Detailed information of TA system TA066507

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 3445242..3446265
• Replicon: chromosome
• Accession: NZ_CP017415
• Organism: Acidihalobacter yilgarnenesis strain F5

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: A0A1D8IS81
• Locus tag: BI364_RS16565
• Protein ID: WP_070079675.1
• Coordinates: 3445242..3445805 (-)
• Length: 188 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: A0A1D8ISE6
• Locus tag: BI364_RS16570
• Protein ID: WP_070079676.1
• Coordinates: 3445810..3446265 (-)
• Length: 152 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BI364_RS16550	3441299..3442312	+	1014	WP_197496079.1	class 1 fructose-bisphosphatase	-
BI364_RS16555	3442754..3443401	+	648	WP_070080173.1	DUF2239 family protein	-
BI364_RS16560	3443547..3444446	+	900	WP_070079674.1	alpha/beta fold hydrolase	-
BI364_RS16565	3445242..3445805	-	564	WP_070079675.1	PIN domain-containing protein	Toxin
BI364_RS16570	3445810..3446265	-	456	WP_070079676.1	helix-turn-helix domain-containing protein	Antitoxin
BI364_RS16575	3446481..3446945	-	465	WP_070079677.1	GNAT family N-acetyltransferase	-
BI364_RS16580	3446994..3447608	-	615	WP_070079678.1	FMN-binding negative transcriptional regulator	-
BI364_RS16585	3447670..3449376	-	1707	WP_070079679.1	2-isopropylmalate synthase	-
BI364_RS18145	3450018..3450176	+	159	WP_156782816.1	hypothetical protein	-
BI364_RS18150	3450278..3450517	-	240	WP_156782817.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-110)

Antitoxin

• Helix-turn-helix domain, group 17 (81-129)

Sequences

Toxin

Protein

• Length: 188 a.a.
• Molecular weight: 21172.40 Da
• Isoelectric Point: 4.8029

>T66507 WP_070079675.1 NZ_CP017415:c3445805-3445242 [Acidihalobacter yilgarnenesis]
MRFIVVYDACVLYPAPLRDLLIRLAVTGLFAAKWTDQIHDEWIRNLVARRPELKKQMFRIRELMDDAVEDCLVTGYESLV
DGLDLPDPDDRHVLAAAIRAGAQLIVTCNLRDFPADKLEPYGIEAVHPDQFIVEQMDLHEGAVIEAVKQQRASLKNPPKS
VDDHLDTLSAQGLVVTADRLKEYRSLI

Nucleotide

• Length: 564 bp

>T66507 NZ_CP017415:c3445805-3445242 [Acidihalobacter yilgarnenesis]
ATGCGGTTTATCGTCGTCTATGACGCTTGTGTCTTGTACCCCGCACCTTTACGGGACTTGCTCATTAGGCTGGCTGTAAC
TGGTCTATTCGCCGCAAAGTGGACAGATCAGATCCATGATGAATGGATTCGAAACCTTGTCGCCCGGCGCCCAGAACTAA
AAAAGCAGATGTTTAGAATACGTGAGTTGATGGATGATGCTGTAGAGGATTGCTTGGTTACTGGATACGAAAGCCTTGTA
GACGGTCTGGACCTTCCAGATCCCGACGATCGCCATGTTCTTGCTGCGGCCATACGTGCGGGAGCGCAGCTGATCGTAAC
CTGCAACCTAAGGGACTTCCCGGCCGACAAGCTCGAGCCTTATGGGATTGAGGCAGTGCACCCGGATCAGTTTATCGTCG
AACAGATGGATCTACATGAAGGCGCTGTCATAGAAGCAGTGAAGCAGCAGCGAGCGTCTTTGAAGAACCCGCCTAAGTCA
GTAGATGACCATCTGGACACCCTCTCCGCTCAAGGATTAGTTGTGACCGCAGATAGGCTCAAGGAATATCGAAGCTTGAT
CTGA

Antitoxin

Protein

• Length: 152 a.a.
• Molecular weight: 17083.54 Da
• Isoelectric Point: 5.7450

>AT66507 WP_070079676.1 NZ_CP017415:c3446265-3445810 [Acidihalobacter yilgarnenesis]
MTVAQKLESALPDREQADLARESAAELSKLLANRPEIARARIQFDDTDLVLPRQAITLLRDLLAEMAQGNAVAVIPTHQE
LTTQQAADLLNVSRPHLIKLLEEGKLPFTKAGSHRRIRFEELLKYKEERDLRSQNAMDELAKQAQELNMGY

Nucleotide

• Length: 456 bp

>AT66507 NZ_CP017415:c3446265-3445810 [Acidihalobacter yilgarnenesis]
ATGACCGTTGCACAGAAGCTTGAATCCGCGCTTCCTGATCGCGAGCAGGCCGATCTTGCGCGTGAAAGCGCCGCTGAGCT
GAGTAAGCTTCTGGCCAATCGGCCAGAGATTGCGCGTGCGCGCATACAATTTGACGACACAGACCTAGTCTTACCGCGCC
AGGCGATAACCCTTTTGCGAGATTTGCTTGCCGAGATGGCCCAGGGTAATGCTGTCGCTGTTATACCAACCCACCAAGAG
CTGACCACACAACAAGCTGCGGACCTACTGAATGTGTCACGACCGCATCTGATAAAACTGCTTGAGGAAGGAAAGCTCCC
ATTCACGAAAGCAGGTAGTCATCGACGCATCCGCTTCGAAGAACTGCTCAAGTATAAAGAGGAGCGAGATCTGCGCAGCC
AGAACGCTATGGATGAGTTGGCGAAGCAGGCTCAGGAATTAAACATGGGGTACTGA

Structures

Toxin

• AlphaFold DB: A0A1D8IS81

Antitoxin

• AlphaFold DB: A0A1D8ISE6