Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 167505..168214 Replicon chromosome
Accession NZ_CP017420
Organism Delftia tsuruhatensis strain CM13

Toxin (Protein)


Gene name vapC Uniprot ID A0A1D8IU07
Locus tag BI380_RS00895 Protein ID WP_046240622.1
Coordinates 167505..167951 (-) Length 149 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1D8IU58
Locus tag BI380_RS00900 Protein ID WP_016453264.1
Coordinates 167948..168214 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BI380_RS00875 162811..163860 + 1050 WP_016448246.1 efflux RND transporter periplasmic adaptor subunit -
BI380_RS00880 163874..165088 + 1215 WP_070080304.1 ABC transporter permease -
BI380_RS00885 165090..166223 + 1134 WP_017406196.1 ABC transporter permease -
BI380_RS00890 166236..167441 - 1206 WP_070080305.1 MFS transporter -
BI380_RS00895 167505..167951 - 447 WP_046240622.1 type II toxin-antitoxin system VapC family toxin Toxin
BI380_RS00900 167948..168214 - 267 WP_016453264.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BI380_RS00905 168239..169210 - 972 WP_034367441.1 LysR family transcriptional regulator -
BI380_RS00910 169287..170171 + 885 WP_046240627.1 amidohydrolase family protein -
BI380_RS00915 170198..171193 + 996 WP_070080306.1 tripartite tricarboxylate transporter substrate binding protein -
BI380_RS00920 171219..172850 - 1632 WP_070080307.1 gamma-glutamyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-133)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 15874.50 Da        Isoelectric Point: 9.0287

>T66508 WP_046240622.1 NZ_CP017420:c167951-167505 [Delftia tsuruhatensis]
MTRYLLDTNIASHIIKGDIPAVREQLVRVPMHQIAVSAVTQAELMYGVAKRGHPAGLSLRVTGFLARVEVLPWTAPVADA
YGHLRAACEAAGIRLASMDMMIAAHALLLQQQAAQAGERSVLVTRDRVFSRIPEPGLAIADWTTGPAG

Download         Length: 447 bp

>T66508 NZ_CP017420:c167951-167505 [Delftia tsuruhatensis]
ATGACACGCTACCTGCTGGACACCAACATCGCCAGCCACATCATCAAAGGCGATATCCCTGCCGTGCGCGAACAGCTGGT
TCGCGTACCCATGCACCAGATCGCCGTGTCGGCGGTCACGCAGGCCGAACTGATGTACGGGGTCGCCAAGCGCGGCCACC
CTGCCGGGCTGTCGCTGCGGGTGACAGGATTCCTGGCCCGCGTCGAGGTGCTGCCCTGGACGGCCCCGGTGGCCGATGCC
TACGGCCACCTGCGCGCCGCTTGCGAGGCGGCCGGCATCAGGCTGGCCTCCATGGACATGATGATTGCCGCGCACGCCCT
GCTCCTGCAGCAGCAGGCCGCGCAGGCCGGCGAGCGCTCGGTACTGGTCACAAGAGACCGGGTGTTCAGCCGCATTCCCG
AACCCGGACTGGCCATCGCGGACTGGACCACCGGCCCGGCTGGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10046.05 Da        Isoelectric Point: 4.3846

>AT66508 WP_016453264.1 NZ_CP017420:c168214-167948 [Delftia tsuruhatensis]
VTQTAKLFTTGRSQAVRLPYEFRFEEKEVYIRRDPVTGDVILSRRPDSWQEFFALDATTDVPADFMDTADRAQPESGRDP
FADEGSAR

Download         Length: 267 bp

>AT66508 NZ_CP017420:c168214-167948 [Delftia tsuruhatensis]
GTGACGCAGACTGCCAAGCTTTTCACCACCGGTCGCAGCCAGGCCGTGCGCCTTCCCTATGAATTCCGGTTCGAGGAAAA
AGAGGTCTACATACGTCGCGACCCCGTCACGGGCGACGTGATCCTGTCGCGCCGTCCCGACTCATGGCAAGAGTTCTTTG
CGCTCGACGCCACCACCGACGTGCCGGCCGATTTCATGGACACCGCTGACCGAGCGCAGCCAGAGTCAGGCCGCGATCCG
TTTGCCGACGAAGGCAGTGCGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D8IU07

Antitoxin

Source ID Structure
AlphaFold DB A0A1D8IU58

References