Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1668505..1669324 Replicon chromosome
Accession NZ_CP017430
Organism Staphylococcus simulans strain MR4

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag BI283_RS08000 Protein ID WP_106421061.1
Coordinates 1668851..1669324 (+) Length 158 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag BI283_RS07995 Protein ID WP_105996454.1
Coordinates 1668505..1668837 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BI283_RS07940 1663738..1664184 - 447 WP_106421052.1 single-stranded DNA-binding protein -
BI283_RS07945 1664184..1664855 - 672 WP_106421053.1 ERF family protein -
BI283_RS07950 1664818..1665072 - 255 WP_106421054.1 DUF2483 family protein -
BI283_RS07955 1665065..1665289 - 225 WP_106421055.1 hypothetical protein -
BI283_RS07960 1665389..1665604 - 216 WP_106421056.1 hypothetical protein -
BI283_RS07965 1665617..1665919 - 303 WP_002480770.1 DUF771 domain-containing protein -
BI283_RS07970 1666034..1666357 + 324 WP_106421057.1 hypothetical protein -
BI283_RS14030 1666346..1666504 - 159 WP_159079669.1 hypothetical protein -
BI283_RS07975 1666551..1666778 - 228 WP_106421058.1 hypothetical protein -
BI283_RS07980 1666779..1667552 - 774 WP_106421059.1 phage antirepressor KilAC domain-containing protein -
BI283_RS07985 1667668..1667904 + 237 WP_105976070.1 hypothetical protein -
BI283_RS14035 1667897..1668058 - 162 WP_182477690.1 hypothetical protein -
BI283_RS07990 1668073..1668312 - 240 WP_106421060.1 helix-turn-helix domain-containing protein -
BI283_RS07995 1668505..1668837 + 333 WP_105996454.1 helix-turn-helix domain-containing protein Antitoxin
BI283_RS08000 1668851..1669324 + 474 WP_106421061.1 ImmA/IrrE family metallo-endopeptidase Toxin
BI283_RS08005 1669311..1669952 + 642 WP_105976065.1 DUF4352 domain-containing protein -
BI283_RS13930 1670131..1670271 + 141 WP_158257428.1 hypothetical protein -
BI283_RS08010 1670366..1670881 + 516 WP_106421062.1 hypothetical protein -
BI283_RS08015 1670883..1671191 + 309 WP_106421063.1 hypothetical protein -
BI283_RS08020 1671256..1672284 + 1029 WP_106421064.1 site-specific integrase -
BI283_RS08025 1672296..1672475 - 180 WP_180363558.1 RNA chaperone Hfq -
BI283_RS08030 1672472..1673434 - 963 WP_106421065.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1593405..1672284 78879


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(31-118)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-65)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 18576.85 Da        Isoelectric Point: 6.2286

>T66521 WP_106421061.1 NZ_CP017430:1668851-1669324 [Staphylococcus simulans]
MGVYEDLCIANDWVEIEETDRLPSFQPGFYRNGKIYIKSSLSEIRKAEVLYEELAHHKLTYGNILDESSFNNRKFENYAR
RHGYENSISLNKIIDAYKYGVSSLYEFAEYVQLSEEHVYTVLQHYKNKFGLSTCHNGYLIRFEPLQVFKYKKLNEGD

Download         Length: 474 bp

>T66521 NZ_CP017430:1668851-1669324 [Staphylococcus simulans]
ATGGGAGTTTACGAAGATTTATGTATCGCTAACGATTGGGTTGAGATTGAGGAGACTGATCGTTTACCTAGTTTCCAACC
AGGGTTCTACAGAAATGGAAAAATCTATATTAAAAGCAGTCTTTCCGAAATACGAAAAGCTGAAGTTCTCTATGAAGAAT
TAGCTCACCATAAACTTACATACGGAAATATACTTGATGAATCAAGTTTCAATAACCGTAAATTCGAAAATTACGCACGA
AGACATGGTTATGAAAATTCTATATCTTTGAACAAGATTATAGACGCATATAAATACGGAGTAAGTAGCTTATATGAATT
TGCTGAATATGTTCAATTAAGCGAAGAACACGTATATACAGTGTTACAGCATTACAAAAATAAATTCGGTTTATCAACTT
GCCATAACGGCTATCTTATTCGATTTGAGCCATTGCAGGTTTTTAAATATAAAAAATTAAATGAAGGAGATTAG

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12869.51 Da        Isoelectric Point: 4.7176

>AT66521 WP_105996454.1 NZ_CP017430:1668505-1668837 [Staphylococcus simulans]
MRTNDEIITIIKTTLKEQNMSLSELARRVGMAKSAVSRYLNLTREFPLNRAEDFAKALHISTEYLLGFTESEQKEQEQDT
MAAHFDKEGLTEEEIEEVNKFIEWVKNRDK

Download         Length: 333 bp

>AT66521 NZ_CP017430:1668505-1668837 [Staphylococcus simulans]
ATGAGAACAAATGATGAAATAATCACAATAATAAAAACAACGTTAAAAGAACAAAATATGTCGCTTAGTGAATTAGCTCG
TCGTGTAGGAATGGCTAAATCAGCTGTATCGCGTTATTTAAACTTAACTAGAGAGTTTCCATTGAACCGTGCGGAAGATT
TTGCAAAAGCACTTCATATTAGTACAGAATATTTACTTGGTTTTACAGAAAGTGAACAAAAAGAGCAAGAACAAGACACT
ATGGCCGCTCATTTTGACAAAGAAGGTCTAACAGAAGAGGAAATTGAAGAAGTTAATAAGTTTATTGAATGGGTTAAGAA
TAGAGATAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References