Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 2370423..2371036 Replicon chromosome
Accession NZ_CP017296
Organism Pseudomonas fluorescens strain Pt14

Toxin (Protein)


Gene name hicA Uniprot ID A0A0W0N4L4
Locus tag BH711_RS10245 Protein ID WP_014718823.1
Coordinates 2370423..2370674 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A854B833
Locus tag BH711_RS10250 Protein ID WP_014718824.1
Coordinates 2370671..2371036 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BH711_RS10245 2370423..2370674 + 252 WP_014718823.1 type II toxin-antitoxin system HicA family toxin Toxin
BH711_RS10250 2370671..2371036 + 366 WP_014718824.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BH711_RS10255 2371037..2372209 - 1173 WP_014718825.1 MFS transporter -
BH711_RS10260 2372342..2372929 + 588 WP_038450459.1 TetR/AcrR family transcriptional regulator -
BH711_RS10265 2372913..2374268 - 1356 WP_038450461.1 MATE family efflux transporter -
BH711_RS10270 2374349..2375179 - 831 WP_019816829.1 IclR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9526.11 Da        Isoelectric Point: 10.0459

>T66438 WP_014718823.1 NZ_CP017296:2370423-2370674 [Pseudomonas fluorescens]
VSKNEKLLAKLLNEHMAFTWSELVTLLRRLGYTQIEGAGSRVKFDMGDPSAMITLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Download         Length: 252 bp

>T66438 NZ_CP017296:2370423-2370674 [Pseudomonas fluorescens]
GTGTCCAAGAATGAAAAGCTGCTCGCCAAACTGCTCAATGAGCACATGGCATTTACCTGGTCTGAGCTCGTCACGTTATT
ACGCCGATTGGGATACACACAGATTGAAGGGGCCGGAAGCCGGGTCAAGTTCGACATGGGCGACCCCAGTGCAATGATCA
CCCTGCACAAGCCTCACCCCGGCAACGAACTGAAACACTACATTCGGCGCCAGATCATCGAACAATTGAAATCAGGAGAA
CTGATTCAGTGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13248.12 Da        Isoelectric Point: 7.3725

>AT66438 WP_014718824.1 NZ_CP017296:2370671-2371036 [Pseudomonas fluorescens]
VNNQLKHKGYIGSIEASLEDNCLFGKILFIKALVSYEGKTVAELDAAFRGAVDDYLATCQSLGHTPEKPCKGSFNVRVGH
DLHLAAALAANRKKVTLNDLTRQALNEFLQHHYPEPCPTIG

Download         Length: 366 bp

>AT66438 NZ_CP017296:2370671-2371036 [Pseudomonas fluorescens]
GTGAACAACCAACTGAAACACAAAGGCTACATCGGCTCCATCGAAGCCAGCCTCGAGGACAACTGCCTGTTTGGTAAAAT
CCTGTTCATCAAGGCATTGGTGAGCTATGAAGGCAAAACTGTGGCTGAACTGGACGCAGCCTTCCGTGGCGCGGTGGATG
ATTATCTCGCTACCTGCCAGAGCCTGGGGCACACGCCGGAGAAACCGTGCAAAGGTTCATTCAACGTACGTGTCGGGCAT
GACTTGCATTTGGCCGCTGCCCTGGCGGCAAACCGTAAGAAAGTGACATTGAATGATCTCACGCGTCAGGCGCTGAACGA
ATTTCTGCAGCATCATTACCCAGAGCCATGCCCGACGATTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W0N4L4

Antitoxin

Source ID Structure
AlphaFold DB A0A854B833

References