Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1311706..1312247 Replicon chromosome
Accession NZ_CP017260
Organism Formosa sp. Hel1_33_131

Toxin (Protein)


Gene name parE Uniprot ID A0A1D7XY81
Locus tag FORMB_RS05935 Protein ID WP_069676578.1
Coordinates 1311706..1312008 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1D7XY73
Locus tag FORMB_RS05940 Protein ID WP_069676579.1
Coordinates 1312005..1312247 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORMB_RS05910 1307538..1307933 + 396 WP_069676574.1 hypothetical protein -
FORMB_RS05915 1307936..1308937 - 1002 WP_069676575.1 glycerol-3-phosphate dehydrogenase -
FORMB_RS05920 1309004..1309780 - 777 WP_069676576.1 hypothetical protein -
FORMB_RS05925 1309938..1310585 + 648 WP_069676577.1 thymidine kinase -
FORMB_RS05930 1310578..1311687 + 1110 WP_069677914.1 alanine racemase -
FORMB_RS05935 1311706..1312008 - 303 WP_069676578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORMB_RS05940 1312005..1312247 - 243 WP_069676579.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FORMB_RS05945 1312461..1313447 + 987 WP_069676580.1 aspartate-semialdehyde dehydrogenase -
FORMB_RS05950 1313456..1314367 + 912 WP_069676581.1 ABC transporter ATP-binding protein -
FORMB_RS05955 1314463..1315392 + 930 WP_069676582.1 SPFH domain-containing protein -
FORMB_RS05960 1315544..1316437 - 894 WP_069676583.1 anti-sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-94)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 12355.43 Da        Isoelectric Point: 10.4559

>T66357 WP_069676578.1 NZ_CP017260:c1312008-1311706 [Formosa sp. Hel1_33_131]
MSTTKYRISKQAIEDLNARWIYTLRKWSKKQADRYYDLIIEEIEFIADNYLIGKPSEQTRKNYRVTKIKSHLIFYRKFEN
EIVEIVRILHQRMDVKKRLK

Download         Length: 303 bp

>T66357 NZ_CP017260:c1312008-1311706 [Formosa sp. Hel1_33_131]
ATGAGCACTACCAAATACCGAATTAGCAAACAAGCCATTGAGGATTTGAATGCGAGATGGATTTATACACTTCGTAAATG
GTCTAAAAAGCAAGCGGATCGATATTATGACTTGATAATCGAAGAGATTGAATTTATTGCTGATAACTATTTGATTGGAA
AACCGTCGGAGCAAACCAGAAAAAATTACAGAGTGACGAAAATTAAATCCCATCTAATTTTTTACAGAAAATTTGAAAAT
GAAATTGTTGAAATCGTCAGAATTCTACATCAAAGAATGGATGTAAAGAAACGATTGAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9154.13 Da        Isoelectric Point: 4.8615

>AT66357 WP_069676579.1 NZ_CP017260:c1312247-1312005 [Formosa sp. Hel1_33_131]
MGKNTSISLGNHFEEFINGEVKSGRYSSVSEVIRSALRMLESEDRKERELIKALEIGEQSGFVDDFDSNQNLTELHRQHL

Download         Length: 243 bp

>AT66357 NZ_CP017260:c1312247-1312005 [Formosa sp. Hel1_33_131]
ATGGGAAAAAACACATCCATATCACTCGGAAATCATTTTGAAGAATTTATAAATGGTGAAGTAAAATCTGGCAGGTACAG
TTCTGTAAGCGAGGTTATTCGTTCCGCATTACGAATGTTGGAATCAGAAGATAGAAAAGAAAGAGAATTGATTAAGGCTC
TTGAAATAGGAGAACAAAGTGGGTTTGTAGATGATTTTGATTCAAATCAAAATTTAACCGAATTACATCGGCAACATTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7XY81

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7XY73

References