Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3498670..3499148 Replicon chromosome
Accession NZ_CP017436
Organism Escherichia coli O157:H7 strain 2149

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag A4C44_RS18470 Protein ID WP_001303876.1
Coordinates 3498861..3499148 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag A4C44_RS18465 Protein ID WP_000536233.1
Coordinates 3498670..3498861 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4C44_RS18430 3494074..3494844 - 771 WP_000450992.1 DUF1627 domain-containing protein -
A4C44_RS18435 3494866..3495612 - 747 WP_000788751.1 ATP-binding protein -
A4C44_RS18440 3495619..3496710 - 1092 WP_001205823.1 hypothetical protein -
A4C44_RS29735 3496789..3497244 + 456 WP_000273724.1 hypothetical protein -
A4C44_RS18450 3497451..3497876 - 426 WP_000693855.1 Rha family transcriptional regulator -
A4C44_RS18455 3497860..3498132 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
A4C44_RS18460 3498241..3498642 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
A4C44_RS18465 3498670..3498861 + 192 WP_000536233.1 hypothetical protein Antitoxin
A4C44_RS18470 3498861..3499148 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A4C44_RS18475 3499426..3499581 + 156 WP_000379575.1 DUF1391 family protein -
A4C44_RS18480 3499723..3500046 + 324 WP_001458970.1 hypothetical protein -
A4C44_RS18485 3500299..3500484 - 186 WP_001133046.1 hypothetical protein -
A4C44_RS18495 3501058..3501246 + 189 WP_000413705.1 cell division inhibition protein DicB -
A4C44_RS18500 3501243..3501434 + 192 WP_001098307.1 DUF1482 family protein -
A4C44_RS18505 3501528..3503999 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T66582 WP_001303876.1 NZ_CP017436:3498861-3499148 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T66582 NZ_CP017436:3498861-3499148 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT66582 WP_000536233.1 NZ_CP017436:3498670-3498861 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT66582 NZ_CP017436:3498670-3498861 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References