Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 213959..214579 Replicon chromosome
Accession NZ_CP017279
Organism Enterobacter ludwigii strain EN-119

Toxin (Protein)


Gene name Hha Uniprot ID G8LPY2
Locus tag BH714_RS01025 Protein ID WP_014168902.1
Coordinates 213959..214177 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID W0BRV6
Locus tag BH714_RS01030 Protein ID WP_020885187.1
Coordinates 214205..214579 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BH714_RS00995 209970..210230 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
BH714_RS01000 210233..210373 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
BH714_RS01005 210370..211080 - 711 WP_014168897.1 GNAT family N-acetyltransferase -
BH714_RS01010 211181..212641 + 1461 WP_040016798.1 PLP-dependent aminotransferase family protein -
BH714_RS01015 212613..213080 - 468 WP_032677533.1 membrane protein -
BH714_RS01020 213198..213749 - 552 WP_020885188.1 maltose O-acetyltransferase -
BH714_RS01025 213959..214177 - 219 WP_014168902.1 hemolysin expression modulator Hha Toxin
BH714_RS01030 214205..214579 - 375 WP_020885187.1 Hha toxicity modulator TomB Antitoxin
BH714_RS01035 215091..218237 - 3147 WP_014168904.1 multidrug efflux RND transporter permease subunit -
BH714_RS01040 218260..219453 - 1194 WP_020885186.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8654.04 Da        Isoelectric Point: 8.9107

>T66362 WP_014168902.1 NZ_CP017279:c214177-213959 [Enterobacter ludwigii]
MSEKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWRFVR

Download         Length: 219 bp

>T66362 NZ_CP017279:c214177-213959 [Enterobacter ludwigii]
ATGTCTGAAAAACCACTCACAAAAATCGATTATTTGATGCGTTTGCGACGCTGTCAGTCAATAGACACGCTTGAACGTGT
AATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCGGCTGACCACCGTCTTGCAGAAC
TGACCATGAATAAGCTGTATGACAAAATCCCAACGTCCGTGTGGAGATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14495.31 Da        Isoelectric Point: 4.8886

>AT66362 WP_020885187.1 NZ_CP017279:c214579-214205 [Enterobacter ludwigii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFINVSRANPVSLSC

Download         Length: 375 bp

>AT66362 NZ_CP017279:c214579-214205 [Enterobacter ludwigii]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTAAACGAGTTGATCGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTGATTGAGCAAATTGATGAATACCTG
GATGACACCTTTATGTTGTTCAGCAGCTACGGCATTAATGCGCAAGATTTGCAGAAATGGCGTAAATCGGGCAACCGACT
ATTTCGTTGCTTCATCAACGTGAGCAGAGCTAACCCCGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BM33

Antitoxin

Source ID Structure
AlphaFold DB A0A5C1BX74

References