Detailed information of TA system TA066466

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 4137566..4138243
• Replicon: chromosome
• Accession: NZ_CP017311
• Organism: Hydrogenophaga sp. PBC

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: Q5W_RS19705
• Protein ID: WP_050980552.1
• Coordinates: 4137854..4138243 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1L1PXQ1
• Locus tag: Q5W_RS19700
• Protein ID: WP_009515028.1
• Coordinates: 4137566..4137817 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Q5W_RS19675	4133144..4134058	+	915	WP_003050256.1	AAA family ATPase	-
Q5W_RS19680	4134055..4134525	+	471	WP_003090160.1	hypothetical protein	-
Q5W_RS25430	4134522..4134683	+	162	Protein_3945	HORMA domain containing protein	-
Q5W_RS19685	4134742..4135434	-	693	WP_009520510.1	IS6 family transposase	-
Q5W_RS19690	4135545..4136300	+	756	WP_084463011.1	LysR family transcriptional regulator	-
Q5W_RS19695	4136392..4137474	+	1083	WP_009515030.1	TRAP transporter substrate-binding protein DctP	-
Q5W_RS19700	4137566..4137817	+	252	WP_009515028.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
Q5W_RS19705	4137854..4138243	+	390	WP_050980552.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Q5W_RS19710	4138248..4139171	+	924	WP_009515023.1	delta(1)-pyrroline-2-carboxylate reductase family protein	-
Q5W_RS19715	4139168..4139890	+	723	WP_009515021.1	aldolase	-
Q5W_RS19720	4139898..4140887	-	990	WP_009515020.1	2Fe-2S iron-sulfur cluster binding domain-containing protein	-
Q5W_RS19725	4140909..4141874	-	966	WP_009515014.1	4-hydroxythreonine-4-phosphate dehydrogenase PdxA	-
Q5W_RS19730	4141891..4142355	-	465	WP_009515012.1	nuclear transport factor 2 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (11-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-78)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14441.69 Da
• Isoelectric Point: 10.6442

>T66466 WP_050980552.1 NZ_CP017311:4137854-4138243 [Hydrogenophaga sp. PBC]
VAAPSPHKYKLKFLPSALDEWKALDGSVKENFRKLLKSRLDNPHVPGAELRGELRGYYKIKLRKQGYRLVYGVEDDALVV
MVMAVDKREDSEAYASAIARLQPASKRIAKAGSGDAAPQKHTRPGKRRQ

Nucleotide

• Length: 390 bp

>T66466 NZ_CP017311:4137854-4138243 [Hydrogenophaga sp. PBC]
GTGGCAGCGCCCTCGCCACACAAGTACAAGCTGAAGTTCCTGCCCTCCGCGCTGGACGAATGGAAGGCCCTGGATGGATC
CGTGAAGGAGAACTTCAGGAAGCTGTTGAAATCGCGGCTGGACAATCCGCATGTGCCTGGCGCCGAGCTTCGGGGCGAAC
TCCGCGGTTACTACAAGATCAAGCTGCGCAAGCAGGGCTATCGCCTGGTGTATGGCGTGGAGGACGACGCACTCGTCGTG
ATGGTCATGGCCGTCGACAAACGAGAAGATTCCGAGGCCTACGCATCGGCCATCGCTCGCTTGCAGCCGGCCAGCAAACG
AATCGCGAAAGCGGGTTCTGGCGACGCGGCACCGCAGAAGCACACACGCCCGGGCAAACGACGTCAGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9193.71 Da
• Isoelectric Point: 5.6726

>AT66466 WP_009515028.1 NZ_CP017311:4137566-4137817 [Hydrogenophaga sp. PBC]
MNTILADQTVSMSDFKKNPAAVLRGAKHKPVAVLSHNRPAFYMLKPSLFEAIMEELIDQELQAKVAARLAEKIEAVEVDI
DSV

Nucleotide

• Length: 252 bp

>AT66466 NZ_CP017311:4137566-4137817 [Hydrogenophaga sp. PBC]
ATGAACACCATTCTCGCCGACCAAACCGTGAGCATGTCGGACTTCAAGAAGAACCCCGCGGCCGTCTTGCGTGGGGCAAA
GCACAAACCCGTGGCCGTGCTCAGCCACAACCGACCGGCTTTCTACATGCTCAAGCCCAGCCTTTTCGAGGCCATCATGG
AAGAACTGATCGATCAGGAGCTCCAGGCCAAGGTGGCTGCGCGGCTCGCGGAGAAGATCGAAGCTGTCGAAGTCGACATC
GACAGCGTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1L1PXQ1