Detailed information of TA system TA066804

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 3910621..3912461
• Replicon: chromosome
• Accession: NZ_CP017453
• Organism: Dickeya solani D s0432-1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A2K8VX87
• Locus tag: BJD21_RS17230
• Protein ID: WP_022634631.1
• Coordinates: 3910621..3911967 (+)
• Length: 449 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: BJD21_RS17235
• Protein ID: WP_099048985.1
• Coordinates: 3912078..3912461 (+)
• Length: 128 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BJD21_RS17210	3906243..3907727	-	1485	WP_022634635.1	NCS1 family nucleobase:cation symporter-1	-
BJD21_RS17215	3907880..3908623	+	744	WP_022634634.1	GntR family transcriptional regulator	-
BJD21_RS17220	3908620..3909357	+	738	WP_022634633.1	allantoin racemase	-
BJD21_RS17225	3909401..3910348	+	948	WP_022634632.1	allantoinase PuuE	-
BJD21_RS17230	3910621..3911967	+	1347	WP_022634631.1	type II toxin-antitoxin system HipA family toxin	Toxin
BJD21_RS17235	3912078..3912461	+	384	WP_099048985.1	helix-turn-helix domain-containing protein	Antitoxin
BJD21_RS17240	3912513..3912893	-	381	WP_022634629.1	oxalurate catabolism protein HpxZ	-
BJD21_RS17245	3912890..3914302	-	1413	WP_022634628.1	AtzE family amidohydrolase	-
BJD21_RS17250	3914299..3914496	-	198	WP_022634627.1	oxalurate catabolism protein HpxX	-
BJD21_RS17255	3914541..3916130	-	1590	WP_022634626.1	gamma-glutamyltransferase family protein	-
BJD21_RS17260	3916305..3917144	+	840	WP_022634625.1	MurR/RpiR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (165-392)

Antitoxin

• Cro/C1-type helix-turn-helix domain (51-104)

Sequences

Toxin

Protein

• Length: 449 a.a.
• Molecular weight: 50541.28 Da
• Isoelectric Point: 4.9663

>T66804 WP_022634631.1 NZ_CP017453:3910621-3911967 [Dickeya solani D s0432-1]
MERLTVQAFIDNAWQDIAEIGFPESDQDNYLLTRLDYASDYGLDYMDCDDHHAVSVNYPVRIFFDDGGELGWMRFLDDIM
PAGASRKYWVDHLDLSGLPAPLQNYVLLRHATIAPVGNLRIKESIPVRHEGATRFFSVEDVKNRAADFLDYAQQRGAAAG
GATGAGGEAPKLLLRCNADDRVWIDTWQDKTDCRDTAYLVKFPRGQRSEIDCDILRAEFHYYHELAAMGFDTIPVAGMRL
EEGRHYPSLWLPRFDIEFPGDGRVKRYGMESVYSLLRAGPGSALRHDQTIRAVIAKIASSHTVSVEGKPFDQAAFVIEWV
RRDVLNIAFGNSDNHGRNTAFLKDEQGIRLAPIYDFAPMKADPAGIARATKWPEPLEIGGDYQFEWIAEQLSDMLPPALL
MERLRETAVQLVGLKARLQARGVPESILTMPSIGFDYLPEKLQRWGLL

Nucleotide

• Length: 1347 bp

>T66804 NZ_CP017453:3910621-3911967 [Dickeya solani D s0432-1]
ATGGAACGACTGACTGTACAGGCGTTTATCGATAATGCGTGGCAGGATATTGCCGAGATCGGTTTTCCCGAGAGCGACCA
GGATAATTACCTGCTGACCCGGCTGGATTATGCGTCCGATTATGGCCTTGACTATATGGATTGCGACGACCACCACGCGG
TTTCCGTCAATTACCCGGTTCGGATCTTCTTTGATGATGGCGGTGAGCTCGGATGGATGCGCTTTCTGGATGACATCATG
CCGGCGGGGGCCAGCCGAAAATATTGGGTTGACCACCTTGATCTCTCGGGGCTGCCGGCACCGTTGCAAAATTATGTCTT
GCTGCGGCATGCCACCATCGCACCGGTCGGTAATTTGCGCATCAAGGAGTCGATTCCTGTGCGGCATGAAGGTGCAACCC
GCTTTTTCAGCGTGGAGGATGTGAAGAACCGGGCTGCCGATTTTCTGGATTATGCGCAGCAGCGCGGTGCCGCTGCCGGG
GGCGCTACAGGGGCGGGCGGTGAGGCGCCAAAGCTGCTGTTGCGTTGTAATGCCGACGATCGGGTGTGGATCGATACCTG
GCAGGATAAGACCGACTGCCGCGATACCGCCTATCTGGTGAAGTTTCCGCGCGGGCAACGCAGTGAGATTGACTGCGACA
TCCTGCGGGCCGAGTTTCATTACTACCATGAATTAGCCGCGATGGGGTTCGACACCATTCCTGTGGCGGGCATGCGTCTG
GAAGAGGGGCGGCATTACCCGTCGCTCTGGTTGCCGCGTTTTGATATCGAATTCCCCGGCGATGGGCGCGTGAAGCGTTA
TGGCATGGAATCAGTTTATTCCCTGTTGCGGGCCGGGCCGGGCAGCGCGCTGCGGCACGATCAAACGATTCGGGCGGTGA
TCGCCAAAATAGCGTCCAGCCATACGGTCAGCGTCGAGGGAAAGCCATTCGACCAAGCGGCGTTCGTGATCGAGTGGGTG
CGCCGCGATGTGCTGAATATTGCCTTCGGCAACAGCGATAACCACGGCCGCAATACCGCGTTTCTCAAGGACGAACAGGG
GATTCGGCTGGCGCCGATTTACGACTTCGCGCCGATGAAGGCCGACCCGGCAGGCATTGCCAGAGCGACCAAATGGCCGG
AGCCGCTGGAAATCGGCGGTGATTATCAGTTTGAGTGGATCGCGGAGCAGTTGTCCGACATGCTCCCGCCGGCGCTGTTG
ATGGAGAGATTGCGCGAGACGGCGGTGCAACTGGTTGGACTGAAAGCGCGGCTTCAGGCGCGCGGTGTGCCCGAGTCGAT
CCTAACCATGCCTTCCATCGGGTTTGATTACCTTCCTGAAAAGCTACAGCGGTGGGGGTTGTTATGA

Antitoxin

Protein

• Length: 128 a.a.
• Molecular weight: 13731.06 Da
• Isoelectric Point: 10.8242

>AT66804 WP_099048985.1 NZ_CP017453:3912078-3912461 [Dickeya solani D s0432-1]
MLRPPVIAVAETADIPKARASKNSRPLNASERQSAMQSIIRRMMVGEISQGNALRELRLSVLGLKQDAYASLVGVSRKTL
SEIENDKGNYTADIINKVFKPFGLKMGLIPVSPSLLAEILATAPASR

Nucleotide

• Length: 384 bp

>AT66804 NZ_CP017453:3912078-3912461 [Dickeya solani D s0432-1]
ATGCTGCGTCCCCCGGTCATTGCCGTGGCGGAGACGGCGGATATTCCCAAAGCGAGAGCATCAAAAAATTCCAGACCACT
CAATGCCAGTGAGAGACAGTCTGCGATGCAAAGCATTATCCGCAGGATGATGGTCGGGGAGATATCGCAGGGAAACGCGC
TCAGGGAATTGCGTCTCAGCGTTCTGGGGCTCAAGCAGGATGCCTACGCCAGTCTGGTAGGCGTGTCGCGCAAGACCTTG
TCCGAAATCGAGAATGACAAAGGCAATTACACGGCGGATATCATCAACAAGGTCTTTAAACCCTTTGGTCTGAAGATGGG
ATTAATTCCGGTATCGCCTTCTTTGCTCGCCGAGATACTCGCCACCGCGCCAGCCTCTCGTTAG

Structures

Toxin

• AlphaFold DB: A0A2K8VX87