Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 2774921..2776038 Replicon chromosome
Accession NZ_CP017415
Organism Acidihalobacter yilgarnenesis strain F5

Toxin (Protein)


Gene name - Uniprot ID A0A1D8IQZ6
Locus tag BI364_RS13405 Protein ID WP_070079181.1
Coordinates 2775292..2776038 (+) Length 249 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1D8IR19
Locus tag BI364_RS13400 Protein ID WP_070079180.1
Coordinates 2774921..2775289 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BI364_RS13375 2771300..2771683 - 384 WP_197495717.1 recombination regulator RecX -
BI364_RS13380 2771748..2772788 - 1041 WP_070080074.1 recombinase RecA -
BI364_RS13385 2772840..2773403 - 564 WP_070079178.1 RNA 2',3'-cyclic phosphodiesterase -
BI364_RS13390 2773390..2773878 - 489 WP_070080075.1 nicotinamide-nucleotide amidohydrolase family protein -
BI364_RS13395 2773979..2774809 + 831 WP_070079179.1 ferritin-like domain-containing protein -
BI364_RS13400 2774921..2775289 + 369 WP_070079180.1 MbcA/ParS/Xre antitoxin family protein Antitoxin
BI364_RS13405 2775292..2776038 + 747 WP_070079181.1 RES family NAD+ phosphorylase Toxin
BI364_RS13410 2776397..2777092 - 696 WP_070079182.1 APC family permease -
BI364_RS13415 2777812..2778075 + 264 WP_083251400.1 metalloregulator ArsR/SmtB family transcription factor -
BI364_RS13420 2778225..2779757 + 1533 WP_083251223.1 IS21 family transposase -
BI364_RS13425 2779789..2780547 + 759 WP_070078167.1 IS21-like element helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-204)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(7-67)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 27361.07 Da        Isoelectric Point: 6.6565

>T66506 WP_070079181.1 NZ_CP017415:2775292-2776038 [Acidihalobacter yilgarnenesis]
VDIWEACHGAHHIGALQISVYRVVESQARAATLDLVDTLAEQALLEELIEQTKPALPPTVMRLPYLLQSPFRYPPLRHGS
RFGGREVGGMFYASLNINTALAETAYYRFVFLTGMSSPPAGGVNTDLSSFRVGIRATHAVCLDIPPFDVYVDAISSRSTY
TTAQHLGDAMRREGVEVARYISARDPKHGRNLVVFSPGVFSGAPRDLRSWRCTTTVDRVVFVAAHHDEGLQFEREIFEVD
GHLPAPAP

Download         Length: 747 bp

>T66506 NZ_CP017415:2775292-2776038 [Acidihalobacter yilgarnenesis]
GTGGATATCTGGGAGGCCTGTCACGGCGCACACCATATCGGGGCACTGCAAATCTCCGTCTACCGTGTCGTCGAATCCCA
GGCGCGCGCCGCCACCCTGGATCTCGTCGACACCCTGGCCGAGCAGGCCCTGCTCGAAGAACTGATCGAGCAAACCAAGC
CGGCACTGCCGCCCACCGTCATGCGCCTACCCTATCTATTGCAAAGCCCCTTCCGCTACCCACCGTTACGCCACGGCTCG
CGCTTCGGCGGCCGCGAGGTTGGCGGCATGTTCTACGCCAGCCTGAACATAAACACCGCGCTAGCCGAAACGGCGTATTA
TCGATTCGTGTTCCTCACCGGCATGAGCTCGCCACCCGCGGGTGGGGTCAACACGGATCTGAGCAGCTTCCGAGTAGGCA
TACGCGCAACGCACGCCGTCTGTCTGGACATTCCACCCTTCGATGTCTATGTGGACGCCATCTCATCCAGATCGACCTAC
ACCACCGCCCAGCATCTTGGAGACGCCATGCGCCGCGAAGGCGTTGAAGTGGCCCGCTATATTTCTGCGCGCGATCCCAA
ACATGGGCGCAATCTCGTGGTCTTCAGTCCCGGTGTATTCAGCGGCGCCCCACGCGACCTGCGCAGTTGGCGTTGCACCA
CGACCGTCGATCGCGTCGTGTTCGTCGCAGCACACCACGATGAGGGTCTTCAGTTCGAGCGCGAGATCTTCGAAGTGGAC
GGACATCTCCCCGCACCTGCTCCCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13735.93 Da        Isoelectric Point: 10.7475

>AT66506 WP_070079180.1 NZ_CP017415:2774921-2775289 [Acidihalobacter yilgarnenesis]
MNQQQRHAEEKSVLAKALFNAAGSLGIKIGELAFILGCDRSTLQRHRRNGSLDPASKSGELSLLLIRVYRDLYALMGGNR
VHMQHWLNTENRHLHAMPRQMLTRVEGLTAVLAYLDAMRGKT

Download         Length: 369 bp

>AT66506 NZ_CP017415:2774921-2775289 [Acidihalobacter yilgarnenesis]
ATGAACCAGCAACAACGCCATGCCGAGGAAAAATCTGTGCTTGCCAAGGCGCTCTTCAATGCGGCCGGCAGCTTGGGGAT
CAAAATCGGCGAACTGGCCTTTATCCTCGGATGCGACCGCTCCACGCTACAGCGCCACCGGCGCAACGGTAGCCTAGACC
CGGCCAGCAAGAGCGGGGAATTATCTCTGCTGCTGATTCGCGTTTACCGCGATCTGTACGCGCTCATGGGCGGCAATAGA
GTCCACATGCAACATTGGCTGAACACCGAAAACCGACACCTGCATGCCATGCCCCGACAGATGTTGACGCGGGTCGAGGG
CTTGACCGCCGTGCTGGCCTATCTGGATGCAATGCGAGGCAAGACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D8IQZ6

Antitoxin

Source ID Structure
AlphaFold DB A0A1D8IR19

References