66786

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 39931..40526 Replicon chromosome
Accession NZ_CP017453
Organism Dickeya solani D s0432-1

Toxin (Protein)


Gene name doc Uniprot ID E0SEA8
Locus tag BJD21_RS00175 Protein ID WP_013318177.1
Coordinates 40149..40526 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2K8VUJ6
Locus tag BJD21_RS00170 Protein ID WP_022633800.1
Coordinates 39931..40152 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJD21_RS00150 36332..37051 + 720 WP_022633804.1 nitrate reductase molybdenum cofactor assembly chaperone -
BJD21_RS00155 37051..37728 + 678 WP_022633803.1 respiratory nitrate reductase subunit gamma -
BJD21_RS00160 37800..38360 - 561 WP_026594485.1 NUDIX domain-containing protein -
BJD21_RS00165 38642..39790 + 1149 WP_022633801.1 L-threonine dehydrogenase -
BJD21_RS00170 39931..40152 + 222 WP_022633800.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BJD21_RS00175 40149..40526 + 378 WP_013318177.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
BJD21_RS00180 41164..42342 + 1179 WP_022633799.1 hypothetical protein -
BJD21_RS00185 42332..44098 + 1767 WP_022633798.1 ATP-binding protein -
BJD21_RS00190 44180..44362 - 183 WP_072142890.1 hypothetical protein -
BJD21_RS00195 44594..44860 - 267 WP_022633797.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14320.39 Da        Isoelectric Point: 4.9309

>T66786 WP_013318177.1 NZ_CP017453:40149-40526 [Dickeya solani D s0432-1]
MKWVSAQDVIDFHDRILQVLPGVVGMADPGRAEELIYRVQNRLYYEGVTELFELAATYWVTIARGHIFNDGNKRTAFFVT
MTFLRRNGILIVDNDNSLEELTIKAATGECLVSELAEQLRQRVEK

Download         Length: 378 bp

>T66786 NZ_CP017453:40149-40526 [Dickeya solani D s0432-1]
ATGAAATGGGTGAGTGCGCAGGACGTCATTGACTTCCATGATCGTATTTTGCAGGTGTTGCCTGGTGTGGTGGGTATGGC
TGATCCGGGTCGGGCTGAGGAGTTGATTTATCGAGTACAAAACCGTCTTTATTATGAAGGTGTGACCGAACTGTTTGAGT
TGGCGGCGACGTATTGGGTAACTATTGCTCGTGGTCATATTTTTAATGATGGCAATAAACGCACTGCTTTTTTTGTTACC
ATGACATTTTTGCGCCGCAATGGCATATTGATTGTCGATAACGATAATTCGCTGGAAGAACTCACCATTAAGGCGGCAAC
CGGAGAATGCCTGGTGTCGGAACTCGCCGAACAATTAAGACAACGGGTGGAAAAATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8207.33 Da        Isoelectric Point: 7.2021

>AT66786 WP_022633800.1 NZ_CP017453:39931-40152 [Dickeya solani D s0432-1]
MKTYTITEARQNIATVIDTAASGEPVEIKRRDGTSAVLIPKAEFEAYQKARLDAEFDFIMQRHGHTIKALADR

Download         Length: 222 bp

>AT66786 NZ_CP017453:39931-40152 [Dickeya solani D s0432-1]
ATGAAGACTTATACCATTACTGAAGCCCGGCAAAATATTGCGACAGTCATTGATACGGCGGCCAGCGGTGAGCCGGTAGA
GATTAAGCGTCGGGATGGCACCTCGGCTGTACTCATCCCCAAAGCAGAGTTTGAGGCTTATCAGAAAGCCAGATTAGACG
CTGAATTCGATTTCATCATGCAGCGCCACGGACACACAATCAAAGCGCTCGCCGACAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E0SEA8

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8VUJ6

References