Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3463695..3464335 Replicon chromosome
Accession NZ_CP017296
Organism Pseudomonas fluorescens strain Pt14

Toxin (Protein)


Gene name vagD Uniprot ID A0A0W0MYI4
Locus tag BH711_RS15510 Protein ID WP_014719602.1
Coordinates 3463695..3464108 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A0W0MYL2
Locus tag BH711_RS15515 Protein ID WP_014719603.1
Coordinates 3464105..3464335 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BH711_RS15495 3459453..3460238 - 786 WP_020302951.1 ABC transporter substrate-binding protein -
BH711_RS15500 3460935..3462890 - 1956 WP_005790645.1 acetate--CoA ligase -
BH711_RS15505 3463288..3463557 + 270 WP_014719601.1 DUF2790 domain-containing protein -
BH711_RS15510 3463695..3464108 - 414 WP_014719602.1 type II toxin-antitoxin system VapC family toxin Toxin
BH711_RS15515 3464105..3464335 - 231 WP_014719603.1 virulence factor Antitoxin
BH711_RS15520 3464816..3466066 + 1251 WP_014719604.1 ribonucleotide-diphosphate reductase subunit beta -
BH711_RS26695 3466133..3466306 + 174 Protein_3072 HNH endonuclease -
BH711_RS15525 3466379..3467026 + 648 WP_020303103.1 HAD-IB family hydrolase -
BH711_RS15530 3467118..3468077 - 960 WP_014719606.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15188.53 Da        Isoelectric Point: 7.6998

>T66440 WP_014719602.1 NZ_CP017296:c3464108-3463695 [Pseudomonas fluorescens]
VTTYMLDTCICSFIMRERPECVLKRLALEVARSNRIVISAITYAEMRYGQIGKKASSKHKTLVDEFVKRLDEVLPWGVAA
VDATVEVKRSLTEQGAIIGQNDTAIAGHAIASGCTLVTNNIREFSRVAGLSYEDWVH

Download         Length: 414 bp

>T66440 NZ_CP017296:c3464108-3463695 [Pseudomonas fluorescens]
GTGACGACATACATGCTGGATACCTGCATTTGCTCGTTCATCATGCGTGAGCGGCCCGAGTGCGTGCTTAAGCGTCTGGC
CTTGGAGGTGGCGAGGAGCAATCGAATCGTGATTTCGGCCATAACCTATGCCGAAATGCGATATGGACAGATTGGGAAAA
AGGCATCGTCCAAACACAAGACGTTAGTCGATGAGTTTGTGAAGCGACTCGATGAAGTGTTGCCTTGGGGCGTGGCGGCG
GTGGACGCGACGGTTGAGGTGAAGCGAAGCCTGACCGAGCAAGGGGCGATCATCGGCCAAAATGATACTGCTATTGCAGG
GCATGCAATTGCTTCGGGGTGTACGTTGGTGACCAACAATATTCGGGAGTTCAGTCGCGTAGCGGGGTTGTCTTACGAGG
ATTGGGTCCATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8654.65 Da        Isoelectric Point: 4.5557

>AT66440 WP_014719603.1 NZ_CP017296:c3464335-3464105 [Pseudomonas fluorescens]
MRTVSIFKNGKNQAIRFPNDMAYEGVGELEITRNGDTITLRPVRPSWGSLSELPRADEDFLQERQDVVGDEGRFNL

Download         Length: 231 bp

>AT66440 NZ_CP017296:c3464335-3464105 [Pseudomonas fluorescens]
ATGCGCACAGTCTCAATTTTTAAAAATGGAAAGAACCAGGCTATTCGATTTCCAAACGACATGGCCTATGAGGGAGTCGG
TGAGCTCGAAATCACCCGCAATGGAGATACGATTACATTACGACCTGTCCGACCTAGCTGGGGGTCGCTGAGTGAGTTAC
CCAGGGCGGACGAAGATTTTCTTCAGGAGCGTCAGGACGTTGTTGGCGATGAAGGCAGGTTCAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W0MYI4

Antitoxin

Source ID Structure
AlphaFold DB A0A0W0MYL2

References