Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1604155..1605700 Replicon chromosome
Accession NZ_CP017415
Organism Acidihalobacter yilgarnenesis strain F5

Toxin (Protein)


Gene name HipA1 Uniprot ID A0A1D8IN74
Locus tag BI364_RS07710 Protein ID WP_070078240.1
Coordinates 1604155..1605450 (-) Length 432 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID A0A1D8IN63
Locus tag BI364_RS07715 Protein ID WP_070078241.1
Coordinates 1605440..1605700 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BI364_RS07695 1601136..1602272 + 1137 WP_070078237.1 hypothetical protein -
BI364_RS17340 1602322..1602528 - 207 WP_083251238.1 DUF3079 domain-containing protein -
BI364_RS07705 1602855..1603727 - 873 WP_070078239.1 glutathione-dependent disulfide-bond oxidoreductase -
BI364_RS07710 1604155..1605450 - 1296 WP_070078240.1 type II toxin-antitoxin system HipA family toxin Toxin
BI364_RS07715 1605440..1605700 - 261 WP_070078241.1 helix-turn-helix transcriptional regulator Antitoxin
BI364_RS07720 1606018..1606314 - 297 WP_070078242.1 IS5 family transposase -
BI364_RS07725 1606931..1607827 + 897 WP_083251239.1 sel1 repeat family protein -
BI364_RS07730 1608166..1608507 - 342 WP_070078244.1 type II toxin-antitoxin system RelE/ParE family toxin -
BI364_RS07735 1608507..1608782 - 276 WP_070078245.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-102)

Antitoxin

Transcription regulator, HipB-like

(9-65)


Sequences

Toxin        


Download         Length: 432 a.a.        Molecular weight: 47535.73 Da        Isoelectric Point: 6.9482

>T66503 WP_070078240.1 NZ_CP017415:c1605450-1604155 [Acidihalobacter yilgarnenesis]
MMHELEVWLFAERVGTLALIDGRLNFRYAPGCLSHKEAVALSASLPLQAEPFDDRKTRPFFAGLLPEGQMRRLIAQQFQV
SGQNDFALLDHIGGECAGAVTFLEPGQTLPVPTRSDDVQWLSDEEVVAILDELPRRPMLAGKDGLRLSLAGAQDKLPVVF
DGARIGLPLNGTPSSHILKSPIHAVEDSVINEGFCMALAEAMQFKPAKSKVHQVLSRSFLLVERYDRLIDAQGHRQRLHQ
EDFCQALCVVPEMKHQNEGGPDLAQCFDLVRSATRPSAPQVLRLFDCVIFNALIGNHDAHAKNFSLLYSGKAPVLAPFYD
TLSTAVYPTLTPKMAMKIGSKYKFSEVQARHWEQFAVGVGFTKAQAKRRILELAKLLPATARKLQSDPGHCFAGNAVVEQ
LNTLIEQRCALTIRRLTDPAAENDIAAEPSV

Download         Length: 1296 bp

>T66503 NZ_CP017415:c1605450-1604155 [Acidihalobacter yilgarnenesis]
ATGATGCATGAGCTGGAAGTCTGGCTTTTTGCCGAGCGTGTCGGCACGTTGGCGCTGATCGATGGCCGACTGAACTTTCG
GTACGCACCCGGCTGTCTGTCACACAAAGAAGCTGTTGCCTTGTCCGCCTCGCTGCCCCTGCAAGCGGAGCCGTTCGACG
ATCGTAAAACGCGTCCCTTCTTTGCCGGTCTTTTACCCGAAGGGCAGATGCGCCGCCTGATTGCGCAGCAGTTCCAGGTT
TCTGGCCAGAACGACTTTGCGCTGCTGGATCACATCGGTGGCGAATGCGCCGGGGCCGTCACCTTCTTGGAGCCCGGACA
GACTTTGCCTGTACCGACCCGCAGCGATGACGTTCAATGGCTGAGCGACGAGGAAGTCGTTGCCATCCTGGATGAGTTGC
CGCGTCGCCCCATGTTGGCGGGCAAAGACGGCTTGCGGCTTTCATTGGCTGGTGCTCAAGACAAACTACCGGTGGTGTTT
GATGGTGCCCGCATTGGTCTGCCCCTCAATGGCACGCCGAGCTCACACATCTTGAAATCCCCCATTCACGCCGTTGAAGA
CAGCGTGATCAACGAGGGATTTTGCATGGCGCTGGCTGAGGCCATGCAGTTCAAGCCAGCGAAATCAAAAGTTCACCAGG
TATTGAGCCGGTCCTTTCTACTGGTTGAGCGTTACGACCGACTGATCGATGCGCAGGGGCACCGACAACGCCTTCATCAA
GAGGATTTCTGCCAAGCGCTATGTGTGGTGCCAGAAATGAAACACCAAAATGAAGGAGGGCCGGATCTGGCCCAGTGCTT
TGACCTGGTACGCAGTGCGACGCGCCCCAGCGCACCGCAGGTTCTGCGGCTGTTCGACTGCGTGATCTTTAATGCCCTGA
TCGGCAATCACGATGCGCACGCCAAGAATTTCTCTCTGCTGTACTCAGGCAAGGCCCCCGTTCTGGCGCCGTTTTACGAC
ACGCTGTCGACGGCGGTGTATCCAACATTGACGCCGAAGATGGCGATGAAAATCGGCAGCAAGTACAAATTCAGCGAAGT
CCAGGCGCGGCACTGGGAGCAGTTCGCCGTAGGCGTAGGCTTTACCAAGGCGCAAGCCAAACGGCGCATTCTGGAATTGG
CAAAGTTACTGCCAGCGACGGCGCGCAAGCTCCAATCTGACCCCGGACACTGTTTTGCTGGCAATGCCGTGGTTGAGCAA
CTCAATACCTTGATTGAACAACGCTGCGCCCTGACGATTCGGAGGCTCACCGATCCCGCCGCCGAAAATGACATAGCCGC
TGAACCCTCTGTCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9044.30 Da        Isoelectric Point: 5.0022

>AT66503 WP_070078241.1 NZ_CP017415:c1605700-1605440 [Acidihalobacter yilgarnenesis]
MTSIRSPQQLGDALRAARKQLGLTQPQLALAAGVGVRFIVDLEAGKPTLRLENVLRVIDALGGEIQLSGLPAVATEDRSE
GSDHDA

Download         Length: 261 bp

>AT66503 NZ_CP017415:c1605700-1605440 [Acidihalobacter yilgarnenesis]
ATGACATCCATTCGATCACCTCAACAACTCGGCGATGCACTGCGTGCCGCTCGCAAGCAGCTCGGGCTGACACAGCCTCA
GTTGGCATTGGCGGCAGGGGTTGGTGTGCGCTTCATTGTCGACCTTGAAGCAGGCAAGCCTACCTTGCGACTGGAAAACG
TACTCCGGGTCATTGATGCCTTGGGTGGTGAGATCCAGTTGAGCGGATTGCCCGCCGTTGCAACCGAAGATCGAAGTGAG
GGCTCCGACCATGATGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D8IN74

Antitoxin

Source ID Structure
AlphaFold DB A0A1D8IN63

References