Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbE-relB/ParE-YafN
Location 2847913..2848427 Replicon chromosome
Accession NZ_CP017239
Organism Burkholderia cenocepacia strain CR318

Toxin (Protein)


Gene name stbE Uniprot ID -
Locus tag BHQ31_RS29845 Protein ID WP_077178611.1
Coordinates 2847913..2848131 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag BHQ31_RS29850 Protein ID WP_078041774.1
Coordinates 2848179..2848427 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BHQ31_RS29825 2843634..2844332 - 699 WP_011548926.1 MgtC/SapB family protein -
BHQ31_RS29830 2844447..2845556 + 1110 WP_077178613.1 AGE family epimerase/isomerase -
BHQ31_RS29835 2845529..2847148 - 1620 WP_077178612.1 Tar ligand binding domain-containing protein -
BHQ31_RS29840 2847427..2847870 + 444 WP_006480333.1 PaaI family thioesterase -
BHQ31_RS29845 2847913..2848131 - 219 WP_077178611.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BHQ31_RS29850 2848179..2848427 - 249 WP_078041774.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BHQ31_RS29855 2848556..2849608 - 1053 WP_078041775.1 CoA transferase -
BHQ31_RS29860 2849732..2850496 - 765 WP_023477581.1 helix-turn-helix domain-containing protein -
BHQ31_RS29865 2850631..2851413 + 783 WP_078041776.1 crotonase/enoyl-CoA hydratase family protein -
BHQ31_RS29870 2851486..2852706 + 1221 WP_078041777.1 CoA transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-63)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8407.88 Da        Isoelectric Point: 11.0031

>T66284 WP_077178611.1 NZ_CP017239:c2848131-2847913 [Burkholderia cenocepacia]
VRDQFKARLAERLEHPRIPSAKLHGHPDRYKIKLRGVGYRLVYEVRDAEVIVLVVAVGRRERDAVYLAAMKR

Download         Length: 219 bp

>T66284 NZ_CP017239:c2848131-2847913 [Burkholderia cenocepacia]
GTGCGCGATCAATTCAAGGCCAGGCTCGCCGAGCGGCTCGAGCATCCTCGTATCCCGTCAGCCAAATTGCATGGCCACCC
GGATCGCTACAAGATCAAGCTGCGCGGTGTCGGTTATCGCCTCGTCTACGAAGTGCGCGACGCGGAAGTCATCGTGCTGG
TGGTCGCGGTGGGCCGCCGCGAGCGTGATGCGGTCTATCTGGCTGCGATGAAACGCTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9057.23 Da        Isoelectric Point: 4.7318

>AT66284 WP_078041774.1 NZ_CP017239:c2848427-2848179 [Burkholderia cenocepacia]
MPHTNLASVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMVERLEDTDDNAMADSRAREKIVKVNWN
DL

Download         Length: 249 bp

>AT66284 NZ_CP017239:c2848427-2848179 [Burkholderia cenocepacia]
ATGCCTCACACCAATCTGGCTAGCGTGACGGCTAGCGTCTCGGAGCTGAAGCGGAATCCGATGGGAACCGTTGCCGCGGG
CGAGGGTTTTCCGGTCGCCATCCTGAATCACAACGAACCCGCGTTCTACTGCATTCCAGCGAAGACGTGGGAGGCGATGG
TCGAACGCCTGGAAGACACCGACGACAATGCGATGGCCGATTCGCGCGCCAGGGAGAAGATCGTCAAGGTCAATTGGAAT
GACCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References