Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 5103667..5104313 Replicon chromosome
Accession NZ_CP017311
Organism Hydrogenophaga sp. PBC

Toxin (Protein)


Gene name relE Uniprot ID A0A1L1PGF7
Locus tag Q5W_RS24295 Protein ID WP_009517440.1
Coordinates 5104002..5104313 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A1L1PWZ3
Locus tag Q5W_RS24290 Protein ID WP_009517439.1
Coordinates 5103667..5103996 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Q5W_RS24275 5099337..5100152 + 816 WP_009516261.1 ABC transporter ATP-binding protein -
Q5W_RS24280 5100149..5100967 + 819 WP_009516260.1 ABC transporter ATP-binding protein -
Q5W_RS24285 5101003..5102457 + 1455 WP_009516259.1 aldehyde dehydrogenase -
Q5W_RS26090 5102621..5102782 + 162 WP_009516258.1 hypothetical protein -
Q5W_RS25930 5102867..5103124 + 258 Protein_4873 IS21 family transposase -
Q5W_RS25555 5103307..5103528 - 222 WP_081921992.1 YHYH domain-containing protein -
Q5W_RS24290 5103667..5103996 - 330 WP_009517439.1 putative addiction module antidote protein Antitoxin
Q5W_RS24295 5104002..5104313 - 312 WP_009517440.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Q5W_RS24300 5104408..5104836 - 429 WP_138820224.1 hypothetical protein -
Q5W_RS24305 5104962..5105522 + 561 WP_009517442.1 dihydrofolate reductase family protein -
Q5W_RS24310 5105529..5106008 - 480 WP_009517443.1 hypothetical protein -
Q5W_RS24315 5106167..5107492 + 1326 WP_009517444.1 tryptophan 7-halogenase -
Q5W_RS24320 5107531..5108412 - 882 WP_084462999.1 class I SAM-dependent methyltransferase -
Q5W_RS24325 5108355..5108996 - 642 WP_009517446.1 lysoplasmalogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(60-103)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11677.45 Da        Isoelectric Point: 10.1238

>T66471 WP_009517440.1 NZ_CP017311:c5104313-5104002 [Hydrogenophaga sp. PBC]
MSYITFPRIVETHEYRQWILGLRDRAGRARILVRVDRLIHGNPGDHRQLTDGVSELKIDVGPGYRVYYAQRGKVLLLLLA
GGDKSTQTKDIAKAIALARGYEE

Download         Length: 312 bp

>T66471 NZ_CP017311:c5104313-5104002 [Hydrogenophaga sp. PBC]
ATGAGCTACATTACGTTCCCGCGCATCGTAGAGACCCATGAATACAGACAGTGGATTCTTGGCCTGCGCGACCGCGCGGG
GCGCGCCCGGATTCTGGTCCGCGTTGATCGTCTGATCCACGGCAACCCCGGAGATCACCGTCAGCTCACAGACGGCGTGA
GCGAACTCAAGATCGACGTCGGTCCAGGCTACCGGGTCTACTACGCGCAGCGCGGCAAGGTGCTGCTCCTGCTGTTGGCG
GGCGGTGACAAATCCACCCAGACCAAAGACATCGCCAAGGCCATTGCCTTGGCCCGGGGATACGAGGAGTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11455.00 Da        Isoelectric Point: 10.0255

>AT66471 WP_009517439.1 NZ_CP017311:c5103996-5103667 [Hydrogenophaga sp. PBC]
MRKSTSTKPASKRATKTTPYDVASYLSSPEDMAAYLDAWLTEAPDDAAGIARALGDIARAKGMTQVAKDAGLSRESLYRA
LSPEGNPSFATVLKVAKALGVRLHAQAAS

Download         Length: 330 bp

>AT66471 NZ_CP017311:c5103996-5103667 [Hydrogenophaga sp. PBC]
ATGCGCAAGAGCACCAGCACGAAGCCCGCCAGCAAACGCGCCACCAAAACCACGCCATACGACGTGGCCTCCTATCTGAG
CAGCCCCGAAGACATGGCGGCCTACCTGGATGCTTGGTTGACCGAAGCCCCCGACGACGCGGCCGGCATTGCGCGCGCGC
TGGGCGACATTGCCCGCGCCAAGGGCATGACGCAAGTGGCCAAAGACGCGGGGCTCAGCCGAGAAAGTCTGTACCGCGCA
CTGAGCCCTGAGGGCAATCCCAGCTTTGCGACCGTGCTCAAGGTGGCGAAGGCACTGGGTGTGCGCTTGCACGCGCAAGC
CGCAAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L1PGF7

Antitoxin

Source ID Structure
AlphaFold DB A0A1L1PWZ3

References