Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | shpAB/BrnT-BrnA |
Location | 860963..861539 | Replicon | chromosome |
Accession | NZ_CP017450 | ||
Organism | Klebsiella sp. LTGPAF-6F |
Toxin (Protein)
Gene name | shpA | Uniprot ID | A0A1D8JNH2 |
Locus tag | BJF97_RS04095 | Protein ID | WP_042933975.1 |
Coordinates | 860963..861250 (+) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | shpB | Uniprot ID | A0A1D8JNF7 |
Locus tag | BJF97_RS04100 | Protein ID | WP_025108476.1 |
Coordinates | 861237..861539 (+) | Length | 101 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BJF97_RS04065 | 856304..856822 | - | 519 | WP_004098240.1 | hypothetical protein | - |
BJF97_RS04070 | 856819..857619 | - | 801 | WP_032693034.1 | winged helix-turn-helix domain-containing protein | - |
BJF97_RS04075 | 857765..858349 | - | 585 | WP_004098242.1 | TetR/AcrR family transcriptional regulator | - |
BJF97_RS04080 | 858497..859279 | - | 783 | WP_032693033.1 | NAD(P)H-dependent oxidoreductase | - |
BJF97_RS04085 | 859367..860275 | + | 909 | WP_032693031.1 | LysR family transcriptional regulator | - |
BJF97_RS04090 | 860269..860712 | + | 444 | WP_032693030.1 | FosA family fosfomycin resistance glutathione transferase | - |
BJF97_RS04095 | 860963..861250 | + | 288 | WP_042933975.1 | BrnT family toxin | Toxin |
BJF97_RS04100 | 861237..861539 | + | 303 | WP_025108476.1 | BrnA antitoxin family protein | Antitoxin |
BJF97_RS04105 | 861660..863003 | - | 1344 | WP_070082846.1 | APC family permease | - |
BJF97_RS04110 | 863000..863911 | - | 912 | WP_032693024.1 | acetamidase/formamidase family protein | - |
BJF97_RS04115 | 864363..864698 | - | 336 | WP_014227760.1 | endoribonuclease SymE | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11239.69 Da Isoelectric Point: 8.5899
>T66765 WP_042933975.1 NZ_CP017450:860963-861250 [Klebsiella sp. LTGPAF-6F]
MPMEFEWDANKARSNLRKHGIRFEEAVLVFDDPRHLSRQDRYENGEYRWQTIGLVHGVIVIMVAHSVRFESGTEVIRIIS
ARKADSKERNRYEHG
MPMEFEWDANKARSNLRKHGIRFEEAVLVFDDPRHLSRQDRYENGEYRWQTIGLVHGVIVIMVAHSVRFESGTEVIRIIS
ARKADSKERNRYEHG
Download Length: 288 bp
>T66765 NZ_CP017450:860963-861250 [Klebsiella sp. LTGPAF-6F]
ATGCCAATGGAGTTTGAATGGGATGCGAACAAGGCAAGAAGTAATCTAAGAAAACATGGAATCCGGTTTGAAGAAGCGGT
GCTCGTCTTTGACGATCCCCGGCATCTTTCCCGACAGGATCGTTATGAGAATGGTGAATATCGCTGGCAAACTATCGGTC
TCGTTCATGGGGTCATTGTTATCATGGTTGCGCATTCGGTCCGTTTTGAAAGTGGAACAGAGGTCATTCGTATTATCAGC
GCCCGGAAGGCGGACAGCAAAGAGAGAAATCGTTATGAACATGGTTAA
ATGCCAATGGAGTTTGAATGGGATGCGAACAAGGCAAGAAGTAATCTAAGAAAACATGGAATCCGGTTTGAAGAAGCGGT
GCTCGTCTTTGACGATCCCCGGCATCTTTCCCGACAGGATCGTTATGAGAATGGTGAATATCGCTGGCAAACTATCGGTC
TCGTTCATGGGGTCATTGTTATCATGGTTGCGCATTCGGTCCGTTTTGAAAGTGGAACAGAGGTCATTCGTATTATCAGC
GCCCGGAAGGCGGACAGCAAAGAGAGAAATCGTTATGAACATGGTTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11563.17 Da Isoelectric Point: 9.7962
>AT66765 WP_025108476.1 NZ_CP017450:861237-861539 [Klebsiella sp. LTGPAF-6F]
MNMVKHKRDNPDTLTAKRADELKALANKTDDEIDYSDIPATDDAQWSDAVRGKFYRPLKTQASVRIDADIMEWLKRPGKG
YQTRLNAILREAMIRDLNKK
MNMVKHKRDNPDTLTAKRADELKALANKTDDEIDYSDIPATDDAQWSDAVRGKFYRPLKTQASVRIDADIMEWLKRPGKG
YQTRLNAILREAMIRDLNKK
Download Length: 303 bp
>AT66765 NZ_CP017450:861237-861539 [Klebsiella sp. LTGPAF-6F]
ATGAACATGGTTAAACATAAACGTGACAATCCGGATACGCTTACGGCTAAGCGAGCCGATGAGCTTAAAGCGCTGGCCAA
CAAAACGGATGATGAAATCGATTATAGCGATATTCCCGCCACAGACGACGCACAGTGGTCAGATGCCGTACGCGGTAAAT
TTTACCGACCGCTAAAAACTCAGGCTTCTGTCCGTATTGATGCCGATATTATGGAGTGGCTTAAACGTCCCGGGAAAGGT
TATCAAACGCGACTGAATGCGATCTTAAGAGAAGCGATGATTCGCGATCTTAACAAGAAATAG
ATGAACATGGTTAAACATAAACGTGACAATCCGGATACGCTTACGGCTAAGCGAGCCGATGAGCTTAAAGCGCTGGCCAA
CAAAACGGATGATGAAATCGATTATAGCGATATTCCCGCCACAGACGACGCACAGTGGTCAGATGCCGTACGCGGTAAAT
TTTACCGACCGCTAAAAACTCAGGCTTCTGTCCGTATTGATGCCGATATTATGGAGTGGCTTAAACGTCCCGGGAAAGGT
TATCAAACGCGACTGAATGCGATCTTAAGAGAAGCGATGATTCGCGATCTTAACAAGAAATAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1D8JNH2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1D8JNF7 |