66504

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 2096885..2097365 Replicon chromosome
Accession NZ_CP017415
Organism Acidihalobacter yilgarnenesis strain F5

Toxin (Protein)


Gene name pasB Uniprot ID A0A1D8IP56
Locus tag BI364_RS09980 Protein ID WP_070078606.1
Coordinates 2096885..2097154 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A1D8IP71
Locus tag BI364_RS09985 Protein ID WP_070078607.1
Coordinates 2097138..2097365 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BI364_RS09970 2094270..2094986 + 717 WP_070078604.1 hypothetical protein -
BI364_RS09975 2095053..2096756 - 1704 WP_070078605.1 hypothetical protein -
BI364_RS09980 2096885..2097154 - 270 WP_070078606.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BI364_RS09985 2097138..2097365 - 228 WP_070078607.1 TraY domain-containing protein Antitoxin
BI364_RS17425 2097582..2097902 + 321 WP_083251298.1 type II toxin-antitoxin system RelE/ParE family toxin -
BI364_RS09990 2097889..2098197 + 309 WP_070078608.1 helix-turn-helix domain-containing protein -
BI364_RS09995 2098290..2098493 - 204 WP_070078609.1 hypothetical protein -
BI364_RS10000 2098490..2098669 - 180 WP_070078610.1 hypothetical protein -
BI364_RS10005 2098668..2099297 + 630 WP_070078611.1 IS607 family transposase -
BI364_RS10010 2099294..2100496 + 1203 WP_070078612.1 transposase -
BI364_RS10015 2100620..2100805 - 186 WP_070078613.1 hypothetical protein -
BI364_RS10020 2100802..2101194 - 393 WP_070078614.1 hypothetical protein -
BI364_RS10025 2101344..2101931 - 588 WP_156782702.1 hypothetical protein -
BI364_RS10030 2101924..2102337 - 414 WP_156782703.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-88)

Antitoxin

Relaxosome protein TraY

(3-50)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10395.14 Da        Isoelectric Point: 10.2749

>T66504 WP_070078606.1 NZ_CP017415:c2097154-2096885 [Acidihalobacter yilgarnenesis]
MVWTVKFERSAERELSKLDPQIARRILVFLHDRLAQLDDPRSIGEALKGAKLGAFWKYRVGDYRVIASIEDAELCVLVLR
IGNRRHVYR

Download         Length: 270 bp

>T66504 NZ_CP017415:c2097154-2096885 [Acidihalobacter yilgarnenesis]
ATGGTCTGGACGGTTAAGTTCGAGCGATCGGCCGAGCGCGAACTATCCAAACTCGATCCGCAGATCGCGCGCCGCATTCT
CGTTTTCTTGCATGACCGCCTGGCGCAGCTGGATGACCCGCGAAGCATTGGCGAAGCGCTGAAAGGGGCCAAGCTGGGCG
CATTCTGGAAATACCGGGTTGGCGACTATCGCGTTATCGCCAGCATCGAGGACGCCGAACTTTGCGTTCTCGTTCTGAGA
ATTGGAAACAGGCGGCACGTATACCGTTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8337.38 Da        Isoelectric Point: 4.2924

>AT66504 WP_070078607.1 NZ_CP017415:c2097365-2097138 [Acidihalobacter yilgarnenesis]
MPISIRLPSDVEARLNELAARTGRSKTFYATEAIIDHLDDLEDVYLAEQRLVDLRAGKSDAVSLDDLMARYGLDG

Download         Length: 228 bp

>AT66504 NZ_CP017415:c2097365-2097138 [Acidihalobacter yilgarnenesis]
ATGCCGATTTCAATCCGACTCCCCAGCGATGTTGAAGCCAGGCTTAACGAGTTGGCGGCGCGCACGGGACGCAGCAAGAC
ATTCTACGCCACCGAAGCGATCATCGATCACCTTGATGATCTCGAAGACGTATACCTCGCCGAGCAACGTCTTGTAGACC
TGCGCGCAGGCAAGTCGGACGCTGTTTCGCTTGATGATCTGATGGCGCGGTATGGTCTGGACGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D8IP56

Antitoxin

Source ID Structure
AlphaFold DB A0A1D8IP71

References