Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3496335..3496813 Replicon chromosome
Accession NZ_CP017442
Organism Escherichia coli O157:H7 strain 4276

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag A4C51_RS18445 Protein ID WP_001303876.1
Coordinates 3496526..3496813 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag A4C51_RS18440 Protein ID WP_000536233.1
Coordinates 3496335..3496526 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4C51_RS18405 3491739..3492509 - 771 WP_000450992.1 DUF1627 domain-containing protein -
A4C51_RS18410 3492531..3493277 - 747 WP_000788751.1 ATP-binding protein -
A4C51_RS18415 3493284..3494375 - 1092 WP_001205823.1 hypothetical protein -
A4C51_RS29725 3494454..3494909 + 456 WP_000273724.1 hypothetical protein -
A4C51_RS18425 3495116..3495541 - 426 WP_000693855.1 Rha family transcriptional regulator -
A4C51_RS18430 3495525..3495797 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
A4C51_RS18435 3495906..3496307 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
A4C51_RS18440 3496335..3496526 + 192 WP_000536233.1 hypothetical protein Antitoxin
A4C51_RS18445 3496526..3496813 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A4C51_RS18450 3497091..3497246 + 156 WP_000379575.1 DUF1391 family protein -
A4C51_RS18455 3497388..3497711 + 324 WP_001458970.1 hypothetical protein -
A4C51_RS18460 3497964..3498149 - 186 WP_001133046.1 hypothetical protein -
A4C51_RS18470 3498723..3498911 + 189 WP_000413705.1 cell division inhibition protein DicB -
A4C51_RS18475 3498908..3499099 + 192 WP_001098307.1 DUF1482 family protein -
A4C51_RS18480 3499193..3501664 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T66685 WP_001303876.1 NZ_CP017442:3496526-3496813 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T66685 NZ_CP017442:3496526-3496813 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT66685 WP_000536233.1 NZ_CP017442:3496335-3496526 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT66685 NZ_CP017442:3496335-3496526 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References