Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 4294896..4296579 Replicon chromosome
Accession NZ_CP017420
Organism Delftia tsuruhatensis strain CM13

Toxin (Protein)


Gene name doc Uniprot ID A0A1D8J415
Locus tag BI380_RS19945 Protein ID WP_046240585.1
Coordinates 4295725..4296579 (-) Length 285 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A072T3J4
Locus tag BI380_RS19940 Protein ID WP_016449819.1
Coordinates 4294896..4295702 (-) Length 269 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BI380_RS19915 4290642..4291412 - 771 WP_012202888.1 SDR family oxidoreductase -
BI380_RS33430 4291967..4292242 + 276 WP_074931722.1 hypothetical protein -
BI380_RS19920 4292506..4292853 + 348 WP_017406311.1 type II toxin-antitoxin system RelE/ParE family toxin -
BI380_RS19925 4292850..4293158 + 309 WP_016449816.1 XRE family transcriptional regulator -
BI380_RS19930 4293171..4293932 - 762 WP_070080719.1 5'-methylthioadenosine/adenosylhomocysteine nucleosidase -
BI380_RS19935 4294044..4294841 - 798 WP_046240587.1 aspartate dehydrogenase -
BI380_RS19940 4294896..4295702 - 807 WP_016449819.1 IclR family transcriptional regulator Antitoxin
BI380_RS19945 4295725..4296579 - 855 WP_046240585.1 alpha/beta fold hydrolase Toxin
BI380_RS19950 4296594..4297123 - 530 Protein_4071 cupin domain-containing protein -
BI380_RS19955 4297323..4298518 - 1196 Protein_4072 MFS transporter -
BI380_RS19960 4298541..4299425 - 885 WP_016449823.1 NAD(P)-dependent oxidoreductase -
BI380_RS19965 4299562..4300152 - 591 WP_013804518.1 TetR/AcrR family transcriptional regulator -
BI380_RS19970 4300234..4300725 - 492 WP_016449824.1 Lrp/AsnC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(43-270)

Antitoxin

Transcription regulator IclR, C-terminal

(137-255)


Sequences

Toxin        


Download         Length: 285 a.a.        Molecular weight: 29682.02 Da        Isoelectric Point: 7.8450

>T66510 WP_046240585.1 NZ_CP017420:c4296579-4295725 [Delftia tsuruhatensis]
MTAQTLQRMEQRLQAQFPEHLIALPGGAQVAWREAGDTTSDFAVVMLHGISSGAASWMDVALALAPRTRVLAWDASGYGR
STPLTPAAPTGADYARVLEQSLQALGVRRCLLVGHSLGALMGTPWAVQAGAGRVQQLVLISPAGGYGAPGMGEQQAKVRQ
GRLAALQEKGIEGLAAAIDQRLVSPAAPEPVRQWVRWNTARLHAAGYAQAVELLCGSDLGQAAGRLAMPVEVWVGEHDVV
TPPAACAAWAARLGARYVTLAAAGHASVVEQPADVAQRLATLLT

Download         Length: 855 bp

>T66510 NZ_CP017420:c4296579-4295725 [Delftia tsuruhatensis]
ATGACCGCGCAGACGCTGCAACGCATGGAGCAGCGCCTTCAGGCGCAGTTCCCCGAACACCTCATCGCCCTGCCCGGTGG
CGCCCAGGTCGCCTGGCGCGAGGCCGGCGACACGACCTCGGACTTTGCCGTGGTGATGCTGCACGGCATCAGCTCGGGCG
CCGCGTCCTGGATGGACGTGGCCCTGGCGCTGGCGCCGCGCACGCGTGTGCTGGCCTGGGACGCGTCCGGCTATGGCCGC
TCCACACCGCTGACACCCGCCGCGCCCACGGGCGCCGACTACGCCCGCGTGCTGGAGCAGTCGCTGCAGGCGCTGGGCGT
GCGCCGCTGCCTGCTGGTGGGCCACTCGCTGGGTGCGCTCATGGGCACGCCCTGGGCGGTGCAGGCCGGTGCCGGGCGCG
TGCAGCAACTGGTGCTGATCAGCCCCGCTGGCGGCTATGGCGCACCCGGCATGGGCGAGCAGCAGGCCAAGGTACGCCAG
GGCCGTCTTGCGGCCCTGCAGGAAAAAGGCATCGAAGGCCTGGCCGCCGCCATCGACCAGCGCCTGGTCTCGCCCGCCGC
GCCCGAGCCCGTGCGCCAATGGGTGCGCTGGAACACGGCGCGCCTGCATGCCGCAGGCTACGCCCAGGCCGTGGAGCTGC
TGTGCGGCAGCGACCTGGGGCAGGCGGCGGGGCGCCTTGCCATGCCGGTCGAGGTCTGGGTGGGAGAGCACGACGTGGTC
ACGCCGCCGGCTGCCTGCGCGGCCTGGGCCGCAAGACTGGGGGCGCGGTACGTTACGCTTGCGGCAGCCGGCCATGCCTC
TGTCGTCGAACAACCTGCGGATGTCGCACAGAGGCTGGCCACCCTGCTGACCTGA

Antitoxin


Download         Length: 269 a.a.        Molecular weight: 29047.08 Da        Isoelectric Point: 5.3408

>AT66510 WP_016449819.1 NZ_CP017420:c4295702-4294896 [Delftia tsuruhatensis]
MSDTSETLSNDNDRYTVPALERGLRLLACFTPSQPVWSAPDLARTLALPRSTVFRMLTTLEGMGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQSLCDRLGFTTNLALLDGTSVVYVARIAPAGAFQGAVRVGSRLPAHATVLGRALLQDMDA
DQLRALFGGSELPQFSESTPRSVEQLLQLLQQDHERGYAMGEGFYEPGVSSIAAPVRDAQGRIVAGLGMAVAFTEIAPGR
MADWVEQVRAAADELAGHLRTQHPGFLR

Download         Length: 807 bp

>AT66510 NZ_CP017420:c4295702-4294896 [Delftia tsuruhatensis]
ATGAGCGATACCTCCGAAACCCTCTCGAACGACAACGACCGCTACACCGTTCCCGCGCTGGAGCGCGGCCTGCGCCTGCT
GGCCTGCTTCACGCCTTCGCAGCCCGTGTGGAGCGCGCCCGACCTGGCGCGCACCCTGGCGCTGCCCCGGTCCACGGTGT
TCCGGATGCTGACGACGCTGGAGGGCATGGGGTATCTGCAACGCTCGGGCACCGAATACCGGCTGGGCCTGGCCGTGCTG
CGCCTGGGCTACGACTACCTGTCCACCCAGCCGCTGGCCCAGCTGGCCGAGCCCGTGCTGCAGTCGCTGTGCGACCGGCT
GGGCTTCACCACCAACCTGGCGCTGCTGGACGGCACCTCGGTGGTCTACGTGGCGCGCATCGCGCCGGCCGGCGCCTTCC
AGGGCGCCGTGCGCGTGGGCTCGCGGCTGCCGGCCCATGCCACCGTGCTGGGCCGGGCACTGCTGCAGGACATGGACGCG
GACCAGCTGCGCGCCCTGTTCGGCGGCAGCGAACTGCCCCAGTTCTCGGAAAGCACGCCGCGCAGCGTGGAACAGTTGCT
GCAGTTGCTGCAGCAGGACCATGAACGCGGCTACGCCATGGGCGAGGGCTTCTACGAGCCCGGCGTCTCCAGCATCGCCG
CGCCCGTGCGCGATGCGCAGGGGCGCATCGTGGCGGGCCTGGGCATGGCCGTGGCCTTCACCGAAATCGCTCCCGGCCGC
ATGGCCGACTGGGTGGAGCAGGTGCGTGCCGCCGCCGATGAGCTGGCCGGCCACCTGCGCACCCAGCATCCCGGTTTTCT
GCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D8J415

Antitoxin

Source ID Structure
AlphaFold DB A0A072T3J4

References