Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 4605587..4607247 Replicon chromosome
Accession NZ_CP017311
Organism Hydrogenophaga sp. PBC

Toxin (Protein)


Gene name HipA3 Uniprot ID A0A1L1PP22
Locus tag Q5W_RS21915 Protein ID WP_009515044.1
Coordinates 4605587..4606927 (-) Length 447 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID A0A1L1PS24
Locus tag Q5W_RS21920 Protein ID WP_009515046.1
Coordinates 4606933..4607247 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Q5W_RS21890 4601620..4601940 + 321 WP_009520730.1 hypothetical protein -
Q5W_RS21895 4601990..4602823 - 834 WP_009520741.1 IS21-like element helper ATPase IstB -
Q5W_RS21900 4602820..4604343 - 1524 WP_030093096.1 IS21 family transposase -
Q5W_RS21905 4604514..4604969 + 456 WP_069903071.1 hypothetical protein -
Q5W_RS25895 4605101..4605280 - 180 WP_009515042.1 hypothetical protein -
Q5W_RS21915 4605587..4606927 - 1341 WP_009515044.1 type II toxin-antitoxin system HipA family toxin Toxin
Q5W_RS21920 4606933..4607247 - 315 WP_009515046.1 helix-turn-helix transcriptional regulator Antitoxin
Q5W_RS21925 4607473..4607967 - 495 WP_039877498.1 hypothetical protein -
Q5W_RS21930 4607967..4608407 - 441 WP_009515050.1 hypothetical protein -
Q5W_RS21935 4608563..4609105 - 543 WP_009515052.1 helix-turn-helix domain-containing protein -
Q5W_RS21940 4609380..4610657 + 1278 WP_081921957.1 YifB family Mg chelatase-like AAA ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4578820..4609105 30285


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(23-135)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-70)


Sequences

Toxin        


Download         Length: 447 a.a.        Molecular weight: 50070.24 Da        Isoelectric Point: 6.9208

>T66468 WP_009515044.1 NZ_CP017311:c4606927-4605587 [Hydrogenophaga sp. PBC]
MATTKPKSKPTRKSPYSPVRAVEVRAWGKLVGAVALEPTKNYYAFSYDPSWVKRGIELAPLRMPLEQASEPFLFTDLPEA
TYKRLPAMLADALPDDFGNALIDAWMAERGLSKGMVSALDRLAYMGKRGMGALTFGPLRGPPASKPTVIEMGKLVESARK
AVQGDFDGDDHAITALKQIIQVGTSAGGARAKATIAWNPITDEVRTGQFDIPDGFEAWLLKFDGMGVDNELGPSKSYGRI
EYAYYLMADAANIDMSPCRLLRENGRAHFMTKRFDREGNERLHMQTLCAMAHLDYKLVGTHSYNQLLQTAQALKLDRKAM
VQLLRRMIFNVLAVNNDDHTKNFSFLLRQGEQWELAPAYDITHAYRVDSDWVSQHQMSINGKFDRITLADVRVVADRFGL
LADLAAAVEDVRRAVSRWVEFADEAQVDPIERDEIERQMGERDRVF

Download         Length: 1341 bp

>T66468 NZ_CP017311:c4606927-4605587 [Hydrogenophaga sp. PBC]
ATGGCCACAACCAAACCGAAATCCAAGCCCACACGCAAGAGCCCCTACAGCCCCGTGCGCGCGGTCGAGGTCCGCGCCTG
GGGCAAACTGGTTGGCGCGGTTGCTCTGGAGCCCACGAAGAACTACTACGCATTCAGCTACGACCCTTCCTGGGTCAAGC
GAGGCATTGAGTTGGCGCCGCTGCGGATGCCGCTTGAACAGGCCAGCGAGCCCTTCCTGTTCACGGATCTCCCCGAGGCG
ACCTACAAGCGCTTGCCGGCGATGCTGGCCGATGCGCTGCCCGACGACTTCGGCAATGCCCTCATCGATGCCTGGATGGC
CGAGCGAGGCTTGAGCAAGGGCATGGTGAGCGCGCTCGATCGCCTGGCCTACATGGGAAAGCGCGGCATGGGCGCTCTCA
CTTTCGGGCCGTTGCGTGGCCCACCAGCGAGCAAGCCCACGGTGATCGAGATGGGCAAGCTGGTCGAGTCGGCCCGAAAG
GCGGTGCAAGGTGACTTCGATGGTGACGACCACGCCATCACCGCCCTCAAGCAGATCATCCAGGTAGGCACCTCCGCGGG
TGGCGCGCGTGCGAAGGCGACCATCGCCTGGAACCCGATCACAGACGAGGTTCGCACAGGTCAGTTCGATATCCCAGACG
GGTTTGAGGCCTGGCTGCTCAAGTTTGACGGGATGGGCGTGGACAACGAGCTGGGCCCGTCCAAGAGCTACGGACGCATC
GAGTACGCCTACTATCTGATGGCCGATGCCGCAAACATCGACATGTCGCCATGCCGGCTGCTTCGAGAAAACGGCCGCGC
GCACTTCATGACCAAGCGATTTGACCGCGAGGGCAATGAGCGGCTGCACATGCAGACCCTGTGCGCAATGGCACACCTGG
ACTACAAGCTGGTTGGCACGCACAGCTACAACCAGTTGCTGCAGACCGCCCAGGCACTCAAGCTTGATCGCAAGGCCATG
GTGCAACTGCTGCGCCGAATGATCTTCAACGTGCTGGCCGTCAACAATGACGATCACACCAAGAACTTCTCCTTCCTGCT
GCGACAGGGGGAGCAGTGGGAGCTTGCCCCGGCGTACGACATCACGCATGCCTACCGTGTCGATAGCGACTGGGTGAGCC
AGCATCAGATGTCCATCAATGGCAAGTTTGACCGCATCACTCTCGCCGATGTGCGGGTGGTGGCAGATCGATTCGGTCTC
CTCGCAGACCTGGCTGCTGCGGTGGAGGATGTACGCAGAGCGGTCAGCCGATGGGTTGAGTTCGCCGATGAAGCGCAGGT
GGATCCAATTGAGCGCGATGAGATCGAGCGGCAGATGGGCGAGCGCGACCGGGTGTTTTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11654.44 Da        Isoelectric Point: 10.7217

>AT66468 WP_009515046.1 NZ_CP017311:c4607247-4606933 [Hydrogenophaga sp. PBC]
MQSTHTTDELLLELGEQLRSQRLRMNLTLEDVAKDAGVSINVVRRLELGEGATLGSFVSVLRVLGRADWLATLKPPVTIN
PLDMLRQVEQRQRASKPHGVNRKN

Download         Length: 315 bp

>AT66468 NZ_CP017311:c4607247-4606933 [Hydrogenophaga sp. PBC]
ATGCAGTCAACTCATACCACCGACGAACTCCTTCTCGAACTGGGAGAGCAACTGCGCTCCCAACGGCTGCGCATGAACCT
CACGCTGGAGGACGTGGCCAAGGACGCAGGCGTTTCAATCAACGTGGTGCGCCGCCTGGAACTAGGCGAGGGCGCGACGT
TGGGCTCATTCGTCTCGGTGCTCAGGGTACTGGGGCGCGCGGATTGGCTGGCCACTCTCAAACCGCCCGTGACCATCAAC
CCGCTAGACATGCTGCGCCAAGTCGAGCAGCGCCAACGCGCGAGCAAGCCCCACGGCGTCAACCGCAAGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L1PP22

Antitoxin

Source ID Structure
AlphaFold DB A0A1L1PS24

References