Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 3561083..3562593 Replicon chromosome
Accession NZ_CP017311
Organism Hydrogenophaga sp. PBC

Toxin (Protein)


Gene name rlegT Uniprot ID A0A1L1PW87
Locus tag Q5W_RS16895 Protein ID WP_009519765.1
Coordinates 3561083..3561991 (-) Length 303 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID A0A1L1PU43
Locus tag Q5W_RS16900 Protein ID WP_009519763.1
Coordinates 3561988..3562593 (-) Length 202 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Q5W_RS16865 3556098..3556499 + 402 WP_035623344.1 DUF2784 domain-containing protein -
Q5W_RS16870 3556557..3557537 - 981 WP_009516340.1 amidohydrolase family protein -
Q5W_RS16875 3557673..3558650 + 978 WP_009516339.1 Bug family tripartite tricarboxylate transporter substrate binding protein -
Q5W_RS16885 3559128..3560362 + 1235 WP_148663157.1 IS3 family transposase -
Q5W_RS25340 3560591..3560977 + 387 WP_158515845.1 HNH endonuclease -
Q5W_RS16895 3561083..3561991 - 909 WP_009519765.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
Q5W_RS16900 3561988..3562593 - 606 WP_009519763.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
Q5W_RS16905 3562667..3563038 - 372 WP_069902985.1 hypothetical protein -
Q5W_RS16910 3563221..3565449 + 2229 WP_084462976.1 magnesium-translocating P-type ATPase -
Q5W_RS26170 3565407..3565769 + 363 WP_009519760.1 cation transporting ATPase C-terminal domain-containing protein -
Q5W_RS16915 3565789..3566244 - 456 WP_035622605.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-257)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(7-54)


Sequences

Toxin        


Download         Length: 303 a.a.        Molecular weight: 33673.39 Da        Isoelectric Point: 6.9221

>T66464 WP_009519765.1 NZ_CP017311:c3561991-3561083 [Hydrogenophaga sp. PBC]
VNHRRSPASLLARLLDRAKQGGEDYSLVLNRFGLERLLDRLAHSRHADRFLLKGALLFSLWYDQPHRPTRDADLLAFGPD
DVEHLTATFREIATIELDDGIVFDAESIRADPIREHNAYGGIRVRLVGRIGTTRCSLQVDVGFGDAVTPDPELVAYPPLL
PDFDAPRLRVYPVYTVIAEKYQAMVTLGAANSRMKDFHDIATIARRTSLDGATLARAIAATFERRRTELPAEPPLALQSA
FADDEAKQRQWAAFLARNRLGAFGLREVIALLYTLLWPATQIAASGSAATALWWPEHLAWTP

Download         Length: 909 bp

>T66464 NZ_CP017311:c3561991-3561083 [Hydrogenophaga sp. PBC]
GTGAATCATCGACGAAGTCCCGCGTCCCTGCTGGCGCGTTTGCTTGACAGGGCCAAGCAGGGCGGCGAGGACTACAGCCT
GGTGCTCAACCGCTTCGGGCTGGAGCGGCTGCTTGATCGCCTGGCCCATTCGCGGCATGCCGATCGGTTTCTCCTCAAAG
GGGCTTTGCTGTTCTCGCTGTGGTACGACCAGCCGCATCGCCCCACGCGAGACGCCGACCTGCTGGCCTTCGGTCCCGAC
GATGTTGAGCACTTGACGGCGACGTTTCGAGAAATTGCAACCATCGAACTCGATGACGGGATCGTGTTCGATGCCGAGTC
GATTCGCGCTGATCCGATCCGCGAGCACAACGCCTACGGAGGCATTCGTGTGCGGCTGGTCGGCCGCATTGGCACTACCC
GCTGTTCGCTTCAAGTGGATGTGGGGTTTGGCGATGCCGTCACGCCGGACCCCGAGCTTGTTGCCTACCCGCCTCTACTA
CCCGACTTCGACGCGCCCCGGCTCCGGGTCTATCCCGTCTACACCGTGATCGCAGAGAAATACCAAGCCATGGTCACGCT
GGGCGCCGCGAACAGCCGCATGAAGGACTTCCATGACATCGCGACGATCGCGCGAAGAACGTCGCTTGATGGTGCGACCC
TGGCACGCGCCATTGCCGCCACGTTTGAGCGCCGACGCACGGAGTTGCCGGCGGAGCCGCCACTGGCGCTGCAATCGGCG
TTTGCTGACGACGAGGCGAAGCAGCGGCAATGGGCAGCGTTCCTTGCCAGGAATCGGTTGGGGGCATTCGGCTTGCGCGA
AGTGATTGCACTGCTCTATACGCTGTTGTGGCCTGCGACGCAGATAGCTGCGTCGGGGTCAGCGGCTACGGCGCTGTGGT
GGCCAGAGCACTTAGCGTGGACACCCTGA

Antitoxin


Download         Length: 202 a.a.        Molecular weight: 22468.16 Da        Isoelectric Point: 8.7040

>AT66464 WP_009519763.1 NZ_CP017311:c3562593-3561988 [Hydrogenophaga sp. PBC]
VLPSDTDRLLELAASRRLLRGADARDIGVSPQLLIKLQQAGRLVRVARGVYSLPDAPLTEHQSLVEVCRRVPKAVICLLS
ALRFHELGSQAPHEVWLALPEGVRSPSVDYPALRIVRLRDAAYSEGIETVMDEGAPIRVYGVAKTISDCFKFRHKIGLDV
ALEALKDAWQRRLVSMDELTHFARINRVERVMLPYLEALTA

Download         Length: 606 bp

>AT66464 NZ_CP017311:c3562593-3561988 [Hydrogenophaga sp. PBC]
GTGCTTCCCAGCGACACGGACCGTCTTCTTGAGCTTGCGGCCAGCAGGCGGCTGCTGCGTGGTGCGGACGCGCGCGACAT
CGGCGTGTCGCCGCAGCTACTGATCAAGCTGCAGCAGGCCGGGCGACTGGTTCGTGTGGCCAGGGGCGTATACAGCCTGC
CCGATGCGCCCCTCACAGAGCACCAATCGCTTGTTGAAGTCTGCCGGCGCGTACCCAAGGCGGTGATCTGCCTGCTGTCG
GCACTGCGCTTTCACGAGCTGGGGTCGCAAGCGCCACACGAGGTGTGGCTGGCGCTGCCGGAGGGGGTGCGTTCACCGTC
CGTGGACTACCCCGCGCTGCGCATCGTGCGGCTGCGCGATGCCGCCTACAGCGAAGGTATCGAAACCGTGATGGATGAAG
GTGCCCCGATTCGCGTGTACGGCGTGGCCAAGACAATCTCCGACTGCTTCAAGTTTCGCCACAAGATCGGTCTCGACGTG
GCGCTGGAAGCGCTTAAGGACGCTTGGCAACGGCGGCTGGTGTCCATGGACGAACTGACGCATTTCGCGCGCATCAATCG
GGTGGAGCGCGTAATGCTGCCCTACCTGGAAGCATTGACGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L1PW87

Antitoxin

Source ID Structure
AlphaFold DB A0A1L1PU43

References