectric Point: 10.7838

>T66816 WP_012764944.1 NZ_CP017454:982459-982638 [Dickeya solani]
MDSRTLIAEIKADGWELVRVNGSHHHFTHPTKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Download         Length: 180 bp

>T66816 NZ_CP017454:982459-982638 [Dickeya solani]
ATGGACAGCAGGACGCTAATAGCAGAAATCAAGGCCGATGGATGGGAACTGGTAAGGGTTAACGGCAGTCATCACCATTT
TACCCACCCAACCAAACCGGGATTAGTGACCATCCCACACCCGAAGAAGGATTTACCGATAGGTACGGTAAAAAGCATCA
GGAAACAAGCGGGAATATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14499.48 Da        Isoelectric Point: 4.3391

>AT66816 WP_022633005.1 NZ_CP017454:982666-983076 [Dickeya solani]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDEAIANAKDAITGHIELLIEMGQDIPAVSSVGTLAKAPEYTGYTWAV
VDIDVTRLMGGAEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSIR

Download         Length: 411 bp

>AT66816 NZ_CP017454:982666-983076 [Dickeya solani]
ATGTTTTATCCCATTGCAATTGAAGCAGGCGACGATACTCATGCCTACGGCGTGACAGTGCCGGATCTGCCGGGCTGTTT
CTCCGCAGGTGATACGCTTGATGAGGCCATCGCCAATGCCAAAGACGCGATCACCGGCCATATCGAGCTGCTGATCGAGA
TGGGTCAGGATATTCCTGCTGTGTCATCAGTCGGAACGCTGGCGAAAGCACCGGAGTACACCGGTTACACCTGGGCTGTT
GTTGATATCGATGTCACCCGGCTGATGGGTGGGGCAGAGAAAATTAATGTCACGTTGCCGAAATCGCTGATTGACCGTAT
TGACCGTTGCGTAGCGAGTAACCCGGAATTTAAGAGCCGCTCAGGGTTCCTTGCTCAGGCAGCGTTAGAGCGGATTTCAT
CCATTCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W4W9

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W4Y6

References