Detailed information of TA system TA066484

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): slvAT/RES(toxin)
• Location: 1071635..1072530
• Replicon: chromosome
• Accession: NZ_CP017353
• Organism: Pseudomonas aeruginosa strain FA-HZ1

Toxin (Protein)

• Gene name: slvT
• Uniprot ID: A0A318E8F0
• Locus tag: BHE76_RS05190
• Protein ID: WP_023093160.1
• Coordinates: 1071635..1072162 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: slvA
• Uniprot ID: A0A318DY98
• Locus tag: BHE76_RS05195
• Protein ID: WP_023093161.1
• Coordinates: 1072159..1072530 (-)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BHE76_RS05170	1067428..1069443	-	2016	WP_023093157.1	DNA topoisomerase III	-
BHE76_RS05175	1069738..1070121	-	384	WP_004362284.1	single-stranded DNA-binding protein	-
BHE76_RS05180	1070118..1070666	-	549	WP_023093158.1	DUF3158 family protein	-
BHE76_RS05185	1070663..1071451	-	789	WP_023093159.1	TIGR03761 family integrating conjugative element protein	-
BHE76_RS05190	1071635..1072162	-	528	WP_023093160.1	RES family NAD+ phosphorylase	Toxin
BHE76_RS05195	1072159..1072530	-	372	WP_023093161.1	hypothetical protein	Antitoxin
BHE76_RS05200	1072651..1073844	-	1194	WP_023093162.1	hypothetical protein	-
BHE76_RS05205	1073848..1074408	-	561	WP_023093163.1	DUF2857 domain-containing protein	-
BHE76_RS05210	1074426..1076084	-	1659	WP_023093164.1	ParB family protein	-
BHE76_RS05215	1076077..1076313	-	237	WP_012584779.1	hypothetical protein	-
BHE76_RS05220	1076297..1077162	-	866	Protein_1054	ParA family protein	-
BHE76_RS05225	1077203..1077421	-	219	WP_016446183.1	AlpA family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	960726..1103330	142604

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (11-169)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19831.28 Da
• Isoelectric Point: 5.2440

>T66484 WP_023093160.1 NZ_CP017353:c1072162-1071635 [Pseudomonas aeruginosa]
MILLDLPPGTTLFRAHTPQWASRPTSGAGAAAKGGRFNREGVEALYLSLEEATALREYQQTSPFLPPCTMCSYTVALREL
VDLRQLHRGEPWDELWHDWREDWRHLKFDLHIEPPTWVLGDMVLAQGHTGILFPSQANDGGTNIVVFVDRLRDGNSVEVN
DPDGRLPRDQSSWTR

Nucleotide

• Length: 528 bp

>T66484 NZ_CP017353:c1072162-1071635 [Pseudomonas aeruginosa]
ATGATCCTCCTCGACCTGCCGCCCGGCACCACGCTGTTTCGCGCGCACACCCCGCAGTGGGCCAGCCGGCCAACCAGCGG
CGCTGGTGCGGCGGCCAAGGGCGGGCGCTTCAACCGGGAGGGCGTCGAGGCGCTGTATCTGTCGCTGGAGGAAGCGACCG
CGCTACGCGAATACCAGCAGACCTCGCCCTTCCTGCCGCCCTGCACGATGTGCTCGTACACCGTGGCATTGCGCGAGCTG
GTCGATCTGCGGCAGCTCCACCGCGGCGAACCTTGGGACGAGCTGTGGCACGACTGGCGCGAGGACTGGCGCCATCTGAA
ATTCGACCTTCACATCGAGCCGCCCACTTGGGTGCTGGGCGACATGGTGCTGGCCCAGGGCCATACCGGAATCCTGTTCC
CCAGCCAGGCGAACGATGGCGGCACCAATATCGTGGTGTTCGTGGATCGGCTCAGGGATGGCAATTCGGTCGAGGTCAAT
GATCCCGACGGGCGACTGCCCCGCGACCAATCCAGTTGGACGCGCTGA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13358.05 Da
• Isoelectric Point: 6.0705

>AT66484 WP_023093161.1 NZ_CP017353:c1072530-1072159 [Pseudomonas aeruginosa]
MASTAFADVLESVREAGTSRFSATNVADALGLQYQDLATLAGVHRNTLRTHPESPRLQAALRDLMRVLSAASAVQPDTAR
AFFMVKNEPIPTFHHKTLLQLVQEGRTDDAIDYLESISAGFTG

Nucleotide

• Length: 372 bp

>AT66484 NZ_CP017353:c1072530-1072159 [Pseudomonas aeruginosa]
ATGGCCTCTACCGCTTTCGCGGATGTGCTCGAATCGGTGCGTGAAGCCGGCACGTCCCGCTTTTCCGCCACGAACGTCGC
CGATGCCCTGGGCCTGCAGTACCAGGACTTGGCCACGCTGGCTGGCGTGCACCGCAACACCCTGCGCACCCACCCCGAGT
CACCGCGACTCCAGGCCGCGCTTCGTGACCTGATGCGGGTGCTATCGGCCGCCTCGGCGGTGCAGCCGGATACCGCGCGT
GCATTCTTCATGGTCAAGAACGAGCCCATCCCGACGTTCCACCACAAGACCCTGCTGCAGTTGGTGCAGGAAGGACGCAC
CGACGATGCGATCGACTACCTGGAGTCGATCAGTGCAGGGTTCACCGGATGA

Structures

Toxin

• AlphaFold DB: A0A318E8F0

Antitoxin

• AlphaFold DB: A0A318DY98