Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1491231..1491868 Replicon chromosome
Accession NZ_CP017415
Organism Acidihalobacter yilgarnenesis strain F5

Toxin (Protein)


Gene name relE Uniprot ID A0A1D8IMW6
Locus tag BI364_RS07130 Protein ID WP_070078150.1
Coordinates 1491569..1491868 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1D8IMW9
Locus tag BI364_RS07125 Protein ID WP_070078149.1
Coordinates 1491231..1491566 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BI364_RS07105 1486505..1487920 + 1416 WP_070078145.1 hypothetical protein -
BI364_RS07110 1487938..1488453 + 516 WP_070078146.1 hypothetical protein -
BI364_RS07115 1488526..1490229 + 1704 WP_070078147.1 hypothetical protein -
BI364_RS07120 1490299..1491027 - 729 WP_070078148.1 hypothetical protein -
BI364_RS07125 1491231..1491566 - 336 WP_070078149.1 putative addiction module antidote protein Antitoxin
BI364_RS07130 1491569..1491868 - 300 WP_070078150.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BI364_RS07135 1492393..1493034 + 642 WP_070078151.1 hypothetical protein -
BI364_RS17295 1493043..1494116 + 1074 WP_083251222.1 ImmA/IrrE family metallo-endopeptidase -
BI364_RS07145 1494154..1495338 + 1185 WP_156782650.1 hypothetical protein -
BI364_RS07150 1495488..1495931 - 444 WP_070078154.1 type II toxin-antitoxin system VapC family toxin -
BI364_RS07155 1495928..1496173 - 246 WP_070078155.1 prevent-host-death protein -
BI364_RS07160 1496190..1496450 - 261 WP_197495928.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-91)

Antitoxin

Uncharacterized protein HI1420

(12-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11260.07 Da        Isoelectric Point: 10.3353

>T66501 WP_070078150.1 NZ_CP017415:c1491868-1491569 [Acidihalobacter yilgarnenesis]
MSYTVKLLGEFEDWLKSLKDGRTKLRLSKRLRKVQLGNLSDVAPVGEGVFEMREHFGPGWRMYYILRGETVIVMLAGGNK
STQQADIRRATTLAKSLED

Download         Length: 300 bp

>T66501 NZ_CP017415:c1491868-1491569 [Acidihalobacter yilgarnenesis]
ATGTCCTATACGGTGAAACTTCTCGGCGAGTTCGAGGACTGGCTCAAAAGTCTGAAGGACGGGCGAACCAAGCTGCGACT
TAGCAAACGTCTACGCAAAGTTCAGTTGGGTAACTTGAGCGATGTGGCGCCGGTGGGCGAAGGCGTATTTGAGATGCGCG
AGCACTTCGGACCAGGCTGGCGCATGTACTACATCCTGCGCGGCGAGACCGTGATTGTGATGCTTGCCGGCGGTAACAAG
TCCACTCAGCAAGCCGACATCCGTCGTGCCACCACGCTGGCGAAGTCCCTGGAGGATTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12154.73 Da        Isoelectric Point: 4.4547

>AT66501 WP_070078149.1 NZ_CP017415:c1491566-1491231 [Acidihalobacter yilgarnenesis]
MTQRIKISELPEFDVSEYLNNDEDVAEYLTAILEENDPALLAAALGDIARARGMSQVAKDSGIAREALYKALRPGSEPRF
ETISRVCTALGVRLVVQPTHVAHTDMPQESA

Download         Length: 336 bp

>AT66501 NZ_CP017415:c1491566-1491231 [Acidihalobacter yilgarnenesis]
ATGACCCAAAGAATCAAGATTTCCGAACTGCCCGAGTTTGATGTGTCGGAGTACTTAAATAACGACGAGGATGTGGCGGA
ATACCTGACGGCCATTCTCGAAGAGAATGACCCAGCCCTACTGGCTGCAGCCCTCGGCGACATTGCTCGCGCACGTGGGA
TGTCTCAGGTTGCAAAGGATTCCGGCATTGCACGCGAAGCGCTATATAAGGCGCTTCGACCTGGCAGCGAGCCGCGTTTC
GAGACTATTAGCCGTGTTTGCACGGCCTTGGGCGTCCGTCTGGTCGTGCAGCCGACGCACGTCGCGCACACCGATATGCC
CCAAGAGTCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D8IMW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1D8IMW9

References