Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4750505..4751162 Replicon chromosome
Accession NZ_CP017289
Organism Klebsiella variicola strain GJ3

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag BBD65_RS25495 Protein ID WP_002916310.1
Coordinates 4750505..4750915 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag BBD65_RS25500 Protein ID WP_002916312.1
Coordinates 4750896..4751162 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBD65_RS25475 4746505..4748238 - 1734 WP_064166671.1 single-stranded-DNA-specific exonuclease RecJ -
BBD65_RS25480 4748244..4748957 - 714 WP_077139430.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BBD65_RS25485 4748980..4749876 - 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
BBD65_RS25490 4749977..4750498 + 522 WP_008806427.1 flavodoxin FldB -
BBD65_RS25495 4750505..4750915 - 411 WP_002916310.1 protein YgfX Toxin
BBD65_RS25500 4750896..4751162 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
BBD65_RS25505 4751408..4752391 + 984 WP_032733797.1 tRNA-modifying protein YgfZ -
BBD65_RS25510 4752599..4753258 - 660 WP_008806429.1 hemolysin III family protein -
BBD65_RS25515 4753422..4753733 - 312 WP_008806430.1 N(4)-acetylcytidine aminohydrolase -
BBD65_RS25520 4753784..4754512 + 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
BBD65_RS25525 4754632..4756065 + 1434 WP_063105732.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T66416 WP_002916310.1 NZ_CP017289:c4750915-4750505 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T66416 NZ_CP017289:c4750915-4750505 [Klebsiella variicola]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGTTGGTTCCCTGGCCGCTAAGCTACACCCCGATCTGGCTGCTGCTGTTGTCGCTGGTAGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGAGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTCATCAATAGCGGTATGCTGCTGCGTTTACGCCATGTCGATACCCGGCGCGG
GCAGCATCTGTGGCTGGCGGCGGATAGCATGGATGCCGGAGAATGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT66416 WP_002916312.1 NZ_CP017289:c4751162-4750896 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT66416 NZ_CP017289:c4751162-4750896 [Klebsiella variicola]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAACGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References