Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2761939..2763527 Replicon chromosome
Accession NZ_CP017453
Organism Dickeya solani D s0432-1

Toxin (Protein)


Gene name hipA Uniprot ID A0A2K8W078
Locus tag BJD21_RS12320 Protein ID WP_022635525.1
Coordinates 2761939..2763258 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2K8W0B1
Locus tag BJD21_RS12325 Protein ID WP_022635524.1
Coordinates 2763258..2763527 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJD21_RS12295 2758014..2758154 + 141 WP_004093983.1 50S ribosomal protein L34 -
BJD21_RS12300 2758173..2758532 + 360 WP_022635528.1 ribonuclease P protein component -
BJD21_RS12305 2758496..2758753 + 258 WP_071598660.1 membrane protein insertion efficiency factor YidD -
BJD21_RS12310 2758756..2760387 + 1632 WP_022635527.1 membrane protein insertase YidC -
BJD21_RS12315 2760503..2761867 + 1365 WP_022635526.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
BJD21_RS12320 2761939..2763258 - 1320 WP_022635525.1 type II toxin-antitoxin system HipA family toxin Toxin
BJD21_RS12325 2763258..2763527 - 270 WP_022635524.1 helix-turn-helix domain-containing protein Antitoxin
BJD21_RS12330 2763798..2764754 - 957 WP_026595316.1 helix-turn-helix domain-containing protein -
BJD21_RS12335 2764798..2765571 - 774 WP_022635522.1 MBL fold metallo-hydrolase -
BJD21_RS12340 2765886..2766971 + 1086 WP_022635521.1 4-hydroxyphenylpyruvate dioxygenase -
BJD21_RS12345 2767070..2767456 - 387 WP_022635520.1 helix-turn-helix transcriptional regulator -
BJD21_RS12350 2767598..2768209 + 612 WP_022635519.1 NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49161.32 Da        Isoelectric Point: 6.6616

>T66803 WP_022635525.1 NZ_CP017453:c2763258-2761939 [Dickeya solani D s0432-1]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLELPGSRPLSLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVTRHQ
ADSTQPFDLLAKVGQDSVGALQLVPQGTAVGDIKQIEYKTLSEQQLENILAGYLSDAPLGMIDTEEDFRISIAGAQEKTA
LLYLDGSWCLPLNTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLSVPHCFMITAGKIKALAVERFDRK
YASDGRWIMRLPQEDFCQVLNVPSARKYENHGGPGISAIMSVLLGAIEPERDRYTFMKAQVLFWLLAATDGHAKNFSLFI
EFEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLTGSKGKKYAIEQIFPRHFFQTAKVVGFARESMERILTEFSQTV
DSVIVSVRNQLPADFPTPIRDAILGGLQTRSSRLTTGWE

Download         Length: 1320 bp

>T66803 NZ_CP017453:c2763258-2761939 [Dickeya solani D s0432-1]
ATGGCGGCGCTCGATGTTTACATGAACGGCTACCGGGTGGGAATTCTGACCAAAACGGGCAGTGGCGCGCATCATTTTTC
CTATGATGCGAACTGGCTCGAGTTGCCGGGGAGTCGCCCCCTCTCGCTCTCAATGCCGCTACGCCATCAGCCCTATCAAG
GTGATGAAGTTTATAATTTCTTCGACAACTTGTTGCCGGATAACCCGGATATCAGGCGGCGGATTGTCACCAGGCATCAG
GCGGATTCCACCCAGCCGTTTGATTTGCTGGCTAAAGTGGGGCAAGACAGTGTTGGGGCGTTGCAATTGGTGCCGCAGGG
CACCGCTGTTGGCGATATAAAACAGATCGAATACAAAACCTTATCCGAGCAACAGCTTGAAAACATACTGGCGGGATATC
TGTCCGATGCCCCGCTCGGGATGATTGATACAGAAGAGGATTTTCGTATCTCTATCGCAGGCGCACAGGAAAAGACGGCG
CTGCTTTATCTGGATGGCAGCTGGTGTTTGCCTCTTAATACCACACCAACTACCCACATCATCAAGCTACCGATTGGTAA
AATTGAGAGTCATTCATACTCAATTGATATGTCTGACAGCGTTGAAAATGAATACCTGTGCCTGCTCATTGCCAAGGCGT
TTGGGCTGTCGGTACCGCACTGTTTTATGATCACAGCAGGCAAGATAAAAGCGCTGGCGGTAGAACGTTTTGATCGTAAA
TACGCCTCGGATGGTCGTTGGATTATGCGGTTGCCGCAGGAGGATTTTTGCCAGGTATTAAACGTGCCTTCCGCACGAAA
ATACGAAAATCATGGTGGACCGGGCATTTCCGCTATTATGTCGGTGCTATTAGGGGCGATTGAACCTGAAAGGGATCGCT
ATACCTTTATGAAGGCGCAGGTGCTGTTTTGGCTATTGGCTGCAACGGATGGACATGCAAAAAACTTCTCCCTGTTTATT
GAATTTGAAGGACGATATCGCCTCACGCCTTTCTATGACATTCTCTCTATGTACCCGGCGATGGGCGGGCGGGGAATTGA
CCGCAGAGAGGCCAAACTGGCGATGGGGCTGACCGGCTCAAAAGGCAAGAAATACGCCATTGAGCAGATCTTTCCACGGC
ACTTTTTCCAAACGGCAAAGGTGGTTGGATTTGCCAGAGAATCGATGGAACGCATTCTGACTGAATTTTCACAGACGGTT
GATTCTGTCATCGTGAGTGTCAGAAACCAACTGCCTGCGGATTTTCCCACTCCTATCCGCGATGCGATCCTGGGAGGGCT
ACAGACTAGATCGAGTCGATTGACGACGGGCTGGGAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9950.26 Da        Isoelectric Point: 10.0983

>AT66803 WP_022635524.1 NZ_CP017453:c2763527-2763258 [Dickeya solani D s0432-1]
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTITPRNAHAANNEASV
ATSAWKEEW

Download         Length: 270 bp

>AT66803 NZ_CP017453:c2763527-2763258 [Dickeya solani D s0432-1]
ATGAAGGTCACCAACAGCAAACAGCTTAGCAGCTATCTAAAAGATGTTCGTATCACGCAGAAGCTTTCCCAAGGGAAAGT
GGCCAGTAAAGTGGGGATTCGTCAGGACACGGTATCGAGCTTCGAACAACATCCCGATTCCACCAAGCTGGAAACCTTCT
TTAAGATCCTGTCGGCATTAAATTTAGAACTTACCATTACCCCCAGAAATGCGCATGCAGCCAATAACGAGGCTTCTGTT
GCAACATCAGCCTGGAAGGAAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W078

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W0B1

References