Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1675787..1676606 Replicon chromosome
Accession NZ_CP017428
Organism Staphylococcus simulans strain MR3

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag BI282_RS08035 Protein ID WP_106421061.1
Coordinates 1676133..1676606 (+) Length 158 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag BI282_RS08030 Protein ID WP_105996454.1
Coordinates 1675787..1676119 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BI282_RS07975 1671020..1671466 - 447 WP_106421052.1 single-stranded DNA-binding protein -
BI282_RS07980 1671466..1672137 - 672 WP_106421053.1 ERF family protein -
BI282_RS07985 1672100..1672354 - 255 WP_106421054.1 DUF2483 family protein -
BI282_RS07990 1672347..1672571 - 225 WP_106421055.1 hypothetical protein -
BI282_RS07995 1672671..1672886 - 216 WP_106421056.1 hypothetical protein -
BI282_RS08000 1672899..1673201 - 303 WP_002480770.1 DUF771 domain-containing protein -
BI282_RS08005 1673316..1673639 + 324 WP_106421057.1 hypothetical protein -
BI282_RS13915 1673628..1673786 - 159 WP_159079669.1 hypothetical protein -
BI282_RS08010 1673833..1674060 - 228 WP_106421058.1 hypothetical protein -
BI282_RS08015 1674061..1674834 - 774 WP_106421059.1 phage antirepressor KilAC domain-containing protein -
BI282_RS08020 1674950..1675186 + 237 WP_105976070.1 hypothetical protein -
BI282_RS14010 1675179..1675340 - 162 WP_182477690.1 hypothetical protein -
BI282_RS08025 1675355..1675594 - 240 WP_106421060.1 helix-turn-helix domain-containing protein -
BI282_RS08030 1675787..1676119 + 333 WP_105996454.1 helix-turn-helix domain-containing protein Antitoxin
BI282_RS08035 1676133..1676606 + 474 WP_106421061.1 ImmA/IrrE family metallo-endopeptidase Toxin
BI282_RS08040 1676593..1677234 + 642 WP_105976065.1 DUF4352 domain-containing protein -
BI282_RS08045 1677648..1678163 + 516 WP_106421062.1 hypothetical protein -
BI282_RS08050 1678165..1678473 + 309 WP_106421063.1 hypothetical protein -
BI282_RS08055 1678538..1679566 + 1029 WP_106421064.1 site-specific integrase -
BI282_RS08060 1679578..1679757 - 180 WP_180363558.1 RNA chaperone Hfq -
BI282_RS08065 1679754..1680716 - 963 WP_106421065.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1640109..1679566 39457


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(31-118)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-65)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 18576.85 Da        Isoelectric Point: 6.2286

>T66517 WP_106421061.1 NZ_CP017428:1676133-1676606 [Staphylococcus simulans]
MGVYEDLCIANDWVEIEETDRLPSFQPGFYRNGKIYIKSSLSEIRKAEVLYEELAHHKLTYGNILDESSFNNRKFENYAR
RHGYENSISLNKIIDAYKYGVSSLYEFAEYVQLSEEHVYTVLQHYKNKFGLSTCHNGYLIRFEPLQVFKYKKLNEGD

Download         Length: 474 bp

>T66517 NZ_CP017428:1676133-1676606 [Staphylococcus simulans]
ATGGGAGTTTACGAAGATTTATGTATCGCTAACGATTGGGTTGAGATTGAGGAGACTGATCGTTTACCTAGTTTCCAACC
AGGGTTCTACAGAAATGGAAAAATCTATATTAAAAGCAGTCTTTCCGAAATACGAAAAGCTGAAGTTCTCTATGAAGAAT
TAGCTCACCATAAACTTACATACGGAAATATACTTGATGAATCAAGTTTCAATAACCGTAAATTCGAAAATTACGCACGA
AGACATGGTTATGAAAATTCTATATCTTTGAACAAGATTATAGACGCATATAAATACGGAGTAAGTAGCTTATATGAATT
TGCTGAATATGTTCAATTAAGCGAAGAACACGTATATACAGTGTTACAGCATTACAAAAATAAATTCGGTTTATCAACTT
GCCATAACGGCTATCTTATTCGATTTGAGCCATTGCAGGTTTTTAAATATAAAAAATTAAATGAAGGAGATTAG

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12869.51 Da        Isoelectric Point: 4.7176

>AT66517 WP_105996454.1 NZ_CP017428:1675787-1676119 [Staphylococcus simulans]
MRTNDEIITIIKTTLKEQNMSLSELARRVGMAKSAVSRYLNLTREFPLNRAEDFAKALHISTEYLLGFTESEQKEQEQDT
MAAHFDKEGLTEEEIEEVNKFIEWVKNRDK

Download         Length: 333 bp

>AT66517 NZ_CP017428:1675787-1676119 [Staphylococcus simulans]
ATGAGAACAAATGATGAAATAATCACAATAATAAAAACAACGTTAAAAGAACAAAATATGTCGCTTAGTGAATTAGCTCG
TCGTGTAGGAATGGCTAAATCAGCTGTATCGCGTTATTTAAACTTAACTAGAGAGTTTCCATTGAACCGTGCGGAAGATT
TTGCAAAAGCACTTCATATTAGTACAGAATATTTACTTGGTTTTACAGAAAGTGAACAAAAAGAGCAAGAACAAGACACT
ATGGCCGCTCATTTTGACAAAGAAGGTCTAACAGAAGAGGAAATTGAAGAAGTTAATAAGTTTATTGAATGGGTTAAGAA
TAGAGATAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References