66797

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 989238..989855 Replicon chromosome
Accession NZ_CP017453
Organism Dickeya solani D s0432-1

Toxin (Protein)


Gene name hicA Uniprot ID C6CDL0
Locus tag BJD21_RS04340 Protein ID WP_012764944.1
Coordinates 989238..989417 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2K8W4Y6
Locus tag BJD21_RS04345 Protein ID WP_022633005.1
Coordinates 989445..989855 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJD21_RS04325 987163..988218 + 1056 WP_022633006.1 MBL fold metallo-hydrolase -
BJD21_RS04335 988554..988916 - 363 WP_071598627.1 hypothetical protein -
BJD21_RS04340 989238..989417 + 180 WP_012764944.1 type II toxin-antitoxin system HicA family toxin Toxin
BJD21_RS04345 989445..989855 + 411 WP_022633005.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BJD21_RS04350 989858..990523 - 666 WP_022633004.1 RraA family protein -
BJD21_RS04355 990520..991365 - 846 WP_023637730.1 ABC transporter ATP-binding protein -
BJD21_RS04360 991377..992426 - 1050 WP_022633002.1 iron ABC transporter permease -
BJD21_RS04365 992419..993441 - 1023 WP_022633001.1 iron ABC transporter permease -
BJD21_RS04370 993438..994355 - 918 WP_023637727.1 iron-siderophore ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6530.61 Da        Isoelectric Point: 10.7838

>T66797 WP_012764944.1 NZ_CP017453:989238-989417 [Dickeya solani D s0432-1]
MDSRTLIAEIKADGWELVRVNGSHHHFTHPTKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Download         Length: 180 bp

>T66797 NZ_CP017453:989238-989417 [Dickeya solani D s0432-1]
ATGGACAGCAGGACGCTAATAGCAGAAATCAAGGCCGATGGATGGGAACTGGTAAGGGTTAACGGCAGTCATCACCATTT
TACCCACCCAACCAAACCGGGATTAGTGACCATCCCACACCCGAAGAAGGATTTACCGATAGGTACGGTAAAAAGCATCA
GGAAACAAGCGGGAATATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14499.48 Da        Isoelectric Point: 4.3391

>AT66797 WP_022633005.1 NZ_CP017453:989445-989855 [Dickeya solani D s0432-1]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDEAIANAKDAITGHIELLIEMGQDIPAVSSVGTLAKAPEYTGYTWAV
VDIDVTRLMGGAEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSIR

Download         Length: 411 bp

>AT66797 NZ_CP017453:989445-989855 [Dickeya solani D s0432-1]
ATGTTTTATCCCATTGCAATTGAAGCAGGCGACGATACTCATGCCTACGGCGTGACAGTGCCGGATCTGCCGGGCTGTTT
CTCCGCAGGTGATACGCTTGATGAGGCCATCGCCAATGCCAAAGACGCGATCACCGGCCATATCGAGCTGCTGATCGAGA
TGGGTCAGGATATTCCTGCTGTGTCATCAGTCGGAACGCTGGCGAAAGCACCGGAGTACACCGGTTACACCTGGGCTGTT
GTTGATATCGATGTCACCCGGCTGATGGGTGGGGCAGAGAAAATTAATGTCACGTTGCCGAAATCGCTGATTGACCGTAT
TGACCGTTGCGTAGCGAGTAACCCGGAATTTAAGAGCCGCTCAGGGTTCCTTGCTCAGGCAGCGTTAGAGCGGATTTCAT
CCATTCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W4W9

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W4Y6

References