Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1111838..1112433 Replicon chromosome
Accession NZ_CP017260
Organism Formosa sp. Hel1_33_131

Toxin (Protein)


Gene name hicA Uniprot ID A0A1D7XXL3
Locus tag FORMB_RS04920 Protein ID WP_069676395.1
Coordinates 1111838..1112077 (+) Length 80 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1D7XXQ2
Locus tag FORMB_RS04925 Protein ID WP_069676396.1
Coordinates 1112080..1112433 (+) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORMB_RS04895 1107354..1107833 + 480 WP_069676391.1 hypothetical protein -
FORMB_RS04900 1107977..1109452 - 1476 WP_069676392.1 Fic family protein -
FORMB_RS04905 1109680..1109967 - 288 WP_069676393.1 helix-turn-helix transcriptional regulator -
FORMB_RS04910 1110108..1110587 + 480 WP_069676394.1 hypothetical protein -
FORMB_RS04915 1110728..1111528 + 801 WP_083243910.1 Fic family protein -
FORMB_RS04920 1111838..1112077 + 240 WP_069676395.1 type II toxin-antitoxin system HicA family toxin Toxin
FORMB_RS04925 1112080..1112433 + 354 WP_069676396.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FORMB_RS04930 1112740..1112988 + 249 WP_069676397.1 hypothetical protein -
FORMB_RS04935 1112988..1113269 + 282 WP_069676398.1 plasmid stabilization protein -
FORMB_RS04940 1113643..1113882 + 240 WP_069676399.1 hypothetical protein -
FORMB_RS04945 1113889..1114170 + 282 WP_069676400.1 type II toxin-antitoxin system YafQ family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-78)

Antitoxin

Uncharacterised protein family HicB

(55-104)


Sequences

Toxin        


Download         Length: 80 a.a.        Molecular weight: 9346.18 Da        Isoelectric Point: 10.5505

>T66356 WP_069676395.1 NZ_CP017260:1111838-1112077 [Formosa sp. Hel1_33_131]
MSKTEKLLEKFKSIPNDLTWDELVKILNYLGYFELSKKGKTGGSRRKFVNELKDVINLHKPHPTKIIKKYMIKQLLEKL

Download         Length: 240 bp

>T66356 NZ_CP017260:1111838-1112077 [Formosa sp. Hel1_33_131]
ATGAGTAAGACAGAAAAACTCTTAGAAAAATTTAAAAGTATTCCTAATGATTTAACGTGGGATGAACTCGTTAAAATATT
AAATTATTTGGGGTATTTTGAATTATCAAAAAAAGGTAAAACAGGGGGTTCTCGACGAAAATTTGTAAATGAACTAAAAG
ACGTTATAAATTTACATAAACCGCACCCTACTAAGATTATTAAAAAGTATATGATTAAGCAATTATTAGAAAAACTATAA

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 13494.25 Da        Isoelectric Point: 4.7970

>AT66356 WP_069676396.1 NZ_CP017260:1112080-1112433 [Formosa sp. Hel1_33_131]
MKNTLEYKGYLGTVEYSNEDNCLYGKIIGIDDLVNYEAQSVEELNTYFKEAVEDYLATCKEVNKEPNKTFKGVFNVRTSK
DNHRALSMIAEKNKMKLNEVINKAFDFFITNEDKVLG

Download         Length: 354 bp

>AT66356 NZ_CP017260:1112080-1112433 [Formosa sp. Hel1_33_131]
ATGAAAAACACATTAGAATATAAAGGCTATTTAGGAACTGTAGAATATAGTAACGAAGATAATTGTCTTTATGGAAAAAT
TATAGGAATAGATGATTTAGTTAATTATGAAGCTCAATCGGTTGAAGAATTAAACACCTATTTTAAGGAAGCTGTTGAAG
ATTATTTAGCGACTTGTAAAGAAGTAAACAAAGAACCAAATAAAACATTTAAAGGCGTCTTTAATGTTCGTACCTCTAAA
GATAATCATAGAGCCTTATCAATGATCGCAGAAAAAAATAAGATGAAATTAAATGAAGTTATAAATAAAGCATTTGATTT
CTTTATAACAAATGAAGATAAAGTATTAGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7XXL3

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7XXQ2

References