Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3529625..3530103 Replicon chromosome
Accession NZ_CP017444
Organism Escherichia coli O157:H7 strain 8368

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag A4C39_RS18670 Protein ID WP_001303876.1
Coordinates 3529816..3530103 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag A4C39_RS18665 Protein ID WP_000536233.1
Coordinates 3529625..3529816 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4C39_RS18630 3525029..3525799 - 771 WP_000450992.1 DUF1627 domain-containing protein -
A4C39_RS18635 3525821..3526567 - 747 WP_000788751.1 ATP-binding protein -
A4C39_RS18640 3526574..3527665 - 1092 WP_001205823.1 hypothetical protein -
A4C39_RS29945 3527744..3528199 + 456 WP_000273724.1 hypothetical protein -
A4C39_RS18650 3528406..3528831 - 426 WP_000693855.1 Rha family transcriptional regulator -
A4C39_RS18655 3528815..3529087 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
A4C39_RS18660 3529196..3529597 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
A4C39_RS18665 3529625..3529816 + 192 WP_000536233.1 hypothetical protein Antitoxin
A4C39_RS18670 3529816..3530103 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A4C39_RS18675 3530381..3530536 + 156 WP_000379575.1 DUF1391 family protein -
A4C39_RS18680 3530678..3531067 + 390 WP_000394511.1 hypothetical protein -
A4C39_RS18685 3531254..3531439 - 186 WP_001133046.1 hypothetical protein -
A4C39_RS18695 3532013..3532201 + 189 WP_000413705.1 cell division inhibition protein DicB -
A4C39_RS18700 3532198..3532389 + 192 WP_001098307.1 DUF1482 family protein -
A4C39_RS18705 3532483..3534954 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T66716 WP_001303876.1 NZ_CP017444:3529816-3530103 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T66716 NZ_CP017444:3529816-3530103 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT66716 WP_000536233.1 NZ_CP017444:3529625-3529816 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT66716 NZ_CP017444:3529625-3529816 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References