Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 3699414..3700072 Replicon chromosome
Accession NZ_CP017279
Organism Enterobacter ludwigii strain EN-119

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag BH714_RS17380 Protein ID WP_032681769.1
Coordinates 3699731..3700072 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag BH714_RS17375 Protein ID WP_140418747.1
Coordinates 3699414..3699710 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BH714_RS17340 3694520..3695395 + 876 WP_032681774.1 GTPase family protein -
BH714_RS17345 3695639..3696355 + 717 WP_012543038.1 WYL domain-containing protein -
BH714_RS17350 3696391..3696843 + 453 WP_032682060.1 hypothetical protein -
BH714_RS17355 3696915..3697388 + 474 WP_040018519.1 hypothetical protein -
BH714_RS17360 3697508..3698329 + 822 WP_021571974.1 DUF945 domain-containing protein -
BH714_RS17365 3698360..3698803 + 444 WP_032681771.1 antirestriction protein -
BH714_RS17370 3698816..3699358 + 543 WP_040018523.1 DNA repair protein RadC -
BH714_RS17375 3699414..3699710 + 297 WP_140418747.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BH714_RS17380 3699731..3700072 + 342 WP_032681769.1 TA system toxin CbtA family protein Toxin
BH714_RS17385 3700331..3701338 + 1008 WP_032681768.1 restriction endonuclease -
BH714_RS17390 3701519..3702394 - 876 WP_040018525.1 HNH endonuclease -
BH714_RS23830 3702695..3703147 + 453 WP_074147066.1 type I toxin-antitoxin system SymE family toxin -
BH714_RS17400 3703243..3703989 - 747 WP_040018526.1 class I SAM-dependent methyltransferase -
BH714_RS17405 3704000..3704257 - 258 WP_014168433.1 YjhX family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3631477..3708096 76619


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(2-96)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12732.76 Da        Isoelectric Point: 8.9919

>T66372 WP_032681769.1 NZ_CP017279:3699731-3700072 [Enterobacter ludwigii]
MKTLPATTPQAATLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDEKVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
DWLEQSPYLRAVDILRARQATGLLKRNRISAAR

Download         Length: 342 bp

>T66372 NZ_CP017279:3699731-3700072 [Enterobacter ludwigii]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGCGACGCTATGTCTGTCGCCTGTGGCAGTCTGGCAAATGCTGCTTGC
TCGCCTGCTGGAACAACATTATGGCCTGACGCTAAACGACACGCCGTTCAGTGATGAAAAGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTAGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
GACTGGCTAGAACAGTCCCCATATCTGCGGGCAGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10956.49 Da        Isoelectric Point: 6.7287

>AT66372 WP_140418747.1 NZ_CP017279:3699414-3699710 [Enterobacter ludwigii]
MNRNVTPCFGARLVQEGNRLHYLADRASITGKFSEAECLKLDLAFPHFISQMESMLTTGEINPRHAHCVTLYHNGFTCEA
DTLGSCGYVYIAVYPTHC

Download         Length: 297 bp

>AT66372 NZ_CP017279:3699414-3699710 [Enterobacter ludwigii]
CTGAATCGTAATGTGACACCTTGCTTTGGCGCTCGTCTGGTACAGGAGGGAAACCGACTGCACTATCTGGCTGACCGGGC
CAGTATCACCGGTAAGTTCAGCGAAGCAGAATGTCTTAAGCTGGATTTGGCATTCCCGCATTTTATCAGCCAGATGGAAT
CGATGCTGACTACTGGTGAAATAAATCCTCGCCATGCCCACTGTGTCACCCTGTACCACAATGGTTTCACCTGCGAAGCC
GATACCCTTGGCAGTTGCGGCTACGTATACATCGCCGTTTACCCCACTCATTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References