Detailed information of TA system TA066802

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 2163996..2164780
• Replicon: chromosome
• Accession: NZ_CP017453
• Organism: Dickeya solani D s0432-1

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: BJD21_RS09480
• Protein ID: WP_022632047.1
• Coordinates: 2163996..2164490 (-)
• Length: 165 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: A0A2K8W1V4
• Locus tag: BJD21_RS09485
• Protein ID: WP_022632046.1
• Coordinates: 2164487..2164780 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BJD21_RS09460	2159656..2161596	-	1941	WP_022632050.1	hypothetical protein	-
BJD21_RS09465	2161584..2162156	-	573	WP_022632049.1	hypothetical protein	-
BJD21_RS09470	2162160..2163431	-	1272	WP_022632048.1	hypothetical protein	-
BJD21_RS09475	2163547..2163944	-	398	Protein_1845	DUF3577 domain-containing protein	-
BJD21_RS09480	2163996..2164490	-	495	WP_022632047.1	GNAT family N-acetyltransferase	Toxin
BJD21_RS09485	2164487..2164780	-	294	WP_022632046.1	DUF1778 domain-containing protein	Antitoxin
BJD21_RS09490	2165185..2166436	+	1252	Protein_1848	tyrosine-type recombinase/integrase	-
BJD21_RS09495	2167428..2168135	-	708	WP_022632044.1	SDR family oxidoreductase	-
BJD21_RS09500	2168163..2168459	-	297	WP_022632043.1	hypothetical protein	-
BJD21_RS09505	2168502..2168954	-	453	WP_022632042.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2154698..2165023	10325

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (66-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (5-95)

Sequences

Toxin

Protein

• Length: 165 a.a.
• Molecular weight: 17639.41 Da
• Isoelectric Point: 6.8524

>T66802 WP_022632047.1 NZ_CP017453:c2164490-2163996 [Dickeya solani D s0432-1]
MISAPEPLHAEHVLSSFCCGVESMDNWLKQRAMKNQVTGASRTFVSCDDSRVLAYYSLASSAVATTAAPGRFRRNMPDPI
PVVVLGRLAVDTSLHGQGVGRALVRDAGLRVIQVADTIGIRGMLVHALSDEARDFYLRVGFEPSPIDPMILMVTLGDLVG
SLSI

Nucleotide

• Length: 495 bp

>T66802 NZ_CP017453:c2164490-2163996 [Dickeya solani D s0432-1]
ATGATCTCTGCTCCTGAGCCACTCCACGCCGAACATGTACTATCTTCATTCTGTTGCGGTGTGGAGTCTATGGACAACTG
GCTGAAACAACGGGCGATGAAAAATCAGGTCACTGGCGCATCCCGAACTTTCGTCAGTTGCGATGATTCAAGAGTGTTGG
CGTATTACTCATTGGCTTCCAGCGCCGTGGCAACAACTGCCGCCCCCGGACGCTTTCGTCGCAATATGCCCGATCCGATC
CCGGTGGTAGTGCTGGGACGTCTGGCGGTTGATACGTCATTGCATGGTCAGGGCGTTGGCCGGGCGCTGGTGCGTGATGC
CGGGCTACGGGTGATTCAGGTAGCGGATACTATCGGCATTCGCGGGATGTTGGTTCATGCGCTGTCTGATGAAGCGCGTG
ATTTTTACCTACGAGTGGGGTTTGAACCTTCACCGATTGACCCGATGATTTTGATGGTAACGTTGGGGGATTTGGTGGGG
AGTTTATCAATTTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10942.53 Da
• Isoelectric Point: 9.8078

>AT66802 WP_022632046.1 NZ_CP017453:c2164780-2164487 [Dickeya solani D s0432-1]
MPVTNSVSVKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIDQRIIMADPDAYQEFLARLDQAPEPN
AALRKTMQTPAPWEQKK

Nucleotide

• Length: 294 bp

>AT66802 NZ_CP017453:c2164780-2164487 [Dickeya solani D s0432-1]
ATGCCAGTGACGAACAGCGTTTCTGTTAAACGCGAAACATTGAATTTACGCATCAAGCCCGCCGAACGCGATCTGATCGA
TCGTGCAGCGAAGGCCAGAGGAAAAAATCGTACTGATTTTGTTCTTGAGGCTGCTCGCGCCGCCGCAGAGGAAGCGTTGA
TCGATCAGCGTATCATCATGGCAGATCCAGATGCCTATCAGGAATTCCTTGCTCGCTTGGATCAGGCTCCTGAGCCAAAT
GCCGCGCTGCGTAAAACCATGCAAACGCCTGCACCGTGGGAACAGAAAAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A2K8W1V4