Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09907-MazE
Location 8792..9393 Replicon plasmid pL1277-4
Accession NZ_CP017367
Organism Lactiplantibacillus plantarum strain TMW 1.277

Toxin (Protein)


Gene name pemK Uniprot ID Q684P1
Locus tag BIZ32_RS16110 Protein ID WP_001748110.1
Coordinates 8792..9136 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID Q684P2
Locus tag BIZ32_RS16115 Protein ID WP_003643337.1
Coordinates 9130..9393 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BIZ32_RS16090 4152..4334 - 183 WP_033609921.1 hypothetical protein -
BIZ32_RS16095 5020..5508 - 489 WP_085764828.1 hypothetical protein -
BIZ32_RS16100 5999..6997 - 999 WP_016527164.1 IS30 family transposase -
BIZ32_RS16105 7271..8542 + 1272 WP_085764829.1 polysaccharide deacetylase family protein -
BIZ32_RS16110 8792..9136 - 345 WP_001748110.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BIZ32_RS16115 9130..9393 - 264 WP_003643337.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BIZ32_RS16120 9479..10066 + 588 WP_003646144.1 site-specific integrase -
BIZ32_RS16835 10349..10438 + 90 Protein_15 IS30 family transposase -
BIZ32_RS16130 11461..11949 + 489 Protein_16 replication initiation protein -
BIZ32_RS16140 12484..13659 + 1176 WP_085764831.1 IS256 family transposase -
BIZ32_RS16840 13916..14116 + 201 Protein_18 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..31304 31304


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)

Antitoxin

Toxin YoeB

(8-87)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 16943.32 Da        Isoelectric Point: 5.5500

>T66491 WP_001748110.1 NZ_CP017367:c9136-8792 [Lactiplantibacillus plantarum]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 345 bp

>T66491 NZ_CP017367:c9136-8792 [Lactiplantibacillus plantarum]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 12969.56 Da        Isoelectric Point: 5.5500

>AT66491 WP_003643337.1 NZ_CP017367:c9393-9130 [Lactiplantibacillus plantarum]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFF

Download         Length: 264 bp

>AT66491 NZ_CP017367:c9393-9130 [Lactiplantibacillus plantarum]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R2K1X3

Antitoxin

Source ID Structure
AlphaFold DB A0A6L4ZZT2

References