Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3481037..3481515 Replicon chromosome
Accession NZ_CP017249
Organism Escherichia coli strain NADC 5570/86-24/6565 isolate mutant

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag BHW76_RS18420 Protein ID WP_001303876.1
Coordinates 3481228..3481515 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag BHW76_RS18415 Protein ID WP_000536233.1
Coordinates 3481037..3481228 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BHW76_RS18380 3476441..3477211 - 771 WP_000450992.1 DUF1627 domain-containing protein -
BHW76_RS18385 3477233..3477979 - 747 WP_000788751.1 ATP-binding protein -
BHW76_RS18390 3477986..3479077 - 1092 WP_001205823.1 hypothetical protein -
BHW76_RS30155 3479156..3479611 + 456 WP_000273724.1 hypothetical protein -
BHW76_RS18400 3479818..3480243 - 426 WP_000693855.1 Rha family transcriptional regulator -
BHW76_RS18405 3480227..3480499 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
BHW76_RS18410 3480608..3481009 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
BHW76_RS18415 3481037..3481228 + 192 WP_000536233.1 hypothetical protein Antitoxin
BHW76_RS18420 3481228..3481515 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BHW76_RS18425 3481793..3481948 + 156 WP_000379575.1 DUF1391 family protein -
BHW76_RS18430 3482090..3482479 + 390 WP_000394511.1 hypothetical protein -
BHW76_RS18435 3482666..3482851 - 186 WP_001133046.1 hypothetical protein -
BHW76_RS18445 3483425..3483613 + 189 WP_000413705.1 cell division inhibition protein DicB -
BHW76_RS18450 3483610..3483801 + 192 WP_001098307.1 DUF1482 family protein -
BHW76_RS18455 3483895..3486366 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T66310 WP_001303876.1 NZ_CP017249:3481228-3481515 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T66310 NZ_CP017249:3481228-3481515 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT66310 WP_000536233.1 NZ_CP017249:3481037-3481228 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT66310 NZ_CP017249:3481037-3481228 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References