Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4751295..4751952 Replicon chromosome
Accession NZ_CP017284
Organism Klebsiella variicola strain GJ1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag BBD63_RS24985 Protein ID WP_002916310.1
Coordinates 4751295..4751705 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag BBD63_RS24990 Protein ID WP_002916312.1
Coordinates 4751686..4751952 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBD63_RS24965 4747295..4749028 - 1734 WP_064166671.1 single-stranded-DNA-specific exonuclease RecJ -
BBD63_RS24970 4749034..4749747 - 714 WP_077139430.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BBD63_RS24975 4749770..4750666 - 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
BBD63_RS24980 4750767..4751288 + 522 WP_008806427.1 flavodoxin FldB -
BBD63_RS24985 4751295..4751705 - 411 WP_002916310.1 protein YgfX Toxin
BBD63_RS24990 4751686..4751952 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
BBD63_RS24995 4752198..4753181 + 984 WP_032733797.1 tRNA-modifying protein YgfZ -
BBD63_RS25000 4753389..4754048 - 660 WP_008806429.1 hemolysin III family protein -
BBD63_RS25005 4754212..4754523 - 312 WP_008806430.1 N(4)-acetylcytidine aminohydrolase -
BBD63_RS25010 4754574..4755302 + 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
BBD63_RS25015 4755422..4756855 + 1434 WP_063105732.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T66392 WP_002916310.1 NZ_CP017284:c4751705-4751295 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T66392 NZ_CP017284:c4751705-4751295 [Klebsiella variicola]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGTTGGTTCCCTGGCCGCTAAGCTACACCCCGATCTGGCTGCTGCTGTTGTCGCTGGTAGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGAGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTCATCAATAGCGGTATGCTGCTGCGTTTACGCCATGTCGATACCCGGCGCGG
GCAGCATCTGTGGCTGGCGGCGGATAGCATGGATGCCGGAGAATGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT66392 WP_002916312.1 NZ_CP017284:c4751952-4751686 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT66392 NZ_CP017284:c4751952-4751686 [Klebsiella variicola]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAACGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References