Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3481049..3481527 Replicon chromosome
Accession NZ_CP017251
Organism Escherichia coli strain NADC 5570/86-24/6564 isolate wild

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag BHW77_RS18420 Protein ID WP_001303876.1
Coordinates 3481240..3481527 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag BHW77_RS18415 Protein ID WP_000536233.1
Coordinates 3481049..3481240 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BHW77_RS18380 3476453..3477223 - 771 WP_000450992.1 DUF1627 domain-containing protein -
BHW77_RS18385 3477245..3477991 - 747 WP_000788751.1 ATP-binding protein -
BHW77_RS18390 3477998..3479089 - 1092 WP_001205823.1 hypothetical protein -
BHW77_RS30120 3479168..3479623 + 456 WP_000273724.1 hypothetical protein -
BHW77_RS18400 3479830..3480255 - 426 WP_000693855.1 Rha family transcriptional regulator -
BHW77_RS18405 3480239..3480511 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
BHW77_RS18410 3480620..3481021 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
BHW77_RS18415 3481049..3481240 + 192 WP_000536233.1 hypothetical protein Antitoxin
BHW77_RS18420 3481240..3481527 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BHW77_RS18425 3481805..3481960 + 156 WP_000379575.1 DUF1391 family protein -
BHW77_RS18430 3482102..3482491 + 390 WP_000394511.1 hypothetical protein -
BHW77_RS18435 3482678..3482863 - 186 WP_001133046.1 hypothetical protein -
BHW77_RS18445 3483437..3483625 + 189 WP_000413705.1 cell division inhibition protein DicB -
BHW77_RS18450 3483622..3483813 + 192 WP_001098307.1 DUF1482 family protein -
BHW77_RS18455 3483907..3486378 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T66342 WP_001303876.1 NZ_CP017251:3481240-3481527 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T66342 NZ_CP017251:3481240-3481527 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT66342 WP_000536233.1 NZ_CP017251:3481049-3481240 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT66342 NZ_CP017251:3481049-3481240 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References