Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 969893..970407 Replicon chromosome
Accession NZ_CP017430
Organism Staphylococcus simulans strain MR4

Toxin (Protein)


Gene name TsdT Uniprot ID A0A133QQ97
Locus tag BI283_RS04390 Protein ID WP_002481764.1
Coordinates 970201..970407 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A133QQA1
Locus tag BI283_RS04385 Protein ID WP_002481765.1
Coordinates 969893..970186 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BI283_RS04360 965288..965926 + 639 WP_002481770.1 thiamine phosphate synthase -
BI283_RS04365 966015..966884 + 870 WP_002481769.1 membrane protein insertase YidC -
BI283_RS04370 967010..967522 + 513 WP_002481768.1 GNAT family N-acetyltransferase -
BI283_RS04375 967579..968229 - 651 WP_060804054.1 HD domain-containing protein -
BI283_RS04380 968253..969734 - 1482 WP_106420978.1 cardiolipin synthase -
BI283_RS04385 969893..970186 + 294 WP_002481765.1 copper-sensing transcriptional repressor CsoR Antitoxin
BI283_RS04390 970201..970407 + 207 WP_002481764.1 heavy-metal-associated domain-containing protein Toxin
BI283_RS04395 970426..970632 + 207 WP_002481763.1 copper ion binding protein -
BI283_RS04400 970725..972893 + 2169 WP_105967035.1 heavy metal translocating P-type ATPase -
BI283_RS14000 972999..973139 + 141 WP_023016106.1 hypothetical protein -
BI283_RS04405 973199..974407 - 1209 WP_002481760.1 rod shape-determining protein RodA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(24-65)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7861.82 Da        Isoelectric Point: 4.2670

>T66519 WP_002481764.1 NZ_CP017430:970201-970407 [Staphylococcus simulans]
MHSSVIQISGMETEEQQHILQEHLQQMIGMSEVQVDLKSQEVKASYQTPISLNNLEKEIYDQGYQILN

Download         Length: 207 bp

>T66519 NZ_CP017430:970201-970407 [Staphylococcus simulans]
ATGCATAGTAGTGTGATTCAAATCAGTGGTATGGAAACTGAAGAACAACAGCATATTTTGCAAGAACATTTGCAGCAAAT
GATTGGTATGTCAGAAGTGCAAGTGGATCTGAAATCACAAGAAGTGAAAGCGAGTTACCAGACACCAATCAGTTTAAACA
ATTTGGAAAAAGAAATTTATGATCAAGGTTACCAAATATTAAATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11033.69 Da        Isoelectric Point: 6.9688

>AT66519 WP_002481765.1 NZ_CP017430:969893-970186 [Staphylococcus simulans]
MTQEERAHHSEKIKSNLKARLNRIEGQVRAINRMIDEDVYCDDVLTQIRATRSALNSVAVKLLDHHMKGCILHKAEDGQA
EAAMEELLVTVQKLIKD

Download         Length: 294 bp

>AT66519 NZ_CP017430:969893-970186 [Staphylococcus simulans]
ATGACGCAAGAAGAACGCGCACATCATTCAGAAAAAATAAAATCTAACCTTAAAGCACGACTGAATCGTATAGAAGGACA
AGTCAGAGCGATTAATCGCATGATAGATGAAGATGTTTATTGTGATGATGTTTTAACACAAATCAGAGCGACACGTTCAG
CTTTGAATAGTGTTGCTGTAAAATTGCTGGATCATCATATGAAAGGCTGTATTTTGCATAAAGCTGAAGATGGACAAGCA
GAAGCTGCAATGGAAGAATTATTAGTTACCGTCCAAAAATTAATTAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133QQ97

Antitoxin

Source ID Structure
AlphaFold DB A0A133QQA1

References