Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2158640..2159166 Replicon chromosome
Accession NZ_CP017453
Organism Dickeya solani D s0432-1

Toxin (Protein)


Gene name ccdB Uniprot ID A0A2K8W1W4
Locus tag BJD21_RS09455 Protein ID WP_022632051.1
Coordinates 2158861..2159166 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A2K8W1V7
Locus tag BJD21_RS09450 Protein ID WP_022632052.1
Coordinates 2158640..2158858 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJD21_RS09420 2153902..2154477 + 576 WP_022632056.1 transcriptional regulator -
BJD21_RS09430 2154875..2156134 + 1260 WP_022632055.1 integrase arm-type DNA-binding domain-containing protein -
BJD21_RS21740 2156274..2156462 - 189 WP_033111580.1 hypothetical protein -
BJD21_RS09435 2156585..2156935 + 351 WP_013316250.1 hypothetical protein -
BJD21_RS09445 2157838..2158581 + 744 WP_022632053.1 hypothetical protein -
BJD21_RS09450 2158640..2158858 + 219 WP_022632052.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
BJD21_RS09455 2158861..2159166 + 306 WP_022632051.1 type II toxin-antitoxin system toxin CcdB Toxin
BJD21_RS09460 2159656..2161596 - 1941 WP_022632050.1 hypothetical protein -
BJD21_RS09465 2161584..2162156 - 573 WP_022632049.1 hypothetical protein -
BJD21_RS09470 2162160..2163431 - 1272 WP_022632048.1 hypothetical protein -
BJD21_RS09475 2163547..2163944 - 398 Protein_1845 DUF3577 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2154698..2165023 10325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11779.68 Da        Isoelectric Point: 4.8837

>T66801 WP_022632051.1 NZ_CP017453:2158861-2159166 [Dickeya solani D s0432-1]
MQFIVYEYKRASHYKMFVDVQSDIVETPKRRMVIPLIEAHHLSEKVNKTLFPKIRIDGEDYRLMTTELSSVPVEVMGEVI
ADLGDYADEIKDAINLMFWGI

Download         Length: 306 bp

>T66801 NZ_CP017453:2158861-2159166 [Dickeya solani D s0432-1]
ATGCAATTCATTGTTTATGAATACAAACGAGCCAGTCACTACAAAATGTTTGTCGATGTGCAGAGTGATATCGTCGAGAC
ACCCAAGCGGCGCATGGTCATTCCGCTTATCGAAGCACACCACCTGTCTGAGAAAGTGAATAAGACGTTGTTCCCTAAGA
TCCGCATCGACGGCGAAGATTATCGGCTGATGACGACTGAACTATCGAGCGTACCTGTTGAAGTCATGGGTGAAGTGATT
GCGGATCTTGGCGACTACGCGGATGAGATTAAGGATGCTATTAATCTTATGTTTTGGGGGATTTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8109.02 Da        Isoelectric Point: 5.8316

>AT66801 WP_022632052.1 NZ_CP017453:2158640-2158858 [Dickeya solani D s0432-1]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDAIGKEARRIKAEEWKKENSEGMEEVARFIAQNGSFADENRNW

Download         Length: 219 bp

>AT66801 NZ_CP017453:2158640-2158858 [Dickeya solani D s0432-1]
ATGAAACACCGCGTCAGTGTTACCGTAGACAAAGACAACTATCAGGTTCTGAGTGCTGCCGGAGTCAACATTTCTGGGCT
GGTGAACGATGCCATTGGCAAAGAAGCCCGCCGTATCAAGGCTGAGGAGTGGAAGAAAGAAAACAGTGAGGGGATGGAGG
AAGTCGCCCGATTTATCGCGCAGAATGGCTCCTTTGCGGATGAAAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W1W4

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W1V7

References