Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 572869..574112 Replicon chromosome
Accession NZ_CP017295
Organism Streptococcus gordonii strain IE35

Toxin (Protein)


Gene name sezT Uniprot ID A0A1V0H0B3
Locus tag WH25_RS02785 Protein ID WP_046165029.1
Coordinates 573345..574112 (+) Length 256 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID A0A6I3P6W1
Locus tag WH25_RS02780 Protein ID WP_046165028.1
Coordinates 572869..573345 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WH25_RS02765 568162..569019 + 858 WP_008808388.1 ABC transporter ATP-binding protein -
WH25_RS02770 569000..569653 + 654 WP_000677415.1 ABC-2 transporter permease -
WH25_RS10795 569667..569834 + 168 WP_020992799.1 hypothetical protein -
WH25_RS02775 570696..572213 - 1518 WP_046165027.1 ABC transporter ATP-binding protein/permease -
WH25_RS10615 572197..572719 - 523 Protein_539 SPASM domain-containing protein -
WH25_RS02780 572869..573345 + 477 WP_046165028.1 helix-turn-helix domain-containing protein Antitoxin
WH25_RS02785 573345..574112 + 768 WP_046165029.1 zeta toxin family protein Toxin
WH25_RS02790 574380..574637 + 258 WP_046165030.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
WH25_RS02795 574634..575005 + 372 WP_046165031.1 type II toxin-antitoxin system death-on-curing family toxin -
WH25_RS02800 575694..576650 + 957 WP_046165032.1 hypothetical protein -
WH25_RS10625 576693..576821 + 129 WP_081325072.1 conjugal transfer protein TraX -
WH25_RS02805 576974..577177 - 204 WP_008808393.1 CsbD family protein -
WH25_RS02810 577359..577991 - 633 WP_172455857.1 DUF421 domain-containing protein -
WH25_RS02815 577988..578440 - 453 WP_045634319.1 DUF3290 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 564797..579918 15121


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(26-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 29212.13 Da        Isoelectric Point: 6.8457

>T66434 WP_046165029.1 NZ_CP017295:573345-574112 [Streptococcus gordonii]
MKLEEFSQDDFERASRRLVRSLTRGKTTSSQPKAILLGGQSGAGKTTIHRIKQREFQGNIIIIDGDSYRSFHPNYLGLQE
KYGKDSVDYTKVFAGQMVEYLVDELSKQGYHLLIEGTLRTTEVPRKTAQLLITKGYQVSLALIATKPELSYLSTLIRYEE
LYAIDSSQARATPKAHHDGIVEHMVDNLRELENDKLFRQIQIYQRDQSCVYDSQVDETSATEVLHECLFGKWSKVEEEML
KLGQERLREMGGINK

Download         Length: 768 bp

>T66434 NZ_CP017295:573345-574112 [Streptococcus gordonii]
ATGAAACTAGAAGAATTTAGTCAAGATGATTTTGAACGAGCATCCAGACGACTCGTTCGTTCTTTAACTCGTGGTAAAAC
AACTTCGTCTCAGCCCAAGGCTATCTTGCTAGGTGGACAGAGTGGTGCTGGGAAAACAACGATTCATCGTATTAAACAAA
GGGAATTTCAAGGTAATATCATTATCATTGATGGAGATAGTTATCGCTCTTTTCATCCGAACTACCTTGGCTTACAGGAA
AAGTATGGAAAAGATAGTGTGGATTATACCAAAGTATTCGCGGGACAAATGGTTGAATATCTCGTAGATGAATTGAGTAA
ACAAGGTTATCATTTGTTAATCGAGGGCACCTTGAGAACAACAGAAGTTCCTAGAAAAACGGCACAATTATTGATAACTA
AAGGATATCAAGTCTCACTTGCACTAATAGCGACCAAGCCAGAATTGTCCTATCTCAGTACTTTGATACGTTATGAGGAG
CTCTACGCCATAGATTCTAGTCAAGCTAGAGCAACTCCTAAAGCACACCATGATGGAATTGTAGAACATATGGTTGATAA
CTTACGGGAGTTAGAAAATGATAAACTTTTTAGACAAATTCAAATTTATCAAAGAGATCAATCGTGTGTTTATGATTCGC
AAGTAGACGAAACCTCAGCAACAGAAGTTCTACACGAATGCCTATTTGGAAAATGGAGTAAGGTGGAGGAAGAGATGTTG
AAGTTGGGACAGGAACGGTTGAGAGAGATGGGGGGAATTAATAAGTGA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18054.48 Da        Isoelectric Point: 4.3745

>AT66434 WP_046165028.1 NZ_CP017295:572869-573345 [Streptococcus gordonii]
MIGENIKALRKTHDLTQPEFAKIVGISRNSLSRYENGTSSISTELIDRICQKFNVSYIDIVGEEKMLTPVEDYQLTLKIE
VIKERGANILAQLYRFQDEQGIAFDDTSNPWVLMSDDLSDLLNTKIYLVGTFDEVERYNGYLDGIERMLEQATHLVVA

Download         Length: 477 bp

>AT66434 NZ_CP017295:572869-573345 [Streptococcus gordonii]
ATGATAGGAGAAAATATTAAAGCGTTACGTAAAACACATGATCTAACCCAGCCTGAGTTCGCAAAGATTGTTGGTATCTC
TCGAAATAGCCTAAGTCGTTATGAAAACGGGACAAGTTCAATTTCGACAGAATTAATAGATCGTATTTGTCAGAAATTTA
ATGTTTCCTATATCGATATTGTAGGAGAGGAAAAGATGCTCACGCCAGTGGAAGATTACCAGCTCACTCTGAAAATTGAA
GTGATTAAAGAACGAGGGGCGAATATCTTAGCGCAACTTTATCGTTTTCAAGATGAACAAGGAATTGCATTTGATGATAC
TTCTAATCCTTGGGTTCTAATGAGCGATGATTTGTCTGATTTGCTGAACACGAAGATTTATCTTGTGGGGACTTTTGATG
AAGTAGAGCGATATAATGGCTATTTGGATGGCATTGAACGGATGCTAGAACAAGCTACTCATCTGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1V0H0B3

Antitoxin

Source ID Structure
AlphaFold DB A0A6I3P6W1

References