66433

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 364135..364672 Replicon plasmid unnamed1
Accession NZ_CP017294
Organism Pseudomonas aeruginosa strain PA83

Toxin (Protein)


Gene name relE Uniprot ID A0A2T1A3Q3
Locus tag PSA83_RS34320 Protein ID WP_017518825.1
Coordinates 364135..364416 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2T1A3N8
Locus tag PSA83_RS34325 Protein ID WP_017518824.1
Coordinates 364403..364672 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSA83_RS34300 359143..360720 + 1578 WP_033958613.1 PAS domain-containing methyl-accepting chemotaxis protein -
PSA83_RS34305 361535..361750 + 216 WP_088922561.1 hypothetical protein -
PSA83_RS34310 362373..363302 - 930 WP_003150544.1 recombinase family protein -
PSA83_RS34315 363433..364008 - 576 WP_001173919.1 recombinase family protein -
PSA83_RS34320 364135..364416 - 282 WP_017518825.1 type II toxin-antitoxin system YafQ family toxin Toxin
PSA83_RS34325 364403..364672 - 270 WP_017518824.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PSA83_RS34330 364988..365227 + 240 WP_003089107.1 ribbon-helix-helix domain-containing protein -
PSA83_RS34335 365227..365637 + 411 WP_003150546.1 putative toxin-antitoxin system toxin component, PIN family -
PSA83_RS34340 365641..368634 + 2994 WP_003089110.1 Tn3 family transposase -
PSA83_RS34345 368647..368859 - 213 WP_003089113.1 hypothetical protein -
PSA83_RS34350 368867..369142 - 276 WP_003150552.1 mercury resistance system periplasmic binding protein MerP -
PSA83_RS34355 369155..369505 - 351 WP_003089115.1 mercury transporter MerT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..398087 398087
- inside IScluster/Tn - - 354448..368634 14186


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(8-82)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10707.15 Da        Isoelectric Point: 8.9188

>T66433 WP_017518825.1 NZ_CP017294:c364416-364135 [Pseudomonas aeruginosa]
MRTIDRSSAFKRDYKREAKGQHRATLDDALKPVLVALATDQPLDARYRDHDLSGDWAGYRECHIKPDLLLIYRKSDPDIL
RLARLGSHSELFG

Download         Length: 282 bp

>T66433 NZ_CP017294:c364416-364135 [Pseudomonas aeruginosa]
ATGCGGACGATTGACCGTTCCTCCGCGTTCAAACGCGATTACAAGCGCGAGGCCAAGGGCCAGCACCGCGCCACGCTCGA
TGACGCGCTCAAGCCGGTATTGGTCGCGCTGGCGACCGATCAGCCCCTCGATGCGCGCTACCGCGATCACGACCTTTCCG
GCGATTGGGCGGGCTACCGTGAATGCCACATCAAGCCCGACCTGCTGCTGATCTACCGCAAGTCCGATCCCGACATCCTG
CGCCTGGCGCGGCTTGGCTCGCACAGCGAGCTTTTCGGCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9719.10 Da        Isoelectric Point: 5.6976

>AT66433 WP_017518824.1 NZ_CP017294:c364672-364403 [Pseudomonas aeruginosa]
MSTTADTYVRARIDTNTKERAASALEAMGLSISDAIRLLMLRIADEHRLPFDVKVPNATTKKAIAELEAGKGKKFTSVDD
LMADLHADD

Download         Length: 270 bp

>AT66433 NZ_CP017294:c364672-364403 [Pseudomonas aeruginosa]
ATGAGTACCACTGCCGACACCTACGTCCGCGCCCGCATCGACACCAACACCAAGGAGCGTGCCGCCAGCGCGCTCGAAGC
AATGGGGTTGTCGATTTCCGACGCCATCCGCCTGCTGATGCTGCGCATCGCCGACGAACACCGCCTGCCCTTCGATGTGA
AGGTGCCCAATGCCACCACCAAGAAGGCCATTGCCGAACTGGAAGCGGGCAAGGGCAAGAAGTTCACCAGCGTGGACGAT
CTGATGGCGGATTTGCATGCGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T1A3Q3

Antitoxin

Source ID Structure
AlphaFold DB A0A2T1A3N8

References