Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | pemIK/PRK09812-MazE |
Location | 4011992..4012582 | Replicon | chromosome |
Accession | NZ_CP017450 | ||
Organism | Klebsiella sp. LTGPAF-6F |
Toxin (Protein)
Gene name | pemK | Uniprot ID | A0A1D8JW90 |
Locus tag | BJF97_RS18750 | Protein ID | WP_032693748.1 |
Coordinates | 4011992..4012324 (-) | Length | 111 a.a. |
Antitoxin (Protein)
Gene name | pemI | Uniprot ID | J6I3K7 |
Locus tag | BJF97_RS18755 | Protein ID | WP_004852307.1 |
Coordinates | 4012325..4012582 (-) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BJF97_RS18725 | 4007404..4007661 | + | 258 | WP_014229908.1 | histidine kinase | - |
BJF97_RS18730 | 4007794..4009248 | + | 1455 | WP_014229909.1 | AMP nucleosidase | - |
BJF97_RS18740 | 4010212..4011669 | - | 1458 | WP_014229916.1 | EmmdR/YeeO family multidrug/toxin efflux MATE transporter | - |
BJF97_RS18750 | 4011992..4012324 | - | 333 | WP_032693748.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
BJF97_RS18755 | 4012325..4012582 | - | 258 | WP_004852307.1 | antitoxin | Antitoxin |
BJF97_RS18760 | 4012843..4013036 | - | 194 | Protein_3699 | helix-turn-helix domain-containing protein | - |
BJF97_RS18765 | 4013033..4013506 | - | 474 | WP_050595132.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 11752.67 Da Isoelectric Point: 10.4751
>T66776 WP_032693748.1 NZ_CP017450:c4012324-4011992 [Klebsiella sp. LTGPAF-6F]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLARLPVVVPITSGGKFARTAGFTVSLEGAGTKTTGVIRCDQPRTI
DMVARNGKRLESIPDAVVNEVLARLDAILS
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLARLPVVVPITSGGKFARTAGFTVSLEGAGTKTTGVIRCDQPRTI
DMVARNGKRLESIPDAVVNEVLARLDAILS
Download Length: 333 bp
>T66776 NZ_CP017450:c4012324-4011992 [Klebsiella sp. LTGPAF-6F]
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTGGATCCGATTGCAGGCCACGAGCAAAGCGGAAAACGTCCGGTGCTTAT
CGTATCGAAGGCATCGTTTAACAAGCTGGCCCGGTTACCCGTTGTTGTTCCCATCACCAGCGGTGGAAAATTTGCTCGCA
CGGCAGGTTTCACCGTTTCACTGGAAGGGGCAGGGACAAAAACAACGGGCGTTATTCGCTGCGACCAGCCCAGAACCATT
GATATGGTTGCCCGGAACGGCAAGCGGCTGGAAAGCATACCAGACGCTGTGGTAAATGAAGTGCTTGCCAGGCTGGATGC
AATTTTAAGTTAA
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTGGATCCGATTGCAGGCCACGAGCAAAGCGGAAAACGTCCGGTGCTTAT
CGTATCGAAGGCATCGTTTAACAAGCTGGCCCGGTTACCCGTTGTTGTTCCCATCACCAGCGGTGGAAAATTTGCTCGCA
CGGCAGGTTTCACCGTTTCACTGGAAGGGGCAGGGACAAAAACAACGGGCGTTATTCGCTGCGACCAGCCCAGAACCATT
GATATGGTTGCCCGGAACGGCAAGCGGCTGGAAAGCATACCAGACGCTGTGGTAAATGAAGTGCTTGCCAGGCTGGATGC
AATTTTAAGTTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9422.88 Da Isoelectric Point: 4.4607
>AT66776 WP_004852307.1 NZ_CP017450:c4012582-4012325 [Klebsiella sp. LTGPAF-6F]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTINNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTINNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL
Download Length: 258 bp
>AT66776 NZ_CP017450:c4012582-4012325 [Klebsiella sp. LTGPAF-6F]
ATGTATACCACTCGCCTGAAAAAGGTCGGCGGCTCCATCATGTTGGCGGTTCCTCCCGCCGTGCTCAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTCGGCATGACCATTAATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCTCATTATTCTC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATAGGGAATGGATTGATGCTCCTGCGGTG
GGCAAGGAGATCCTGTAG
ATGTATACCACTCGCCTGAAAAAGGTCGGCGGCTCCATCATGTTGGCGGTTCCTCCCGCCGTGCTCAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTCGGCATGACCATTAATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCTCATTATTCTC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATAGGGAATGGATTGATGCTCCTGCGGTG
GGCAAGGAGATCCTGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1D8JW90 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3HDW8 |