Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4524964..4525621 Replicon chromosome
Accession NZ_CP017279
Organism Enterobacter ludwigii strain EN-119

Toxin (Protein)


Gene name cptA Uniprot ID G8LDB6
Locus tag BH714_RS21295 Protein ID WP_014171514.1
Coordinates 4525211..4525621 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag BH714_RS21290 Protein ID WP_003863437.1
Coordinates 4524964..4525230 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BH714_RS21270 4520371..4521804 - 1434 WP_020883728.1 6-phospho-beta-glucosidase BglA -
BH714_RS21275 4521921..4522652 - 732 WP_040018863.1 MurR/RpiR family transcriptional regulator -
BH714_RS21280 4522919..4523578 + 660 WP_014171517.1 hemolysin III family protein -
BH714_RS21285 4523689..4524669 - 981 WP_040018864.1 tRNA-modifying protein YgfZ -
BH714_RS21290 4524964..4525230 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
BH714_RS21295 4525211..4525621 + 411 WP_014171514.1 protein YgfX Toxin
BH714_RS21300 4525628..4526149 - 522 WP_014171513.1 flavodoxin FldB -
BH714_RS21305 4526251..4527147 + 897 WP_014171511.1 site-specific tyrosine recombinase XerD -
BH714_RS21310 4527171..4527884 + 714 WP_020883731.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BH714_RS21315 4527890..4529623 + 1734 WP_040018865.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16217.15 Da        Isoelectric Point: 11.5020

>T66373 WP_014171514.1 NZ_CP017279:4525211-4525621 [Enterobacter ludwigii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRIHARQGEIKLLMDSRLRWQGK
EWEILGMPWMIASGMMLRLRSVDSGRRQHLWLAADSMDSAEWRDLRRMLLQQLTQE

Download         Length: 411 bp

>T66373 NZ_CP017279:4525211-4525621 [Enterobacter ludwigii]
GTGGTCCTGTGGCAATCTGACCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTGTTGCTCCACGGCCTGGTCGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTTAGCTATACGCCTCTGTGGCTGCTGTTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGCCGCATTCATGCCCGTCAGGGGGAGATCAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATTCTCGGTATGCCCTGGATGATCGCTTCCGGCATGATGCTGCGGCTACGTAGCGTGGACAGCGGGCGTCG
CCAGCATCTGTGGCTGGCCGCGGACAGTATGGATAGCGCTGAGTGGCGGGACCTGCGTCGGATGTTATTACAACAGCTGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT66373 WP_003863437.1 NZ_CP017279:4524964-4525230 [Enterobacter ludwigii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT66373 NZ_CP017279:4524964-4525230 [Enterobacter ludwigii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCTGATT
TATTTAACTGGCTGATGAATCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BUV6

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References